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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
NEOASTILBIN 60 uM pig Haraguchi, H., Ohmi, I., Masuda, H., Tamura, Y., Mizutani, K., Tanaka, O., Chou, W. H. 1996. Inhibition of Aldose Reductase by Dihydroflavonols in Engelhardtia chrysolepis and Effects on Other Enzymes. Experientia, 52(6): 564-567.
NEPETIN ED50=1 uM *
NEPETRIN ED50=1-10 uM *
NEROLIDOL *
NEVADENSIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
ORAPOSIDE IC50=0.15 uM Andary, C. Caffeic Acid Glycoside Esters and Pharmacology. Polyphenolic Phenom, 1993: 237-245.
OROXYLIN-A IC50=52 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
OXYAYANIN-A IC27=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
P-COUMARIC-ACID 4 ug/ml (weak activity) Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
PECTOLINARIGENIN IC25=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
PECTOLINARIN IC42=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
PENTABROMOPROPEN-2-YL-DIBROMO-ACETATE 4 ug/ml Sugano, M., Sato, A., Nagaki, H., Yoshioka, S., Shiraki, T., Horikoshi, H. 1990. Aldose Reductase Inhibitors from the Red Alga, Asparagopsis taxiformis. Tetrahedron Lett, 31(48): 7015-7016.
PENTABROMOPROPEN-2-YL-TRIBROMO-ACETATE 4 ug/ml Sugano, M., Sato, A., Nagaki, H., Yoshioka, S., Shiraki, T., Horikoshi, H. 1990. Aldose Reductase Inhibitors from the Red Alga, Asparagopsis taxiformis. Tetrahedron Lett, 31(48): 7015-7016.
PERILLOSIDE-A 0.1 mM/l rat Fujita, T., Ohira, K., Miyatake, K., Nakano, Y., Nakayama, M. 1995. Inhibitory Effect of Perillosides A and C, Related Monoterpene Glucosides on Aldose Reductase and Their Structure-Activity Relationships. Chem Pharm Bull, 43(6): 920-926.
PERILLOSIDE-A 0.1 mM/l hmn (weak activity) Fujita, T., Ohira, K., Miyatake, K., Nakano, Y., Nakayama, M. 1995. Inhibitory Effect of Perillosides A and C, Related Monoterpene Glucosides on Aldose Reductase and Their Structure-Activity Relationships. Chem Pharm Bull, 43(6): 920-926.
PERILLOSIDE-B 0.1 mM/l rat Fujita, T., Ohira, K., Miyatake, K., Nakano, Y., Nakayama, M. 1995. Inhibitory Effect of Perillosides A and C, Related Monoterpene Glucosides on Aldose Reductase and Their Structure-Activity Relationships. Chem Pharm Bull, 43(6): 920-926.
PERILLOSIDE-C 0.1 mM/l hmn (weak activity) Fujita, T., Ohira, K., Miyatake, K., Nakano, Y., Nakayama, M. 1995. Inhibitory Effect of Perillosides A and C, Related Monoterpene Glucosides on Aldose Reductase and Their Structure-Activity Relationships. Chem Pharm Bull, 43(6): 920-926.
PERILLOSIDE-C 0.1 mM/l rat Fujita, T., Ohira, K., Miyatake, K., Nakano, Y., Nakayama, M. 1995. Inhibitory Effect of Perillosides A and C, Related Monoterpene Glucosides on Aldose Reductase and Their Structure-Activity Relationships. Chem Pharm Bull, 43(6): 920-926.
PERILLOSIDE-D 0.1 mM/l rat Fujita, T., Ohira, K., Miyatake, K., Nakano, Y., Nakayama, M. 1995. Inhibitory Effect of Perillosides A and C, Related Monoterpene Glucosides on Aldose Reductase and Their Structure-Activity Relationships. Chem Pharm Bull, 43(6): 920-926.
PROTOPINE 50 uM Kubo, M., et al. 1994. Studies on Anti-cataract Drugs from Natural Sources. I. Effects of a Methanolic Extract and the Alkaloidal Components from Corydalis Tuber on in vit Aldose Reductase Activity. Biol Pharm Bull, 17(3): 458-459.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Gliricidia sepium Mata Raton 1 3, 145
Gloriosa superba Glory Lily 1 0
Glycine max Soybean 18 270, 400
Glycine wightii 1 4.989999771118164
Glycyrrhiza glabra Commom Licorice; Licorice; Smooth Licorice; Licorice-Root 18 107, 808
Glycyrrhiza uralensis Chinese Licorice; Gan-Cao; Kan-Tsao 10 208, 740
Gossypium sp Cotton 11 84, 640
Guazuma tomentosa 2 0
Gymnema sylvestre Gymnema; Miracle Fruit 2 1, 600
Haematoxylum campechianum Campechy; Logwood 2 240, 000
Hamamelis virginiana Witch Hazel 6 0
Hardenbergia violacea 1 8
Harpagophytum procumbens Devil's Claw; Grapple Plant 9 0
Hedeoma drummondii Drummond's Pennyroyal 1 232
Hedeoma hispida Hispid Pennyroyal 2 638
Hedeoma pulegioides American Pennyroyal 3 300
Hedeoma reverchonii Reverchon's Pennyroyal 2 970
Hedera helix Ivy 4 0
Hedychium flavum Yellow Ginger Lily 1 10
Heimia salicifolia Sinicuichi 1 0