Baptisia tinctoria | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Wild Indigo

How used

Medicinal

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Activities: 182

Chemicals w/Activities: 11

All Chemicals: 25

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
0	13-HYDROXYSPARTEINE	Plant	--	--	--	*
11	ANAGYRINE	Plant	--	--	--	*
Antiarrhythmic * Antiedemic * AntiRSV * Antiviral * Cardiotonic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Cathartic * Diuretic * Nematistat Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Oxytoxic * Tachycardic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Teratogenic 30 mg/kg *
0	BAPTISINE	Root	--	--	--	*
0	BAPTISOL	Leaf	--	--	--	*
32	BIOCHANIN-A	Plant	--	--	--	*
17-beta-hydroxysteroid dehydrogenase-Inhibitor 10.8 uM * 5-Alpha-Reductase-Inhibitor IC50=35 uM * 5-Alpha-Reductase-Inhibitor IC>80=100 uM * Alpha-Reductase-Inhibitor IC50=~35 uM * Antialcoholic * Anticarcinogenic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Anticephalagic * Antimutagenic Economic & Medicinal Plant Research, 6: 235. Antiproliferant * Antiprostatadenomic 8-27 ug/ml Medline (post 1990 searches filed in my computer) Antiprostatitic IC50=~35 uM * Antitumor (GI) * Antitumor (Lung) * Apoptotic >150 uM * Aromatase-Inhibitor IC45=1 uM/l Journal of Medicinal Food 2: 235.1999. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Chemopreventive Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. ER-Beta-Binder * Estrogen-Agonist 0.1-1 uM/l Journal of Medicinal Food 2: 139.1999. Estrogenic 0.1 uM * Estrogenic EC50=0.1-25 uM/l * Flatulent * Fungicide ED50=250-350 ug/ml Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Fungistat IC50=200 uM * Herbicide-Safener Chau (1985) in Purseglove et al. Acta Botanica Sinica, 2. Hypocholesterolemic * Hypolipidemic * Pesticide * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237. Topoisomerase-II-Inhibitor 50 ug/ml Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318. Uterotrophic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. VAM-Simulant Chau (1985) in Purseglove et al. Acta Botanica Sinica, 2.
0	BIOCHANIN-A-7-O-RHAMNOGLUCOSIDE	Plant	--	--	--	*
10	CYTISINE	Leaf	--	--	--	*
Antiinflammatory * Hallucinogenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Molluscicide * Nematistat Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Pesticide * Pressor Collins, D.J., Culvenor, C.C.J., Lamberton, J.A., Loder, J.W. and Price, J.R., Plants for Medicines, CSIRO, East Melbourne, Australia, 1990, 303 pp. Psychoactive * Respirastimulant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Teratogenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Toxic Mitchell, J. and Rook, A.J. 1923. Botanical Dermatology: plants and plant products injurious to the skin. Vancouver: Greengrass, 1979. xiii, 787 p.: ill.
10	CYTISINE	Root	--	--	--	*
Antiinflammatory * Hallucinogenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Molluscicide * Nematistat Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Pesticide * Pressor Collins, D.J., Culvenor, C.C.J., Lamberton, J.A., Loder, J.W. and Price, J.R., Plants for Medicines, CSIRO, East Melbourne, Australia, 1990, 303 pp. Psychoactive * Respirastimulant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Teratogenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Toxic Mitchell, J. and Rook, A.J. 1923. Botanical Dermatology: plants and plant products injurious to the skin. Vancouver: Greengrass, 1979. xiii, 787 p.: ill.
10	CYTISINE	Stem	--	--	--	*
Antiinflammatory * Hallucinogenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Molluscicide * Nematistat Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Pesticide * Pressor Collins, D.J., Culvenor, C.C.J., Lamberton, J.A., Loder, J.W. and Price, J.R., Plants for Medicines, CSIRO, East Melbourne, Australia, 1990, 303 pp. Psychoactive * Respirastimulant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Teratogenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Toxic Mitchell, J. and Rook, A.J. 1923. Botanical Dermatology: plants and plant products injurious to the skin. Vancouver: Greengrass, 1979. xiii, 787 p.: ill.
81	GENISTEIN	Leaf	--	--	--	*
Abortifacient Cooper-Driver, G. A., Chemical substances in plants toxic to animals, pp. 213-47 in Rechcigl, M., Jr., ed. CRC Handbook of Naturally Occurring Food Toxicants, CRC Press, Boca Raton, 1983, 339 pp. Aldose-Reductase-Inhibitor IC50=10 uM * Alpha-Reductase-Inhibitor IC50=35 uM * Antiaggregant 1-10 ug/ml Medline (post 1990 searches filed in my computer) Antiangiogenic 150 uM * Antiatherosclerotic Journal of Medicinal Food 2: 163.1999. Anticancer (Breast) IC50=2.6-6.7 ug/ml * Anticarcinomic (Breast) IC50=?640 uM Medline (post 1990 searches filed in my computer) Anticlimacteric Duke, J. A. Writeups or information summaries on approximately 2,000 economic plants, USDA, ARS, Beltsville, MD 20705. Antiendoccytotic 100 ug/ml Medline (post 1990 searches filed in my computer) Antiestrogenic * Antifertility * Antihemolytic * Antiimplantation * Antiinflammatory Journal of Medicinal Food 2: 179.1999. Antiischemic Medline (post 1990 searches filed in my computer) Antileukemic >50 ug/ml (185 uM) * Antileukemic IC50=0.010 ug/ml Life Sciences 55: 1061. Antileukotriene IC50=10-15 uM Medline (post 1990 searches filed in my computer) Antilymphomic * Antimelanomic Medline (post 1990 searches filed in my computer) Antimicrobial * Antimitogenic IC50=12 uM * Antimutagenic ID50=50-100 nM Maga, J.A. Contribution of Phenolic Compounds to Smoke Flavor. Phenolic Compounds in Food and Their Effects on Health, Ch.13. Antineuroblastomic * Antiosteoporotic * Antioxidant Phenolic Compounds in Food and Their Effects on Health, 64. Antiproliferative 5-45 uM * Antiprostatadenomic 8-27 ug/ml Medline (post 1990 searches filed in my computer) Antiprostatitic IC50=35 uM * Antispasmodic IC50=34 uM * Antitumor (Breast) * Antitumor (GI) * Antitumor (Ovary) * Antitumor (Prostate) * Antitumor (Stomach) * Antiulcer? * Antiviral * Apoptotic * Aromatase-Inhibitor IC30=1 uM/l Journal of Medicinal Food 2: 235.1999. Calcium-Antagonist 50 uM gpg * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardioprotective Journal of Medicinal Food 2: 163.1999. Catechol-O-Methyltransferase-Inhibitor * Cytotoxic >50 ug/ml (185 uM) Medline (post 1990 searches filed in my computer) Cytotoxic IC89=10 ug/ml Planta Medica, 57: A113, 1991. DOPA-Decarboxylase-Inhibitor * Estrogen-Agonist 0.1-1 uM/l Journal of Medicinal Food 2: 139.1999. Estrogenic EC50=0.1-25 uM/l * Flatulent * Fungicide 2.5 mM Geibel, M. 1994. Sensitivity of the Fungus Cytospora persoonii to the Flavonoids of Prunus cerasus. Phytochemistry. 38(3): 599-601. 1995. Fungicide ED50=50->100 * Fungistat IC34=200 uM * Histidine-Kinase-Inhibitor IC50=110 uM Medline (post 1990 searches filed in my computer) Hypocholesterolemic ED50=0.5 mg/kg * Immunostimulant 2-20 mg/kg orl mus * Lipase-Inhibitor * MAO-Inhibitor IC50=60-140 uM * MAO-Inhibitor IC50=95 * MDR-Inhibitor 200 uM Castro, A. F., Altenberg, G. A. 1997. Inhibition of Drug Transport by Genistein in Multidrug-Resistant Cell Expressing P-Glycoprotein. Biochem Pharmacol, 53(1): 89-93. NADH-Ubiquinone-Oxidoreductase-Inhibitor * Natriuretic * Ornithine-Decarboxylase-Inhibitor * Peroxidase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide * Phytoalexin Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Pituitary-sensitizer Medline (post 1990 searches filed in my computer) PTK-Inhibitor 10-100 uM * Quinone-Reductase-Inducer IC50=4.6 ug/ml * Topoisomerase-I-Inhibitor IC50=250 ppm * Topoisomerase-I-Inhibitor 1-10 ug/ml Okura, A., Arakawa, H., Oka, H., Yoshinari, T., Monden, Y. 1988. Effect of Genistein on Topoisomerase Activity and on the Growth of [VAL 12]HA-RAS-Transformed NIH 3T3 Cells. Biochem Biophys Res Commun, 157: 183-189. Topoisomerase-II-Inhibitor 2-7.5 ug/ml * Topoisomerase-II-Inhibitor IC50=30 ug/ml Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225. Topoisomerase-II-Inhibitor 20 uM Markovits, J., et al. 1989. Inhibitory Effects of the Tyrosine Kinase Inhibitor Genistein on Mammalian DNA Topoisomerase II. Cancer Research, 49: 5111-5117. Topoisomerase-II-Inhibitor IC50=1-150 uM * Topoisomerase-II-Poison Journal of Medicinal Food 2: 167.1999. Trypanosomastat Medline (post 1990 searches filed in my computer) Tyrosine-Kinase-Inhibitor * Uterotrophic ED50=0.5 mg/kg * Uterotrophic EC50=0.1-25 uM/l * VEGF-Inhibitor *
0	GENISTEIN-7-O-RHAMNOGLUCOSIDE	Plant	--	--	--	*
0	GUM	Plant	--	--	--	*
78	LUTEOLIN	Plant	--	--	--	*
Aldose-Reductase-Inhibitor IC50=0.45 uM rat * Aldose-Reductase-Inhibitor EC=3 ppm Shin, K.H., Chung, M.S., Chae, Y.J., Yoon, K.Y., Cho, T.S. 1992. A survey for aldose reductase inhibition of herbal medicines. Fitoterapia 64(2): 130, 1993. Antiallergic Antiangiogenic IC60-75=10 uM * Antiatherogenic * Antibacterial MIC=500 ug/ml Planta Medica, 57: A43, 1991. Anticarcinogenic * Anticarcinomic Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Anticataract EC=3 ppm Shin, K.H., Chung, M.S., Chae, Y.J., Yoon, K.Y., Cho, T.S. 1992. A survey for aldose reductase inhibition of herbal medicines. Fitoterapia 64(2): 130, 1993. Anticomplementary Antidermatic Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp. Antiestrogenic * Antifeedant IC52=<1,000 ppm diet Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Antiherpetic 11-23 ug/ml * Antihistaminic <10-15 uM * AntiHIV * Antiinflammatory #NAME? Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Antileukemic 20-50 uM * Antilymphomic Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antimelanomic Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antimutagenic ID50=0.44 ug/ml * Antimutagenic ID50=2-5 nM * Antinociceptive * Antioxidant IC50=10 uM * Antipolio Economic & Medicinal Plant Research, 5: 197. Antiproliferant * Antispasmodic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antitumor 1-50 uM * Antitumor (brain) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Colon) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Kidney) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Lung) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Ovary) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Pancreas) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Skin) 20 uM * Antitumor (Stomach) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Thyroid) 12-50 uM * Antitussive * Antiviral 11-23 ug/ml * Aphidifuge * Apoptotic 12-50 uM * Aromatase-Inhibitor IC35=1 uM/l Journal of Medicinal Food 2: 235.1999. Beta-Glucuronidase-Inhibitor IC50=~40 uM * Calcium-Antagonist IC50=1.2 uM rbt * Cancer-Preventive * Chemopreventive * Choleretic * Cytotoxic 1-50 uM * Deiodinase-Inhibitor Jim Duke's personal files. Differentiator IC>40=40 uM * Diuretic Jim Duke's personal files. Estrogenic 58% genistein * Hepatoprotective * Hyaluronidase-Inhibitor IC50+=100-250 uM * Hypocholesterolemic * ICAM-1-Inhibitor * IKK-Inhibitor * iNOS-Inhibitor * Iodothyronine-Deiodinase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Lipoxygenase-Inhibitor * MAPK-Inhibitor * Metalloproteinase-Inhibitor * MMP-9-Inhibitor 20 uM * Myorelaxant * NEP-Inhibitor IC50=>42 uM * NF-kB-Inhibitor * NO-Inhibitor * Pesticide * Proliferant * Prostaglandin-Synthetase-Inhibitor * Protein-Kinase-C-Inhibitor IC70=50 uM * PTK-Inhibitor 10-100 uM * Succinoxidase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. TNF-alpha-Inhibitor IC50=14.44 uM * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237. Vasodilator * VEGF-Inhibitor IC50=2-7 uM * Xanthine-Oxidase-Inhibitor IC50=0.11 ug/ml Chem. & Pharm. Bull. 38: 1772.
0	LUTEOLIN-7-O-RHAMNOGLUCOSIDE	Plant	--	--	--	*
0	METHYL-CYTISINE	Leaf	--	--	--	*
0	METHYL-CYTISINE	Stem	--	--	--	*
0	OROBOL	Plant	--	--	--	*
0	OROBOL-7-O-RHAMNOGLUCOSIDE	Plant	--	--	--	*
3	PSEUDOBAPTIGENIN	Leaf	--	--	--	*
Antiarthritic * Herbistat Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide *
0	PSEUDOBAPTIGENIN-7-O-RHAMNOGLUCOSIDE	Plant	--	--	--	*

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Baptisia tinctoria (Fabaceae)

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