Lepechinia hastata | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Activities: 20

Chemicals w/Activities: 2

All Chemicals: 2

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# Activity	Chemical Name	Part	Low PPM	High PPM	StdDev	^*Reference
2	CARNOSIC-ACID	Shoot	--	6500.0	2.69	Bruno, M., Savona, G., Piozzi, F., De la Torre, M. C., Rodriguez, B., Marlier, M. 1991. Abietane Diterpenoids from Lepechinia meyeni and Lepechinia hastata. Phytochemistry, 30(7): 2339-2343.
Antimutagenic Economic & Medicinal Plant Research, 6: 235. Antioxidant IC50=0.81 uM *
20	CARNOSOL	Shoot	--	4190.0	1.74	Encarnacion-Dimayuga, R., Almada, G., Virgen, M. 1998. Minimum Antimicrobial Inhibitory Concentration of Carnosol and of the Ethanol Extract from Lepichinia hastata. Phytomedicine, 54: 301-305.
5-Lipoxygenase-Inhibitor IC50 (uM)=2 * Antibiotic Encarnacion Dimayuga, R., Keer Garcia, S., Halfdan Nielsen, P., and Christophersen, C. 1989. Traditional Medicine of Baja California Sur (Mexico) III. Carnosol: A Diterpene Antibiotic from Lepechinia hastata. J. Ethnopharmacology, 31: 43-48, 1991. Antihepatotoxic Joyeux, M., Rolland, A., Fleurentin, J., Mortier, F., and Dorfman, P. 1989. Tert-Butyl Hydroperoxide-Induced Injury in Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs. Planta Medica 56(2): 171-173, 1990. AntiHIV J. Nat. Prod. 56: 1426. Antiinflammatory McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. Antilipoperoxidant Joyeux, M., Rolland, A., Fleurentin, J., Mortier, F., and Dorfman, P. 1989. Tert-Butyl Hydroperoxide-Induced Injury in Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs. Planta Medica 56(2): 171-173, 1990. Antimutagenic Economic & Medicinal Plant Research, 6: 235. Antioxidant McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. Antiradicular Joyeux, M., Rolland, A., Fleurentin, J., Mortier, F., and Dorfman, P. 1989. Tert-Butyl Hydroperoxide-Induced Injury in Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs. Planta Medica 56(2): 171-173, 1990. Antitumor McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. Antitumor-Promoter McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidicide Encarnacion Dimayuga, R., Keer Garcia, S., Halfdan Nielsen, P., and Christophersen, C. 1989. Traditional Medicine of Baja California Sur (Mexico) III. Carnosol: A Diterpene Antibiotic from Lepechinia hastata. J. Ethnopharmacology, 31: 43-48, 1991. Cyclooxygenase-Inhibitor IC50 (uM) =16 * Fungicide Encarnacion Dimayuga, R., Keer Garcia, S., Halfdan Nielsen, P., and Christophersen, C. 1989. Traditional Medicine of Baja California Sur (Mexico) III. Carnosol: A Diterpene Antibiotic from Lepechinia hastata. J. Ethnopharmacology, 31: 43-48, 1991. Metal-Chelator McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. Ornithine-Decarboxylase-Inhibitor McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. Pesticide * Protease-Inhibitor J. Nat. Prod. 56: 1426. Quinone-Reductase-Inducer 100 mg/kg ipr rat Singletary, K. W. 1996. Rosemary Extract and Carnosol Stimulate Rat Liver Glutathione-s-transferase and Quinone Reductase Activities. Cancer Lett., 100: 139-144.

^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Lepechinia hastata (Lamiaceae)

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