Silybum marianum | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

Back to previous

Download a full report in PDF format

Common name(s)

Lady's Thistle, Milk Thistle

How used

GRAS

Data Views

Activities: 546

Chemicals w/Activities: 103

All Chemicals: 203

CSV Excel PDF

Exclude ubiquitous chemicals - View the list of ubiquitous chemicals

List of all chemical
Click on column headings to sort table by that column
# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
0	(+)-TAXIFOLIN	Fruit	--	--	--	*
0	(-)-SILANDRIN	Fruit	--	--	--	*
0	1-2-EPOXY-TRIDEC-3-ENE-5-7-9-11-TETRAYNE	Root	--	0.2	--	*
0	2,3-DEHYDROSILYCHRISTIN	Plant	--	--	--	J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991.
0	2,3-DEHYDROSILYCHRISTIN	Seed	--	--	--	*
0	2,3-DEHYDROSILYMARIN	Seed	--	--	--	*
0	2,3-DEHYDROSILYMARIN	Plant	--	--	--	J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991.
1	3-DEOXYSILYCHRISTIN	Seed	--	--	--	*
Antihepatotoxic Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 253.
1	3-DEOXYSILYCHRISTIN	Fruit	--	--	--	*
Antihepatotoxic Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 253.
1	3-DEOXYSILYCHRISTIN	Plant	--	--	--	*
Antihepatotoxic Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 253.
0	3-DEOXYSILYDIANIN	Seed	--	--	--	Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.
0	4'-5-7-TRIHYDROXY-3'-5'-DIMETHOXY-FLAVANONE	Fruit	--	--	--	*
0	4'-5-7-TRIHYDROXY-3'-5'-DIMETHOXY-FLAVANONE	Seed	--	--	--	*
4	5,7-DIHYDROXYCHROMONE	Plant	--	--	--	Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antibacterial Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antifeedant Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Herbicide IC100=6 mM Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Pesticide *
5	ALUMINUM	Plant	--	267.0	-0.23	Pedersen, M. 1987. Nutritional Herbology. Pederson Publishing. Bountiful, Utah. 377 pp.
Antisilicotic Medicinal and Poisonous Plants of the Tropics. Leeuwenberg, A.J.M., ed. Pudoc, Wageningen. 1987. Antivaginitic Martindale's 28th Candidicide Martindale's 28th Encephalopathic Martindale's 29th Pesticide *
5	ALUMINUM	Leaf	59.0	267.0	-0.49	*
Antisilicotic Medicinal and Poisonous Plants of the Tropics. Leeuwenberg, A.J.M., ed. Pudoc, Wageningen. 1987. Antivaginitic Martindale's 28th Candidicide Martindale's 28th Encephalopathic Martindale's 29th Pesticide *
101	APIGENIN	Fruit	--	--	--	*
11B-HSD-Inhibitor * AntiADD * Antiaflatoxin IC50=9.52 uM * Antiaflatoxin IC50=2.57 ppm * Antiaggregant * Antiaging * Antiallergic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiangiogenic 4 uM * Antiarrhythmic * Antibacterial Recio, M. C., Rios, J. L., and Villar, A., A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978-1988, Phytotherapy Research, 3(4), 1989, 117-125. Anticancer (Lung) * Anticomplementary * Antidermatitic Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp. Antiestrogenic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiherpetic 20-54 ug/ml * Antihistaminic IC50=10-35 uM * AntiHIV IC50=143 ug/ml * AntiHIV IC72=200 ug/ml * Antiinflammatory IC~65=1,000 uM * Antiinflammatory #NAME? * Antileukemic 20-50 uM * Antimelanomic 1-50 uM * Antimetastatic 1-50 uM * Antimutagenic ID50=10-40 nM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antimutagenic ID50=0.55 ug/ml * Antioxidant 1.5 x Vit. E * Antioxidant IC28.5=62.5 ug/ml * Antiperistaltic * Antiproliferant IC50=155 uM * Antiproliferant 1-50 uM * Antispasmodic EC50=1-5 uM * Antistress 10 mg/kg * Antithyroid Jim Duke's personal files. Antitumor 1-50 uM * Antitumor (Breast) 1-50 uM * Antitumor (Lung) * Antitumor (Skin) * Antiviral 20-54 ug/ml * Anxiolytic 10 mg/kg * Apoptotic 12-60 uM * Aromatase-Inhibitor IC65=1 uM/l Journal of Medicinal Food 2: 235.1999. Beta-Glucuronidase-Inhibitor IC50=~40 uM * Calcium-Antagonist? Biochimica & Biophysica Acta, 1115: 69, 1991. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Choleretic * CNS-Depressant * COX-1-Inhibitor IC65=1,000 uM * COX-2-Inhibitor <40 uM * COX-2-Inhibitor IC50=<15 uM * COX-2-Inhibitor IC>65=1,000 uM * Cyclooxygenase-Inhibitor * Cytochrome-P450-1A1-Inhibitor * Cytotoxic IC50=9.5 uM * Cytotoxic 1-50 uM * Cytotoxic IC88=10 ug/ml Planta Medica, 57: A113, 1991. Deiodinase-Inhibitor Jim Duke's personal files. Differentiator MIC=30 uM * Differentiator IC40=40 uM * Diuretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. DNA-Protective * Estrogenic 16% genistein * Estrogenic EC50=1 uM * Estrogenic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. HIF-1alpha-Inhibitor * Hyaluronidase-Inhibitor IC50+=50-250 uM * Hypotensive Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. ICAM-1-Inhibitor * IKK-Inhibitor * iNOS-Inhibitor IC50=<15 uM * Inotropic * Interleukin-6-Inhibitor * MAO-Inhibitor * MAPK-Inhibitor * Musculotropic Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Mutagenic * Myorelaxant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. NADH-Oxidase-Inhibitor * NF-kB-Inhibitor * NO-Synthase-Inhibitor 5-50 uM * Nodulation-Signal Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Ornithine-Decarboxylase-Inhibitor * P21-Inducer 10-70 uM * Pesticide * PKC-Inhibitor IC50=10 uM * Polyamine-Synthesis-Inhibitor * Progestational * Protein-Kinase-C-Inhibitor IC50=10-40 uM * PTK-Inhibitor 10-100 uM * Quinone-Reductase-Inducer 20 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216. Radioprotective * Sedative 30-100 mg/kg * Sunscreen * TNF-alpha-Inhibitor IC50=3.27 uM * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237. Topoisomerase-II-Inhibitor IC28=18 uM * Topoisomerase-II-Inhibitor IC45=180 uM * Topoisomerase-II-Inhibitor 50 ug/ml Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318. Uterotrophic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Vasodilator * VEGF-Inhibitor IC50=2-7 uM * Xanthine-Oxidase-Inhibitor 0.36 uM *
101	APIGENIN	Seed	--	--	--	*
11B-HSD-Inhibitor * AntiADD * Antiaflatoxin IC50=9.52 uM * Antiaflatoxin IC50=2.57 ppm * Antiaggregant * Antiaging * Antiallergic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiangiogenic 4 uM * Antiarrhythmic * Antibacterial Recio, M. C., Rios, J. L., and Villar, A., A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978-1988, Phytotherapy Research, 3(4), 1989, 117-125. Anticancer (Lung) * Anticomplementary * Antidermatitic Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp. Antiestrogenic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiherpetic 20-54 ug/ml * Antihistaminic IC50=10-35 uM * AntiHIV IC50=143 ug/ml * AntiHIV IC72=200 ug/ml * Antiinflammatory IC~65=1,000 uM * Antiinflammatory #NAME? * Antileukemic 20-50 uM * Antimelanomic 1-50 uM * Antimetastatic 1-50 uM * Antimutagenic ID50=10-40 nM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antimutagenic ID50=0.55 ug/ml * Antioxidant 1.5 x Vit. E * Antioxidant IC28.5=62.5 ug/ml * Antiperistaltic * Antiproliferant IC50=155 uM * Antiproliferant 1-50 uM * Antispasmodic EC50=1-5 uM * Antistress 10 mg/kg * Antithyroid Jim Duke's personal files. Antitumor 1-50 uM * Antitumor (Breast) 1-50 uM * Antitumor (Lung) * Antitumor (Skin) * Antiviral 20-54 ug/ml * Anxiolytic 10 mg/kg * Apoptotic 12-60 uM * Aromatase-Inhibitor IC65=1 uM/l Journal of Medicinal Food 2: 235.1999. Beta-Glucuronidase-Inhibitor IC50=~40 uM * Calcium-Antagonist? Biochimica & Biophysica Acta, 1115: 69, 1991. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Choleretic * CNS-Depressant * COX-1-Inhibitor IC65=1,000 uM * COX-2-Inhibitor <40 uM * COX-2-Inhibitor IC50=<15 uM * COX-2-Inhibitor IC>65=1,000 uM * Cyclooxygenase-Inhibitor * Cytochrome-P450-1A1-Inhibitor * Cytotoxic IC50=9.5 uM * Cytotoxic 1-50 uM * Cytotoxic IC88=10 ug/ml Planta Medica, 57: A113, 1991. Deiodinase-Inhibitor Jim Duke's personal files. Differentiator MIC=30 uM * Differentiator IC40=40 uM * Diuretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. DNA-Protective * Estrogenic 16% genistein * Estrogenic EC50=1 uM * Estrogenic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. HIF-1alpha-Inhibitor * Hyaluronidase-Inhibitor IC50+=50-250 uM * Hypotensive Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. ICAM-1-Inhibitor * IKK-Inhibitor * iNOS-Inhibitor IC50=<15 uM * Inotropic * Interleukin-6-Inhibitor * MAO-Inhibitor * MAPK-Inhibitor * Musculotropic Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Mutagenic * Myorelaxant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. NADH-Oxidase-Inhibitor * NF-kB-Inhibitor * NO-Synthase-Inhibitor 5-50 uM * Nodulation-Signal Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Ornithine-Decarboxylase-Inhibitor * P21-Inducer 10-70 uM * Pesticide * PKC-Inhibitor IC50=10 uM * Polyamine-Synthesis-Inhibitor * Progestational * Protein-Kinase-C-Inhibitor IC50=10-40 uM * PTK-Inhibitor 10-100 uM * Quinone-Reductase-Inducer 20 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216. Radioprotective * Sedative 30-100 mg/kg * Sunscreen * TNF-alpha-Inhibitor IC50=3.27 uM * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237. Topoisomerase-II-Inhibitor IC28=18 uM * Topoisomerase-II-Inhibitor IC45=180 uM * Topoisomerase-II-Inhibitor 50 ug/ml Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318. Uterotrophic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Vasodilator * VEGF-Inhibitor IC50=2-7 uM * Xanthine-Oxidase-Inhibitor 0.36 uM *
0	APIGENIN-7-O-BETA-D-(2''-O-ALPHA-L-RHAMNOSYL)-GALACTURONIDE	Flower	--	--	--	*
0	APIGENIN-7-O-BETA-D-GLUCURONIDE-6''-ETHYL-ESTER	Flower	--	--	--	*

List of all activity chemical
Click on column headings to sort table by that column
# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference

Show all rows.

^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Silybum marianum (Asteraceae)

Data Views