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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
HYPEROSIDE Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
INDOLE *
IRIDINE IC21=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
ISOCHLOROGENIC-ACID-A 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
ISOCHLOROGENIC-ACID-B 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
ISOFRAXIDIN 10 ug/ml cow (weak activity, 18% inhibition) Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
ISOLIQUIRITIGENIN IC50=0.32 uM *
ISOLIQUIRITIGENIN 0.1 ug/ml *
ISOLIQUIRITIN IC50=0.72 uM Aida, K., Tawata, M., Shindo, H., Onaya, T., Sasaki, H., Yamaguchi, T., Chin, M.(Chen, Z.), and Mitsuhashi, H. 1989. Isoliquiritigenin: A New Aldose Reductase Inhibitor from Glycyrrhizae Radix. Planta Medica 56(3): 254-258.
ISOQUERCITRIN Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
ISOSCOPOLETIN 10 ug/ml cow (weak activity) Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
JIOCAROTENOSIDE-A-1 Sasaki, H., Nishimura, H., Morota, T., Katshara, T., Zhengxiong, C., Mitsuhashi, H. 1991. Norcarotenoid Glycosides of Rehmannia glutinosa var. purpurea. Phytochemistry, 30(5): 1639-1644.
JIONOSIDE IC50=0.51uM *
JUGLANIN IC65=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KAEMPFEROL 100 uM Oliveira, T. T., Nagem, T. J., Miranda, L. C. G., Paula, V. F., Teixeira, M. A. 1997. Inhibitory Action on Aldose Reductase by Soybean Flavonoids. J Braz Chem Soc, 8(3): 211-213.
KAEMPFEROL-3-RHAMNOSIDE IC85=10 uM *
KAEMPFEROL-3-RHAMNOSIDE IC43=1uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KAEMPFEROL=3=NEOHESPERIDOSIDE IC30=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KOLAVIRON IC50= 5.4 Iwu, M. M., Igboko, O. A., Okunji, C. O., and Tempesta, M. S., Antidiabetic and aldose reductase activities in biflavanones of Garcinia kola, J. Pharm Pharmacol, 42(4), 1990, 290-2.
KOLAVIRON IC50=5.4 Iwu, M. M., Igboko, O. A., Okunji, C. O., and Tempesta, M. S., Antidiabetic and aldose reductase activities in biflavanones of Garcinia kola, J. Pharm Pharmacol, 42(4), 1990, 290-2.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Manilkara zapota Sapodilla 1 625
Maranta arundinacea Arrowroot; Bermuda Arrowroot 4 430
Marrubium vulgare Horehound; White Horehound 11 0
Matricaria recutita Annual Camomile; German Camomile; Wild Camomile 18 3, 615
Mauritia flexuosa Aguaje; Buruti; Morichi palm 1 0
Medicago sativa Alfalfa; Lucerne 12 3, 516
Melaleuca alternifolia Teatree 6 873, 861
Melaleuca bracteata Bracteate Tea-Tree 1 100
Melaleuca cajuputi Vietnamese Cajuput Oil 1 730
Melaleuca leucadendra Cajeput 4 0
Melaleuca linariifolia Paperbark Tea_tree 3 200
Melaleuca viridiflora Broad-Leaf Tea-Tree; Niaouli 2 0
Melia azedarach Chinaberry 11 0
Melicoccus bijugatas Genip; Honey berry; Mamoncillo; Pitomba 1 920
Melilotus officinalis Yellow Sweetclover 7 7, 412.5
Melissa officinalis Balm; Lemonbalm; Melissa; Bee Balm 12 273, 045.20000076294
Mentha aquatica Water Mint 6 27, 031.10000000149
Mentha arvensis var. piperascens Cornmint; Field Mint; Japanese Mint 5 94, 839
Mentha longifolia Biblical Mint 10 41, 087
Mentha pulegium European Pennyroyal 7 69, 870