Chemical CAFFEINE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

CAFFEINE

CAS Registry Number

58082

Ubiquitous

List of known dosages
Dosage	Reference
LD50=127-1,200 (orl mus)	Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006., Merck 11th Edition
LD50=192 (orl rat)
LD50=200 (orl rat)
LD50=224-246 (orl rbt)
LD50=247-355 (orl rat)	Merck 11th Edition
LDlo=192 (orl hmn)

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
FLavor	FEMA 125	Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry
Herbicide	not available	Duke, 1992 *
Hypertensive	not available	Duke, 1992 *
Hypoglycemic	not available	Duke, 1992 *
Insecticide	not available	Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.
Lypolytic	not available	Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp.
Myorelaxant	not available	McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82.
Neurotoxic	not available	R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R.
Pesticide	not available	Duke, 1992 *
Phosphodiesterase-Inhibitor	not available	Duke, 1992 *
Pyrogenic	60 mg/day oral hmn	Daroca, P., Rodriguez, J., Reano, M., Canto, G., Miranda, P. 1996. Fever From Caffeine. Allergy, 51(3): 189-191.
Pyrogenic	13.3 mg/kg ipr rbt	Dascombe, M. J. 1977. Effects of Methylxanthine Drugs on Pyrogen-Induced Hyperthermia. Eur J Pharmacol, 45: 389-392.
Pyrogenic	15 mg/kg ipr cat	Dascombe, M. J. 1977. Effects of Methylxanthine Drugs on Pyrogen-Induced Hyperthermia. Eur J Pharmacol, 45: 389-392.
Respirastimulant	not available	Duke, 1992 *
Spasmogenic	1,500 mg/man	Duke, 1992 *
Stimulant	not available	R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R.
Tachycardic	1,500 mg/man	Duke, 1992 *
Teratogenic	14 orl rat	Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.
Topoisomerase-I-Inhibitor	0.1 nM	Tohda, H., Zhao, J. H., Oikawa, A. 1992. A Possible Involvement of DNA Topoisomerase I in 'Caffeine Effect' After Ultraviolet Irradiation. Tohoku J Exp Med, 168: 129-132.
Topoisomerase-I-Inhibitor	75 uM	Shin, C. G., Strayer, J. M., Wani, M., Snapka, R. M. 1990. Rapid Evaluation of Topoisomerase Inhibitors: Caffeine Inhibition of Topoisomerases in vivo. Teratogen Carcinogen Mutagen, 10: 41-52.

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Annona cherimola	Seed	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Flower	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Plant	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Stem	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Seed	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Pericarp	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Anther	0.1	not available	not available	Duke, 1992 *
Camellia sinensis	Tissue Culture	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Leaf	3810.0	93000.0	1.4	Duke, 1992 *
Camellia sinensis	Seed Coat	not available	not available	not available	Duke, 1992 *
Camellia sinensis	Shoot	38100.0	47900.0	not available	Duke, 1992 *
Citrus limon	Flower	not available	50.0	0.2	Duke, 1992 *
Citrus paradisi	Flower	not available	29.0	-1.3	CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses
Citrus sinensis	Bud	not available	0.3	not available	Jim Duke's personal files.
Citrus sinensis	Flower	not available	62.0	1.1	Jim Duke's personal files.
Citrus sinensis	Leaf	not available	6.0	-0.9	Jim Duke's personal files.
Coffea arabica	Seed	600.0	32000.0	0.3	Duke, 1992 *
Cola acuminata	Seed	10000.0	25000.0	0.0	Duke, 1992 *
Firmiana simplex	Seed	not available	not available	not available	Duke, 1992 *
Genipa americana	Seed	not available	22500.0	-0.1	Grenand, P., Moretti, C., and Jacquemin, H. 1987. Pharmacopees Traditionnelles en Guyane. l'ORSTROM, Paris. 569 pp.