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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
HYPEROSIDE Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
INDOLE *
IRIDINE IC21=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
ISOCHLOROGENIC-ACID-A 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
ISOCHLOROGENIC-ACID-B 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
ISOFRAXIDIN 10 ug/ml cow (weak activity, 18% inhibition) Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
ISOLIQUIRITIGENIN IC50=0.32 uM *
ISOLIQUIRITIGENIN 0.1 ug/ml *
ISOLIQUIRITIN IC50=0.72 uM Aida, K., Tawata, M., Shindo, H., Onaya, T., Sasaki, H., Yamaguchi, T., Chin, M.(Chen, Z.), and Mitsuhashi, H. 1989. Isoliquiritigenin: A New Aldose Reductase Inhibitor from Glycyrrhizae Radix. Planta Medica 56(3): 254-258.
ISOQUERCITRIN Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
ISOSCOPOLETIN 10 ug/ml cow (weak activity) Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
JIOCAROTENOSIDE-A-1 Sasaki, H., Nishimura, H., Morota, T., Katshara, T., Zhengxiong, C., Mitsuhashi, H. 1991. Norcarotenoid Glycosides of Rehmannia glutinosa var. purpurea. Phytochemistry, 30(5): 1639-1644.
JIONOSIDE IC50=0.51uM *
JUGLANIN IC65=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KAEMPFEROL 100 uM Oliveira, T. T., Nagem, T. J., Miranda, L. C. G., Paula, V. F., Teixeira, M. A. 1997. Inhibitory Action on Aldose Reductase by Soybean Flavonoids. J Braz Chem Soc, 8(3): 211-213.
KAEMPFEROL-3-RHAMNOSIDE IC43=1uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KAEMPFEROL-3-RHAMNOSIDE IC85=10 uM *
KAEMPFEROL=3=NEOHESPERIDOSIDE IC30=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KOLAVIRON IC50= 5.4 Iwu, M. M., Igboko, O. A., Okunji, C. O., and Tempesta, M. S., Antidiabetic and aldose reductase activities in biflavanones of Garcinia kola, J. Pharm Pharmacol, 42(4), 1990, 290-2.
KOLAVIRON IC50=5.4 Iwu, M. M., Igboko, O. A., Okunji, C. O., and Tempesta, M. S., Antidiabetic and aldose reductase activities in biflavanones of Garcinia kola, J. Pharm Pharmacol, 42(4), 1990, 290-2.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Gliricidia sepium Mata Raton 1 3, 145
Gloriosa superba Glory Lily 1 0
Glycine max Soybean 18 270, 400
Glycine wightii 1 4.989999771118164
Glycyrrhiza glabra Commom Licorice; Licorice; Smooth Licorice; Licorice-Root 18 107, 808
Glycyrrhiza uralensis Chinese Licorice; Gan-Cao; Kan-Tsao 10 208, 740
Gossypium sp Cotton 11 84, 640
Guazuma tomentosa 2 0
Gymnema sylvestre Gymnema; Miracle Fruit 2 1, 600
Haematoxylum campechianum Campechy; Logwood 2 240, 000
Hamamelis virginiana Witch Hazel 6 0
Hardenbergia violacea 1 8
Harpagophytum procumbens Devil's Claw; Grapple Plant 9 0
Hedeoma drummondii Drummond's Pennyroyal 1 232
Hedeoma hispida Hispid Pennyroyal 2 638
Hedeoma pulegioides American Pennyroyal 3 300
Hedeoma reverchonii Reverchon's Pennyroyal 2 970
Hedera helix Ivy 4 0
Hedychium flavum Yellow Ginger Lily 1 10
Heimia salicifolia Sinicuichi 1 0