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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
3,3',4-TRI-O-METHYL-ELLAGIC-ACID IC50=0.08 uM Terashima, S., Shimizu, M., Nakayama, H., Ishikura, M., et al. 1990. Studies on Aldose Reductase Inhibitors from Medicinal Plant of 'Sinfito,' Potentilla candicans, and Further Synthesis of Their Related Compounds. Chem. Pharm. Bull 38(10):2733-2736, 1990
3,4-DIMETHOXYCINNAMIC-ACID 4 ug/ml (weak activity) Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
3-(PENTADECA-CIS-8-CIS-11,14-TRIENYL)-PHENOL IC50=180.9 uM Toyomizu, M., Sugiyama, S., Jin, R. L., Nakatsu, T. 1993. Alpha-Glucosidase and Aldose Reductase Inhibitors: Constituents of Cashew, Anacardium occidentale, Nut Shell Liquids. Phytotherapy Research, 7(3): 252-254.
3-(PENTADECA-CIS-8-CIS-12-DIENYL)-PHENOL IC50=332.8 uM Toyomizu, M., Sugiyama, S., Jin, R. L., Nakatsu, T. 1993. Alpha-Glucosidase and Aldose Reductase Inhibitors: Constituents of Cashew, Anacardium occidentale, Nut Shell Liquids. Phytotherapy Research, 7(3): 252-254.
3-ACETYL-3',4'-DIHYDROXY-5,6,7-TRIMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
3-HYDROXY-6-METHOXY-COUMARIN 10 uM (weak activity) Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
3-HYDROXY-COUMARIN 10 uM (weak activity) Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4',5,6,7-TETRAHYDROXY-3',8-DIMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4',5,7-TRIHYDROXY-6,8-DIMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4',6-DIHYDROXY-3',5,7,8-TETRAMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4',6-DIHYDROXY-5,7,8-TRIMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4'-HYDROXY-3',5,6,7,8-PENTAMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4'-HYDROXY-5,6,7,8-TETRAMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4-(ALPHA-RHAMNOPYRANOSYL)ELLAGIC-ACID IC50=4.1 x 10(-8) M *
4-HYDROXY-6,7-METHYLENEDIOXY-COUMARIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
4-HYDROXYCOUMARIN IC50=0.53 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
4-METHOXYCOUMARIN 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
4-O-METHYLELLAGIC-ACID *
5,6,7-TRIHYDROXY-8-METHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
5,6-DIHYDROXY-7,8-DIMETHOXY-FLAVONE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Eriobotrya japonica Loquat 6 21, 840
Eriodictyon californicum Yerba Santa; California Yerba Santa; Hierba Santa; Mountain Balm; Bear's Weed; Consumptive's Weed; Tarweed; Gum Bush; Holy Herb 6 1, 730, 877.3000004292
Eriosema glomeratum 1 6
Eriosema nutans 1 7
Eriosema psoraleoides 1 6
Eruca sativa Achnef (Berber; BOU); Garden Rocket (Eng.; USN); Rocket Salad (Eng.; USN); Rugula (Eng.; USN); Salad Rocket (Eng.; USN); Roquette (Eng.; Fr.; BOU); Olrauke (Ger.; USN); Ruke (Ger.; USN); Senfrauke (Ger.; USN); Jamba (India); Taramira (India; Nwp.); Rucola (It.; Malta; Sp.); Rabano silvestre (It.; Port.;); Oruga comun (Sp.; USN); Roqueta (Sp.; USN); Ackerrauke (Ger.; MAD); Ai'afein (Arab.; BOU); Ai'sha (Arab.; BOU); Aruca (Malta; KAB); Arugula (Eng.; FAC; USN); Assu (Punjab; SKJ); Baglet (Arab.; BOU); Bhutaghna (Sansk.; SKJ); Bimbata (Sansk.; KAB); Bou kahli (Arab.; BOU); Chara (Kumaon; DEP); Daradharsha (Sansk.; KAB); Djerdjir (Arab.; BOU); Dua (Kumaon; DEP); Duan (Nwp; KAB); Eihukan (Iran; NAD); Eruca (Malta; KAB); Euzomon (Greece; EB54:155); Gargir (Arab.; Hebrew; BOU); Gery (Arab.; BOU); Grahagna (Sansk.; KAB); Horf (Arab.; BOU); Izgin (Turkey; EB54:155); Jambeh (Iran; DEP; KAB); Jambeho (Sind.; KAB); Jambho (Sind.; DEP); Jamnia (Punjab; DEP); Kadamba (Sansk.; KAB); Kadambaka (Sansk.; KAB); Kerkas (Arab.; BOU); Kibana suzushiro (Jap.; TAN); Lalu (Nwp.; KAB); Lamba (India; USN); Mandao (Afg.; DEP; KAB); Mulai (Loralai; KAB); Oroth (Bible; EB52:394); Piao erh ts'ai (Chi.; TAN); Rajakshavaka (Sansk.; KAB); Rajika (Sansk.; KAB); Rakshitaphala (Sansk.; KAB); Rawk (Arab.; BOU); Rocket (Eng.; BOU); Roquette cultivee (Fr.; KAB); Roquette des jardins (Fr.;KAB); Roquette vraie (Fr.; BOU); Rouka (Arab.; BOU); Ruca (Catalan; KAB); Rucheta (Malta; KAB); Sahwan (Nwp.; KAB); Sarishapa (Sansk.; KAB); Sarshapa (Sansk.; KAB); Sfed sarson (Hindi; MPI); Shiltam (Arab.; BOU); Shwetsursha (Bengal; SKJ); Siddartha (Sansk.; DEP; SKJ); Sidhaprayojana (Sansk.; KAB); Sidharta (Sansk.; KAB); Suffed shorshi (Bengal; DEP); Tanakfail (Berber; BOU); Tantubha (Sansk.; KAB); Tantuka (Sansk.; KAB); Tara (Nwp.; Punjab; KAB; SKJ); Thorfel (Berber; BOU); Tira (Nwp.; DEP; KAB); Tuverika (Sansk.; KAB); Ugragandha (Sansk.; KAB) 1 0
Eryngium floridanum Florida Eryngium 1 1, 958
Erythrina berteroana Pito 1 2, 340
Erythrina crista-galli Cockspur Coral Tree 1 0
Erythrina fusca Coral Bean; Gallito 1 1, 560
Erythrina sp 1 0
Erythroxylum coca Coca 8 10, 115
Erythroxylum novogranatense Coca 2 10, 100
Eschscholzia californica California Poppy 4 100, 560
Eucalyptus albens 4 18.30000000447035
Eucalyptus angulosa 4 72.5
Eucalyptus astringens 4 310.30000000447035
Eucalyptus behriana 4 10.800000190734863
Eucalyptus blakelyi 4 2, 585.3000000044703
Eucalyptus bosistoana 4 204.20000000298023