Syzygium claviflorum | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Activities: 108

Chemicals w/Activities: 5

All Chemicals: 6

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# Activity	Chemical Name	Part	Low PPM	High PPM	StdDev	^*Reference
5	ARJUNOLIC-ACID	Leaf	--	85.0	1.00	Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095.
Anticarcinogenic Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. AntiEBV * Antitumor Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Cardioprotective * Chemopreventive Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
1	ASIATIC-ACID	Leaf	--	40.0	--	Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095.
Collagenic *
22	BETULINIC-ACID	Leaf	--	205.0	-0.95	*
Anthelmintic * Antibacterial * Anticancer Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Anticarcinomic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiedemic * AntiHIV EC50=2.0 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. AntiHIV 14.8 uM * AntiHIV IC50=6.5 ug/ml * Antiinflammatory Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas. Planta Medica, 61: 9. Antileukemic Antimalarial IC50=19-26 ug/ml * Antimelanomic New York Times, 3/28/95. Antinociceptive * Antiplasmodial IC50=19-26 ug/ml * Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral 14.8 uM * Apoptotic * Cytotoxic 16.4 uM * Cytotoxic 50-100 ppm Biosyn. Prod. Cancer Chemotherapy (Petit et al) Phospholipase-A2-Inhibitor * Prostaglandin-Synthesis-Inhibitor 200 ug/ml Dunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497. Prostaglandin-Synthesis-Inhibitor IC50=101 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.
64	OLEANOLIC-ACID	Leaf	--	14.0	-0.83	Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095.
Abortifacient * Antiallergic * Antiarrhythmic 40 mg/kg * Antiatherosclerotic * Antibacterial MIC=625-1,250 ug/ml * Anticarcinomic Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Anticariogenic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Anticomplement IC40-50 0.01 mM/l gpg Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Anticomplement IC80-90 0.05 mM/l gpg Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Antiedemic IC36=40 mg/kg ipr rat * Antifertility * Antigingivitic MIC=625-1,250 ug/ml * Antihepatotoxic * AntiHIV EC50=1.7 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. AntiHIV IC50=21.8 ug/ml * Antihyperlipidemic * Antiinflammatory 40 mg/kg ipr Aquino, R., De Feo, V., De Simone, F., Pizza, C., and Cirino, G. Plant Metabolites. New Compounds And Anti-Inflammatory Activity Of Uncaria tomentosa. Journal of Natural Products, 54(2): 453-459, 1991. Antiischemic 40 mg/kg Antileukemic Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antileukotriene IC50=17 uM * Antimalarial IC50=70-89 ug/ml * Antinephritic IC50=19-24 uM * Antioxidant Balanehru, S. and Nagarajan, B. 1992. Intervention of Adriamycin Induced Free Radical Damage. Biochemistry International 28(4): 735-744, 1992. Antioxidant IC46=10 uM * Antiperiodontic MIC=625-1,250 ug/ml * Antiperoxidant IC30=200 ug/ml * AntiPGE2 IC50=24 uM * Antiplaque MIC=625-1,250 ug/ml * Antiplasmodial IC50=70-89 ug/ml * Antisarcomic * Antiseptic MIC=625-1,250 ug/ml * AntiTGF-beta IC50=19-24 uM * Antitumor * Antitumor (Breast) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Colon) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Kidney) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Lung) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Pancreas) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antiulcer >carbenoxolone * Antiviral EC50=1.7 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. Antiviral IC50=21.8 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. Aromatase-Inhibitor * Beta-Blocker * Beta-Glucuronidase-Inhibitor ~100 mg/kg * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardioprotective 40 mg/kg * Cardiotonic * COX-2-Inhibitor IC50=295 uM/ * COX-2-Inhibitor Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215. Cyclooxygenase-Inhibitor * Diuretic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Elastase-Inhibitor IC50=~15 uM * Hepatoprotective Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 211. Hypolipemic * Hypotensive * Immunomodulator * Leucocytogenic * NF-kB-Inhibitor * Phagocytotic * Piscicide ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes. Prostaglandin-Synthesis-Inhibitor igs mus * Sedative * Uterotonic * Vasopressor *
0	PALATANIC-ACID	Leaf	--	--	--	Fujioka, T., et. al. 1994. Anti-AIDS agents, 11. Betulinic Acid and Platanic Acid as Anti-HIV Principles from Syzygium claviflorum, and the Anti-HIV Activity of Structurally Related Triterpenoids. J. Nat. Prod. 57 2: 243-247.
89	URSOLIC-ACID	Leaf	--	20.0	-0.42	Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095.
Analgesic * Antialzheimeran Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215. Antiarrhythmic * Antiarthritic Planta Medica, 57: A56, 1991. Antibacterial * Anticancer Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215. Anticancer (Colon) Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215. Anticarcinomic Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Anticariogenic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Anticholestatic 28-100 mg/kg orl Shukla, B., Visen, P.K.S., Patnaik, G.K., Tripathi, S.C., Srimal, R.C., Dayal, R., and Dobhal, P.C. Hepatoprotective Activity in the Rat of Ursolic Acid Isolated from Eucalyptus Hybrid. Phytotherapy Research 6: 74-79, 1992. Anticomplement IC100 0.1 mM/l gpg Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Anticomplement IC80-90 0.05 mM/l gpg Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Antidiabetic Chemical Constituents of Oriental Herbs (3 diff. books) AntiEBV Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antiedemic * Antiescherichic * Antifibrosarcomic IC80=10 uM * Antihepatotoxic 5-20 mg/kg ipr Shukla, B., Visen, P.K.S., Patnaik, G.K., Tripathi, S.C., Srimal, R.C., Dayal, R., and Dobhal, P.C. Hepatoprotective Activity in the Rat of Ursolic Acid Isolated from Eucalyptus Hybrid. Phytotherapy Research 6: 74-79, 1992. Antihistaminic Tsuruga, T., Chun, Y.-T., Ebizuka, Y., and Sankawa, U. 1991. Biologically Active Constituents of Melaleuca leucadendron: Inhibitors of Induced Histamine Release from Rat Mast Cells. Chem. Pharm. Bull. 39(12): 3276-3278, 1991. AntiHIV 6.7 uM * AntiHIV EC50=2.0 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. AntiHIV IC50=6.5 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. AntiHIV IC85=18 ug/ml * Antihyperlipidemic * Antiinflammatory 1/3 indomethacin * Antiinflammatory IC24=500 mg/kg * Antileishmanic ED50=20 uM * Antileukemic IC50=2.5-17.8 ug/ml * Antilymphomic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antimalarial IC50=28-37 ug/ml * Antimetastatic IC80=10 uM * Antimutagenic IC57-80=80 mg/kg * Antinephritic IC50=6-7.5 uM * Antiobesity? Internat. J. Oriental Med. 16: 4. Antioxidant IC50=10 uM * Antiperoxidant IC35=200 ug/ml * Antiplasmodial IC50=28-37 ug/ml * Antiproliferative IC50=15-20 uM * Antistaphylococcic * AntiTGF-beta IC50=6-7.5 uM * Antithromboxane IC50=50 uM * Antitrypanosomic * Antitumor Cancer Research, 54: 701, 1994. Antitumor (brain) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Breast) 0.5% diet * Antitumor (Breast) IC50=15-20 uM * Antitumor (Cervix) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Colon) * Antitumor (Lung) * Antitumor (Ovary) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Stomach) IC50=15-20 uM * Antitumor-Promoter Planta Medica, 57: A56, 1991. Antiulcer Shukla, B., Visen, P.K.S., Patnaik, G.K., Tripathi, S.C., Srimal, R.C., Dayal, R., and Dobhal, P.C. Hepatoprotective Activity in the Rat of Ursolic Acid Isolated from Eucalyptus Hybrid. Phytotherapy Research 6: 74-79, 1992. Antiviral IC85=18 ug/ml * Aromatase-Inhibitor * Beta-Blocker * Beta-Glucuronidase-Inhibitor ~100 mg/kg * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidicide * Cardioprotective * Cardiotonic * Choleretic 5-20 mg/kg orl Shukla, B., Visen, P.K.S., Patnaik, G.K., Tripathi, S.C., Srimal, R.C., Dayal, R., and Dobhal, P.C. Hepatoprotective Activity in the Rat of Ursolic Acid Isolated from Eucalyptus Hybrid. Phytotherapy Research 6: 74-79, 1992. CNS-Depressant * COX-2-Inhibitor IC50=130 uM/ * Cyclooxygenase-Inhibitor Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215. Cytotoxic ED50=3.75 ug/ml * Cytotoxic 50 ppm * Cytotoxic 7.2 uM * Diuretic * Elastase-Inhibitor IC50=~15 uM * Hepatoprotective 1-100 ug/ml * Hepatoprotective 10 mg/kg * Hypoglycemic Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989. Hypotensive * Immunomodulator * Leucocytogenic * Lipoxygenase-Inhibitor IC50=0.18 mM * MMP-9-Inhibitor IC80=10 uM * Ornithine-Decarboxylase-Inhibitor * Pesticide * Piscicide * Potassium-Sparing 3 mg/rat Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Protease-Inhibitor IC85=18 ug/ml * Protisticide Chemical Express, 7: 285, 1992. Quinone-Reductase-Inducer 5 ug/ml Lee, S. K., Song, Y., Mata-Greenwood, E., Kelloff, G. J., Steele, V. E., Pezzuto, J. M. 1999. Modulation of in vitro Biomarkers of the Carcinogenic Process by Chemopreventive Agents. Anticancer Res., 19: 35-44. Sodium-Sparing 3 mg/rat Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. TOPO-2-Inhibitor * Trypanocide * Vasopressor *

^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Syzygium claviflorum (Myrtaceae)

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