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Chemical NICOTINE

Chemical ID
NICOTINE
Ubiquitous
No
List of known dosages
Dosage Reference
LD50=3-230 (orl mus) Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006., Merck 11th Edition, Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD50=55 mg/kg (orl rat) Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.
LDlo=1 mg/kg (orl hmn)
LDlo=30-60 mg/man Martindale's 28th
LD50=5 mg/kg (ivn dog)
LD50=7.1 mg/kg (ivn mus)
LD50=33.5 mg/kg (scu rat)
LD50=9.4 mg/kg (ivn rbt)
LD=6-9 mg/kg (ims cat) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=2 mg/kg (ivn cat) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=1 mg/kg (scu cat) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=9 mg/kg (ims cow) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=15 mg/kg (ims dog) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=15 mg/kg (ims gpg) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=30 mg/kg (ipr gpg) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=4.5 mg/kg (ivn gpg) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=80 mg/kg (scu gpg) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=8.8 mg/kg (ims horse) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=6 mg/kg (ims mky) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=8 mg/kg (ims mus) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=10 mg/kg (ipr mus) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=0.5 mg/kg (ivn mus) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=30 mg/kg (scu mus) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=14 mg/kg (ims pig) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=15 mg/kg (ims rat) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=20 mg/kg (ipr rat) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=3 mg/kg (ivn rat) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=190 mg/kg (orl rat)
LD=40 mg/kg (scu rat) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=30 mg/kg (ims rbt) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=14 mg/kg (ipr rbt) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=7 mg/kg (ivn rbt) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=200 mg/kg (orl rbt) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD=30 mg/kg (scu rbt) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Dosage Reference
Addictive not available Duke, 1992 *
Analgesic 2 mg/kg ipr mus Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.
Anorectic not available Duke, 1992 *
ANS-Paralytic not available Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
ANS-Stimulant not available Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Antiestrogenic not available Economic & Medicinal Plant Research, 6: 189.
Antifeedant not available Duke, 1992 *
Antifumitory not available Economic & Medicinal Plant Research, 6: 189.
Cardiovascular 0.25 mg/kg ivn dog Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.
Cholinergic not available Duke, 1992 *
Dopaminigenic not available Duke, 1992 *
Ectoparasiticide not available Merck 11th Edition
Epinephrininergic not available Duke, 1992 *
Herbicide IC57=5 mM Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.
Hyperglycemic not available Duke, 1992 *
Insecticide IC100=1,000 ppm Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.
Nematistat not available Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.
Neurotoxic not available R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R.
Pesticide not available Duke, 1992 *
Serotoninergic not available Duke, 1992 *
List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name Plant Part Low Parts Per Million High Parts Per Million Standard Deviation Reference
Apium graveolens Plant not available not available not available Pakistan Encyclopedia Planta Medica. 1986.
Asclepias syriaca Sprout Seedling not available not available not available Duke, 1992 *
Atropa bella-donna Leaf not available not available not available Duke, 1992 *
Bacopa monnieri Plant not available not available not available Wealth of India.
Carica papaya Leaf not available 102.8 -0.7 Jim Duke's personal files.
Carica papaya Plant not available not available not available List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Datura stramonium Plant not available not available not available Duke, 1992 *
Duboisia myoporoides Root not available not available not available Duke, 1992 *
Duboisia myoporoides Leaf not available 1700.0 -0.7 Duke, 1992 *
Duboisia myoporoides Stem not available not available not available Duke, 1992 *
Duboisia myoporoides Sprout Seedling not available not available not available Duke, 1992 *
Equisetum arvense Shoot not available not available not available Jim Duke's personal files.
Equisetum arvense Plant not available 0.4 not available Duke, 1992 *
Erythroxylum coca Leaf not available not available not available Duke, 1992 *
Huperzia spp Plant not available not available not available Duke, 1992 *
Juglans regia Leaf not available not available not available List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Lycopodium clavatum Pollen Or Spore not available not available not available Chemical Constituents of Oriental Herbs (3 diff. books)
Lycopodium lucidulum Plant not available not available not available Duke, 1992 *
Mucuna pruriens Seed not available not available not available Duke, 1992 *
Nicotiana glauca Leaf not available not available not available Duke, 1992 *