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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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COX-1-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml *
AIPHANOL *
ANTHOCYANINS IC45=125 ug/ml *
APIGENIN IC65=1,000 uM *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml *
CIRSILINEOL IC37=1,000 uM *
CIRSIMARITIN IC50=1,000 uM *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM *
FLAVOKAWAIN-B IC77=100 ug/ml *
FLAVOKAWAIN-B IC55=12.5 ug/ml *
ISOTHYMONIN IC37=1,000 uM *
LAURIC-ACID IC40=100 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=0.5 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Abrus precatorius Crab's Eye; Jequerity; Coral Beadplant; Indian Licorice; Licorice Vine; Love Bean; Lucky Bean; Minnie-Minnies; Prayer Beads; Precatory Bean; Red Beadvine; Rosary Pea; Weatherplant; Weathervine; Jequirity Bean 1 0
Abutilon theophrasti Velvet Leaf; Butterprint; Indian-Mallow; Abutilon-Hemp 1 0
Acacia decurrens Green Wattle 2 0
Acacia farnesiana Cassie; Huisache; Sweet Acacia; Opopanax; Popinac 2 3, 230
Acacia nilotica Babul 2 0
Achillea millefolium Yarrow; Milfoil 3 0
Acinos suaveolens 1 23.299999237060547
Acorus calamus Sweetflag; Calamus; Flagroot; Myrtle Flag; Sweet Calamus; Sweetroot 1 1, 800
Actaea racemosa Black Cohosh; Black Snakeroot 1 4.800000190734863
Actinidia chinensis Kiwi 1 6
Aegle marmelos Bael de India; Bael fruit 1 2.5999999046325684
Aesculus hippocastanum Horse Chestnut 2 0
Agastache rugosa 2 9, 000
Agathosma betulina Buchu; Honey Buchu; Mountain Buchu 1 0
Ageratum conyzoides Mexican ageratum 1 800
Aglaonema commutatum Aglaonema aroid 1 0
Agrimonia eupatoria Agrimony; Sticklewort 2 52, 000
Aleurites moluccana Candlenut; Candleberry; Candlenut Tree; Indian Walnut; Lumbangtree; Varnishtree 1 0
Allium ampeloprasum Elephant Garlic; Kurrat 1 765.5999999046326
Allium cepa Onion; Shallot 2 476