Biological Activity COX-1-Inhibitor

List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)

Chemical Name Sort descending	Dosage	Reference
(+)-CATECHIN	IC50=183-279 uM (cf indomethacin IC50=1 uM)	Duke, 1992 *
(-)-EPIAFZELECHIN	IC50=15 uM/	Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER	IC16=100 ug/ml	Duke, 1992 *
AIPHANOL	not available	Duke, 1992 *
ANTHOCYANINS	IC45=125 ug/ml	Duke, 1992 *
APIGENIN	IC65=1,000 uM	Duke, 1992 *
BAICALEIN	100 ug/ml	Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE	IC78=50 ug/ml	Duke, 1992 *
CATECHIN	IC50=80 uM (cf indomethacin IC50=1 uM)	Duke, 1992 *
CINNAMIC-ACID-BORNYL-ESTER	IC66=100 ug/ml	Duke, 1992 *
CIRSILINEOL	IC37=1,000 uM	Duke, 1992 *
CIRSIMARITIN	IC50=1,000 uM	Duke, 1992 *
CYANIDIN-3-O-GLUCOSIDE	IC30=100 ug/ml	Duke, 1992 *
DIRCA-PHENOLIC-GLUCOSIDE-5	125 ug/ml	Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL	IC97=1,000 uM	Duke, 1992 *
FLAVOKAWAIN-B	IC77=100 ug/ml	Duke, 1992 *
FLAVOKAWAIN-B	IC55=12.5 ug/ml	Duke, 1992 *
ISOTHYMONIN	IC37=1,000 uM	Duke, 1992 *
LAURIC-ACID	IC40=100	Duke, 1992 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE	IC50=0.5 uM/	Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.