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Chemical ID
SAFROLE
Ubiquitous
No
| Dosage | Reference |
|---|---|
| LD50=1,950 (orl rat) | |
| LD50=2,350 (orl mus) | Merck 11th Edition |
| Activity | Dosage | Reference |
|---|---|---|
| Anesthetic | not available | Duke, 1992 * |
| Antiaggregant | IC50=110 uM | Janssens, J., Laekeman, G.M., Pieters, L.A.C., Totte, J., Herman, A.G., and Vlietinck, A.J. 1990. Nutmeg Oil: Identification and Quantitation of its Most Active Constituents as Inhibitors of Platelet Aggregation. J.of Ethnopharmacology, 29: 179-188, 1990. |
| Antibacterial | not available | Duke, 1992 * |
| Anticonvulsant | not available | Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. |
| Antiseptic | not available | Merck 11th Edition |
| Calcium-Antagonist | IC50=57 uM gpg | Duke, 1992 * |
| Calcium-Antagonist | IC50=58 uM | Duke, 1992 * |
| Cancer-Preventive | not available | Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. |
| Carcinogenic | not available | Merck 11th Edition |
| Carminative | not available | Duke, 1992 * |
| CNS-Depressant | not available | Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. |
| CNS-Stimulant | not available | List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979. |
| Controlled | not available | HerbalGram No. 20, page 15. |
| Cytochrome-P450-Inducer | not available | Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. |
| Cytochrome-P488-Inducer | not available | Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. |
| DNA-Binder | not available | Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. |
| Hepatocarcinogenic | not available | Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. |
| Hepatoregenerative | not available | CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses |
| Hepatotoxic | not available | Martindale's 29th |
| Hypothermic | not available | Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. |
| Plant Name | Plant Part | Low Parts Per Million | High Parts Per Million | Standard Deviation | Reference |
|---|---|---|---|---|---|
| Hamamelis virginiana | Leaf | not available | 10.0 | -0.7 | Duke, 1992 * |
| Illicium verum | Fruit | not available | not available | not available | Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. |
| Illicium verum | Plant | not available | not available | not available | Duke, 1992 * |
| Juniperus virginiana | Leaf | not available | not available | not available | Duke, 1992 * |
| Myristica fragrans | Essential Oil | 1000.0 | 33000.0 | not available | Duke, 1992 * |
| Myristica fragrans | Seed | 120.0 | 2720.0 | not available | Duke, 1992 * |
| Myristica fragrans | Seed Essent. Oil | 1000.0 | 60000.0 | not available | Duke, 1992 * |
| Ocimum basilicum | Plant | 60.0 | 400.0 | 0.8 | Duke, 1992 * |
| Pimpinella anisum | Essential Oil | not available | not available | not available | Duke, 1992 * |
| Piper auritum | Leaf | 3290.0 | 4930.0 | 1.4 | Duke, 1992 * |
| Piper cubeba | Fruit | not available | not available | not available | Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980. |
| Piper nigrum | Fruit Essent. Oil | not available | not available | not available | Duke, 1992 * |
| Piper nigrum | Fruit | not available | not available | not available | Duke, 1992 * |
| Rheum palmatum | Rhizome | not available | 2.0 | not available | Duke, 1992 * |
| Rosmarinus officinalis | Plant | 32.0 | 95.0 | -1.4 | Duke, 1992 * |
| Sassafras albidum | Leaf | not available | 0.0 | -0.7 | Duke, 1992 * |
| Sassafras albidum | Root | 8000.0 | 81000.0 | not available | Duke, 1992 * |
| Tamarindus indica | Fruit | not available | not available | not available | Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. |
| Umbellularia californica | Plant | not available | not available | not available | Duke, 1992 * |