An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
  1. Home
  2. Aldose-Reductase-Inhibitor

Aldose-Reductase-Inhibitor

Download these results as:
CSV
EXCEL
PDF
List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
HYPEROSIDE Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
INDOLE *
IRIDINE IC21=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
ISOCHLOROGENIC-ACID-A 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
ISOCHLOROGENIC-ACID-B 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
ISOFRAXIDIN 10 ug/ml cow (weak activity, 18% inhibition) Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
ISOLIQUIRITIGENIN IC50=0.32 uM *
ISOLIQUIRITIGENIN 0.1 ug/ml *
ISOLIQUIRITIN IC50=0.72 uM Aida, K., Tawata, M., Shindo, H., Onaya, T., Sasaki, H., Yamaguchi, T., Chin, M.(Chen, Z.), and Mitsuhashi, H. 1989. Isoliquiritigenin: A New Aldose Reductase Inhibitor from Glycyrrhizae Radix. Planta Medica 56(3): 254-258.
ISOQUERCITRIN Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
ISOSCOPOLETIN 10 ug/ml cow (weak activity) Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
JIOCAROTENOSIDE-A-1 Sasaki, H., Nishimura, H., Morota, T., Katshara, T., Zhengxiong, C., Mitsuhashi, H. 1991. Norcarotenoid Glycosides of Rehmannia glutinosa var. purpurea. Phytochemistry, 30(5): 1639-1644.
JIONOSIDE IC50=0.51uM *
JUGLANIN IC65=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KAEMPFEROL 100 uM Oliveira, T. T., Nagem, T. J., Miranda, L. C. G., Paula, V. F., Teixeira, M. A. 1997. Inhibitory Action on Aldose Reductase by Soybean Flavonoids. J Braz Chem Soc, 8(3): 211-213.
KAEMPFEROL-3-RHAMNOSIDE IC85=10 uM *
KAEMPFEROL-3-RHAMNOSIDE IC43=1uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KAEMPFEROL=3=NEOHESPERIDOSIDE IC30=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
KOLAVIRON IC50=5.4 Iwu, M. M., Igboko, O. A., Okunji, C. O., and Tempesta, M. S., Antidiabetic and aldose reductase activities in biflavanones of Garcinia kola, J. Pharm Pharmacol, 42(4), 1990, 290-2.
KOLAVIRON IC50= 5.4 Iwu, M. M., Igboko, O. A., Okunji, C. O., and Tempesta, M. S., Antidiabetic and aldose reductase activities in biflavanones of Garcinia kola, J. Pharm Pharmacol, 42(4), 1990, 290-2.
Download these results as:
CSV
EXCEL
PDF
List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Eriobotrya japonica Loquat 6 21, 840
Eriodictyon californicum Yerba Santa; California Yerba Santa; Hierba Santa; Mountain Balm; Bear's Weed; Consumptive's Weed; Tarweed; Gum Bush; Holy Herb 6 1, 730, 877.3000004292
Eriosema glomeratum 1 6
Eriosema nutans 1 7
Eriosema psoraleoides 1 6
Eruca sativa Achnef (Berber; BOU); Garden Rocket (Eng.; USN); Rocket Salad (Eng.; USN); Rugula (Eng.; USN); Salad Rocket (Eng.; USN); Roquette (Eng.; Fr.; BOU); Olrauke (Ger.; USN); Ruke (Ger.; USN); Senfrauke (Ger.; USN); Jamba (India); Taramira (India; Nwp.); Rucola (It.; Malta; Sp.); Rabano silvestre (It.; Port.;); Oruga comun (Sp.; USN); Roqueta (Sp.; USN); Ackerrauke (Ger.; MAD); Ai'afein (Arab.; BOU); Ai'sha (Arab.; BOU); Aruca (Malta; KAB); Arugula (Eng.; FAC; USN); Assu (Punjab; SKJ); Baglet (Arab.; BOU); Bhutaghna (Sansk.; SKJ); Bimbata (Sansk.; KAB); Bou kahli (Arab.; BOU); Chara (Kumaon; DEP); Daradharsha (Sansk.; KAB); Djerdjir (Arab.; BOU); Dua (Kumaon; DEP); Duan (Nwp; KAB); Eihukan (Iran; NAD); Eruca (Malta; KAB); Euzomon (Greece; EB54:155); Gargir (Arab.; Hebrew; BOU); Gery (Arab.; BOU); Grahagna (Sansk.; KAB); Horf (Arab.; BOU); Izgin (Turkey; EB54:155); Jambeh (Iran; DEP; KAB); Jambeho (Sind.; KAB); Jambho (Sind.; DEP); Jamnia (Punjab; DEP); Kadamba (Sansk.; KAB); Kadambaka (Sansk.; KAB); Kerkas (Arab.; BOU); Kibana suzushiro (Jap.; TAN); Lalu (Nwp.; KAB); Lamba (India; USN); Mandao (Afg.; DEP; KAB); Mulai (Loralai; KAB); Oroth (Bible; EB52:394); Piao erh ts'ai (Chi.; TAN); Rajakshavaka (Sansk.; KAB); Rajika (Sansk.; KAB); Rakshitaphala (Sansk.; KAB); Rawk (Arab.; BOU); Rocket (Eng.; BOU); Roquette cultivee (Fr.; KAB); Roquette des jardins (Fr.;KAB); Roquette vraie (Fr.; BOU); Rouka (Arab.; BOU); Ruca (Catalan; KAB); Rucheta (Malta; KAB); Sahwan (Nwp.; KAB); Sarishapa (Sansk.; KAB); Sarshapa (Sansk.; KAB); Sfed sarson (Hindi; MPI); Shiltam (Arab.; BOU); Shwetsursha (Bengal; SKJ); Siddartha (Sansk.; DEP; SKJ); Sidhaprayojana (Sansk.; KAB); Sidharta (Sansk.; KAB); Suffed shorshi (Bengal; DEP); Tanakfail (Berber; BOU); Tantubha (Sansk.; KAB); Tantuka (Sansk.; KAB); Tara (Nwp.; Punjab; KAB; SKJ); Thorfel (Berber; BOU); Tira (Nwp.; DEP; KAB); Tuverika (Sansk.; KAB); Ugragandha (Sansk.; KAB) 1 0
Eryngium floridanum Florida Eryngium 1 1, 958
Erythrina berteroana Pito 1 2, 340
Erythrina crista-galli Cockspur Coral Tree 1 0
Erythrina fusca Coral Bean; Gallito 1 1, 560
Erythrina sp 1 0
Erythroxylum coca Coca 8 10, 115
Erythroxylum novogranatense Coca 2 10, 100
Eschscholzia californica California Poppy 4 100, 560
Eucalyptus albens 4 18.30000000447035
Eucalyptus angulosa 4 72.5
Eucalyptus astringens 4 310.30000000447035
Eucalyptus behriana 4 10.800000190734863
Eucalyptus blakelyi 4 2, 585.3000000044703
Eucalyptus bosistoana 4 204.20000000298023