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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
  1. Home
  2. SAFROLE

SAFROLE

Chemical ID
SAFROLE
Ubiquitous
No
List of known dosages
Dosage Reference
LD50=1,950 (orl rat)
LD50=2,350 (orl mus) Merck 11th Edition
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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Dosage Reference
Anesthetic *
Antiaggregant IC50=110 uM Janssens, J., Laekeman, G.M., Pieters, L.A.C., Totte, J., Herman, A.G., and Vlietinck, A.J. 1990. Nutmeg Oil: Identification and Quantitation of its Most Active Constituents as Inhibitors of Platelet Aggregation. J.of Ethnopharmacology, 29: 179-188, 1990.
Antibacterial *
Anticonvulsant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antiseptic Merck 11th Edition
Calcium-Antagonist IC50=58 uM *
Calcium-Antagonist IC50=57 uM gpg *
Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Carcinogenic Merck 11th Edition
Carminative *
CNS-Depressant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
CNS-Stimulant List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Controlled HerbalGram No. 20, page 15.
Cytochrome-P450-Inducer Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
Cytochrome-P488-Inducer Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
DNA-Binder Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Hepatocarcinogenic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
Hepatoregenerative CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses
Hepatotoxic Martindale's 29th
Hypothermic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name Plant Part Low Parts Per Million High Parts Per Million Standard Deviation Reference
Agastache rugosa Essential Oil Jim Duke's personal files.
Anethum graveolens Plant 125.0 360.0 0.6 *
Anethum graveolens Seed Essent. Oil *
Angelica sinensis Root Pedersen, M. 1987. Nutritional Herbology. Pederson Publishing. Bountiful, Utah. 377 pp.
Angelica sinensis Root Essent. Oil Jim Duke's personal files.
Asiasarum heterotropoides Root *
Asiasarum sieboldii Root *
Camellia sinensis Leaf *
Cananga odorata Flower *
Chenopodium ambrosioides Plant *
Cinnamomum aromaticum Plant *
Cinnamomum camphora Leaf *
Cinnamomum verum Leaf Essent. Oil 6500.0 23000.0 *
Cinnamomum verum Bark Essent. Oil *
Cinnamomum verum Stem Bark *
Cinnamomum verum Root Bark *
Cinnamomum verum Plant *
Cinnamomum verum Leaf Wealth of India.
Cinnamomum verum Bark Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.
Ephedra sinica Shoot 2.0 *