Chemical PULEGONE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

PULEGONE

Ubiquitous

List of known dosages
Dosage	Reference
LD50=150 (ipr mus)
LD50=470 mg/kg (orl rat)	Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
LD50=3,090 mg/kg (der rbt)	Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Sort descending	Dosage	Reference
AChE-Inhibitor	not available	Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8.
Antiacetylcholinesterase	IC50=0.9 mM	Duke, 1992 *
Antiacetylcholinesterase	IC50=136 ug/ml	Duke, 1992 *
Antialzheimeran?	not available	Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8.
Antibacterial	not available	Economou, D., and Nahrstedt, A. 1991. Chemical, Physiological, and Toxicological Aspects of the Essential Oil of Some Species of the Genus Bystropogon*. Planta Medica, 57: 347, 1991.
Anticholinesterase	not available	Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8.
Antihistaminic	not available	Ortiz De Urbina, A.V., Martin, M.L., Montero, M.J., Carron, R., Sevilla, M.A., San Roman, L. 1989. Antihistaminic activity of pulegone on the guinea-pig ileum. J. Pharm. Pharmacol. 42: 295-296, 1990.
Antipyretic	not available	Duke, 1992 *
Avifuge	not available	Duke, 1992 *
Cancer-Preventive	not available	Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Candidicide	not available	Economou, D., and Nahrstedt, A. 1991. Chemical, Physiological, and Toxicological Aspects of the Essential Oil of Some Species of the Genus Bystropogon*. Planta Medica, 57: 347, 1991.
Cerebrotoxic	orl man	J. Aromatherapy 4: 24.
Encephalopathic	80 mg/kg orl rat	Lawrence Review of Natural Products, Jan-92.
FLavor	FEMA 5-30	Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry
Fungicide	not available	Economou, D., and Nahrstedt, A. 1991. Chemical, Physiological, and Toxicological Aspects of the Essential Oil of Some Species of the Genus Bystropogon*. Planta Medica, 57: 347, 1991.
Glutathionalytic	not available	Lawrence Review of Natural Products, Jan-92.
Hallucinogenic	not available	R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R.
Hepatotoxic	not available	Lewis, E.J. and Friedrich, E.C. 1989. The Essential Oil of Poliomintha incana. Planta Medica 56(2): 224-226, 1990.
Herbicide	IC50=1.5 uM	Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp.
Insecticide	not available	Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8.

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name Sort descending	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Acinos suaveolens	Shoot	not available	690400.0	5.2	Jim Duke's personal files.
Acinos suaveolens	Essential Oil	not available	332200.0	-0.3	Jim Duke's personal files.
Agastache pallidiflora	Leaf	not available	not available	not available	Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980.
Agastache urticifolia	Plant	not available	1138.0	-0.5	Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980.
Agathosma betulina	Leaf	1650.0	2750.0	-0.3	Duke, 1992 *
Barosma betulina	Leaf	1650.0	2750.0	-0.3	Duke, 1992 *
Calamintha nepeta	Leaf	not available	3360.0	-0.2	Akgul, A., De Pooter, H.L., and De Buyck, L.F. 1991. The Essential Oils of Calamintha nepeta subsp. glandulosa and Ziziphora clinopodioides from Turkey. J. Ess. Oil Res., 3: 7-10.
Calamintha nepeta	Plant	not available	2760.0	-0.3	J. Ethnopharmacology, 39: 167.
Capsicum annuum	Fruit	not available	not available	not available	Chemical Constituents of Oriental Herbs (3 diff. books)
Capsicum frutescens	Fruit	not available	not available	not available	Duke, 1992 *
Dracocephalum thymiflora	Plant	not available	280.0	-0.6	Duke, 1992 *
Ephedra sinica	Shoot	not available	7.0	-0.3	Duke, 1992 *
Hedeoma drummondii	Plant	5500.0	7240.0	0.2	Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980.
Hedeoma pulegioides	Pollen Or Spore	not available	823000.0	not available	Duke, 1992 *
Hedeoma pulegioides	Plant	3678.0	27600.0	2.4	Duke, 1992 *
Hedeoma pulegioides	Leaf	17.0	50.0	-0.7	Duke, 1992 *
Hedeoma pulegioides	Stem	0.5	3.8	not available	Duke, 1992 *
Hedeoma pulegioides	Essential Oil	not available	not available	not available	Duke, 1992 *
Lycopus virginicus	Plant	10.0	24.0	-0.6	Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980.
Mentha aquatica	Shoot	not available	not available	not available	Umemoto, K., Arai, T., Nii, H. and Furukawa, K. 1993. A New Chemotype of Mentha aquatica Containing Sesquiterpene Alcohols as Major Components. Nippon Nogeikagaku Kaishi 67(10): 1417-1419.