Fallopia japonica | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Giant Knotweed, Hu-Zhang, Japanese Knotweed, Mexican Bamboo

How used

Medicinal

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Activities: 342

Chemicals w/Activities: 32

All Chemicals: 59

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Exclude ubiquitous chemicals - View the list of ubiquitous chemicals

List of all chemical
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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
30	(+)-CATECHIN	Root	--	2.0	--	*
ACE-Inhibitor IC50=0.155 mM/l * ACE-Inhibitor 0.24 mg/ml rbt (weak activity) * Antiaggregant IC68=200 ug/ml * Anticoagulant * Anticomplementary 1/2 aspirin * AntiHIV EC50=4 ug/ml * Antiinflammatory IC50=40-943 uM (cf indomethacin IC50=1 uM) * Antimutagenic ID50=50-100 nM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antioxidant * Antiperoxidant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiprostaglandin IC50=40-943 uM (cf indomethacin IC50=1 uM) * Antiradicular Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiulcer * Beta-Adrenergic Receptor Blocker 10 uM (weak activity) Zhu, M., Phillipson, J. D., Greengrass, P. M., Bowery, N. E., Cai, Y. 1997. Plant Polyphenols: Biologically Active Compounds or Non-Selective Binders to Protein? Phytochemistry, 44(3): 441-447. cAMP-Phosphodiesterase-Inhibitor * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardiotonic * COX-1-Inhibitor IC50=183-279 uM (cf indomethacin IC50=1 uM) * COX-2-Inhibitor IC50=546-5,910 uM (cf indomethacin IC50=1 uM) * Cyclooxygenase-Inhibitor * Cytotoxic TC50=>100 ug/ml * Dermatitigenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Hemostat Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Hepatoprotective Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Immunostimulant Economic & Medicinal Plant Research, 1: 124. Neuroprotective 1-10 uM * NO-Inhibitor IC11=250 uM * Phagocytotic Economic & Medicinal Plant Research, 1: 124. Vasoconstrictor Leung, A.Y., Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, John Wiley & Sons, New York, 1980. Xanthine-Oxidase-Inhibitor Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
0	2,5-DIMETHYL-7-HYDROXYCHROMONE	Root	--	2.0	--	*
0	2,5-DIMETHYL-7-HYDROXYCHROMONE-7-MONOACETATE	Root	--	0.5	--	*
0	2-METHOXY-6-ACETYL-7-METHYL-JUGLONE	Root	--	3.0	--	*
0	2-METHOXY-6-ACETYL-7-METHYL-JUGLONE-MONOACETATE	Root	--	0.5	--	*
0	7-HYDROXY-4-METHOXY-5-METHYLCOUMARIN	Root	--	3.0	--	*
0	7-HYDROXY-4-METHOXY-5-METHYLCOUMARIN-8-MONOACETATE	Root	--	0.5	--	*
6	ANTHRAQUINONES	Root	--	--	--	Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.
Antilithic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Bird-Repellent Merck 11th Edition Carcinogenic * Laxative Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Litholytic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Toxic Jim Duke's personal files.
2	ARSENIC	Plant	--	--	--	Chem. & Pharm. Bull. 38: 2205.
Anorexic Forest H. Nielsen, USDA, Grand Forks, various publications. Pesticide *
0	BARIUM	Plant	14.0	32.0	-0.84	Chem. & Pharm. Bull. 38: 2205.
0	BROMINE	Plant	11.0	80.0	0.95	Chem. & Pharm. Bull. 38: 2205.
28	CALCIUM	Plant	11000.0	12000.0	-0.17	Chem. & Pharm. Bull. 38: 2205.
Antiallergic 500 mg/day * Antianxiety Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antiarrhythmic 500-1,500 mg * Antiarthritic 1,000 mg/day * Antiatherosclerotic 500 mg/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Anticlimacteric 1,000-1,500 mg/day * Antidepressant Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antidote (Aluminum) Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antidote (Lead) Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antihyperkinetic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antihypertensive * Antiinsomniac Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antimenopausal 1,000-1,500 mg/day * Antiobesity * Antiosteoporotic 500-2,000 mg/day * Antiperiodontitic 750 mg/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. AntiPMS 1 g/day * Antirheumatic 1,000 mg/day * Antistress 500-1,500 mg/day * Antitic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Anxiolytic 500-1,500 mg/day * Calcium-Channel-Blocker * Diuretic * Hypocholesterolemic 500 mg/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Hypotensive 1 g/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Laxative 1,000-1,200 mg * Tranquilizer 500-1,500 mg/day * Vasodilator *
7	CHLORINE	Plant	4000.0	6000.0	-0.10	Chem. & Pharm. Bull. 38: 2205.
Antibacterial Martindale's 29th Antiherpetic Martindale's 29th Antiseptic Martindale's 29th Antiviral Martindale's 29th Candidicide Martindale's 29th Fungicide Martindale's 29th Pesticide *
24	CHROMIUM	Plant	8.0	14.0	0.44	Chem. & Pharm. Bull. 38: 2205.
Amphiglycemic? Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antiacne * AntiAGE 200-1,000 ug Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000. Syndrome X - The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95 Antiaging 200-1,000 ug Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000. Syndrome X - The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95 Antiatherosclerotic 20 ug/day * AntiCFS 200 ug * Anticorneotic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antidiabetic 200-1,000 ug * Antidote (Lead) Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antifatigue 200 ug * Antiglycosuric 200-1,000 ug * Antiobesity 200-1,000 ug Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000. Syndrome X - The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95 Antisyndrome-X 200-800 ug Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000. Syndrome X - The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95 Antitriglyceride 20 ug/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Antitriglyceride 200-1,000 ug Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000. Syndrome X - The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95 Cardioprotective * Energizer * Hypocholesterolemic 200-1,000 ug Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000. Syndrome X - The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95 Hypocholesterolemic 20 ug/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Hypoglycemic 200-1,000 ug Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000. Syndrome X - The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95 Hypotensive 200-1,000 ug Challem, J., Berkson, Burt, and Smith, Melissa Dianne. 2000. Syndrome X - The complete nutritional program to prevent and reservse insulin resistance. John Wiley & Sons, New York. 272 pp. $24.95 Immunomodulator * Insulinogenic * Memorigenic *
10	CHRYSOPHANOL	Root	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Antibacterial Recently became Internat. J. Crude Drug Res. 28(1,2,3,4):1990, page 155. Antiseptic * Calcium-Antagonist 5/6 aloeemodin * Candidicide Recently became Internat. J. Crude Drug Res. 28(1,2,3,4):1990, page 155. Cathartic * Hemostat * Pesticide * Pigment Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Purgative ED50=>500 mg/kg orl mus * Termitifuge Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
0	CITREOROSEIN	Root	--	--	--	Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.
12	COPPER	Plant	9.0	10.0	-0.44	Chem. & Pharm. Bull. 38: 2205.
Antianemic * Antiarthritic * Antidiabetic 2-4 mg/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Antifatigue * Antiinflammatory Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Antinociceptive Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Antiosteoporotic * Cardioprotective * Contraceptive Martindale's 28th Hypocholesterolemic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Immunomodulator * Schizophrenigenic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp.
58	EMODIN	Root	4000.0	6700.0	0.60	*
AGEs-Inhibitor IC50=118 uM * Aldose-Reductase-Inhibitor IC50=15.9 uM * Allergenic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antiaggregant * Antiangiogenic * Antibacterial * Anticytomegalovirus ED50=1.1 ug/ml * Antifeedant Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Antiinflammatory 15 mg/kg * Antileukemic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antilymphomic * AntiMRSA MIC 2-64 ug/ml * Antimutagenic * Antineoplastic * Antiplaque ED50=1.1 ug/ml * Antiproliferant IC50=20-30 uM * Antisarcomic * Antiseptic * Antispasmodic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antisprout * Antitumor (Breast) * Antiulcer 15 mg/kg * Antivaginitic TIllotson, A. K. (with Abel, Jr., R., Tillotson, N.H., Bajracharya, V.M.B.). 2001. The One Earth Herbal Sourcebook: Everything You Need to Know about Chinese, Western, and Ayurvedic Herbal Treatments. Twin Streams, Kensington Publishing Corp. NY,NY. 596 pp Antiviral EC50=1.1 * Antiviral ED50=1.1 ug/ml * Cathartic Merck 11th Edition CNS-Depressant 15 mg/kg ipr mus * Collagenase-Inhibitor IC50=40 uM * COX-2-Inhibitor * Cytotoxic CD50=2.6 ug/ml * Differentiator IC50=20-30 uM * Estrogenic * Genotoxic * Gonadotropic * Hypolipidemic * Immunostimulant * Immunosuppressant * iNOS-Inhibitor * Leucocytogenic * MMP-2-Inhibitor * MMP-7-Inhibitor * MMP-9-Inhibitor * Mutagenic * NO-Inhibitor IC50=60.7 uM * Pesticide * PGE2-Inhibitor * Prostaglandin-Synthesis-Inhibitor IC50=23 uM/ml Mueller, S. O., Stopper, H. 1999. Characterization of the Genotoxicity of Anthraquinones in Mammalian Cells. Biochimica & Biophysica Acta, 1428: 406-414. Protein-Kinase-C-Inhibitor IC50=25 uM * PTK-Inhibitor IC50=19-37 uM * PTK-Inhibitor 10-100 uM * Purgative ED50=>500 mg/kg orl mus * Styptic * Topoisomerase-II-Inhibitor 1 mM Muller, S. O., Eckert, I., Lutz, W. K., Stopper, H. 1996. Genotoxicity of the Laxative Drug Components Emodin, Aloe-emodin and Danthron in Mammalian Cells: Topoisomerase II Mediated? Mutat Res, 371: 165-173. Topoisomerase-II-Inhibitor IC50=7 uM/ml Mueller, S. O., Stopper, H. 1999. Characterization of the Genotoxicity of Anthraquinones in Mammalian Cells. Biochimica & Biophysica Acta, 1428: 406-414. Trichomonicide * Tyrosine-Kinase-Inhibitor * Vasodilator * Vasorelaxant *
0	EMODIN-8-BETA-D-GLUCOSIDE	Root	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
2	EMODIN-8-GLUCOSIDE	Root	--	--	--	Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Pesticide * Spermistat Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Fallopia japonica (Polygonaceae)

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