Chemical CAFFEINE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

CAFFEINE

CAS Registry Number

58082

Ubiquitous

List of known dosages
Dosage	Reference
LD50=127-1,200 (orl mus)	Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006., Merck 11th Edition
LD50=192 (orl rat)
LD50=200 (orl rat)
LD50=224-246 (orl rbt)
LD50=247-355 (orl rat)	Merck 11th Edition
LDlo=192 (orl hmn)

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
Topoisomerase-II-Inhibitor	99 mM	Shin, C. G., Strayer, J. M., Wani, M., Snapka, R. M. 1990. Rapid Evaluation of Topoisomerase Inhibitors: Caffeine Inhibition of Topoisomerases in vivo. Teratogen Carcinogen Mutagen, 10: 41-52.
Vasodilator	not available	Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp.

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Annona cherimola	Seed	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Seed	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Pericarp	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Anther	0.1	not available	not available	Duke, 1992 *
Camellia sinensis	Leaf	3810.0	93000.0	1.4	Duke, 1992 *
Camellia sinensis	Tissue Culture	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Shoot	38100.0	47900.0	not available	Duke, 1992 *
Camellia sinensis	Seed Coat	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Flower	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Plant	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Stem	not available	not available	not available	Duke, 1992 *
Citrus limon	Flower	not available	50.0	0.2	Duke, 1992 *
Citrus paradisi	Flower	not available	29.0	-1.3	CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses
Citrus sinensis	Bud	not available	0.3	not available	Jim Duke's personal files.
Citrus sinensis	Flower	not available	62.0	1.1	Jim Duke's personal files.
Citrus sinensis	Leaf	not available	6.0	-0.9	Jim Duke's personal files.
Coffea arabica	Seed	600.0	32000.0	0.3	Duke, 1992 *
Cola acuminata	Seed	10000.0	25000.0	0.0	Duke, 1992 *
Firmiana simplex	Seed	not available	not available	not available	Duke, 1992 *
Genipa americana	Seed	not available	22500.0	-0.1	Grenand, P., Moretti, C., and Jacquemin, H. 1987. Pharmacopees Traditionnelles en Guyane. l'ORSTROM, Paris. 569 pp.