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Chemical ID
PULEGONE
Ubiquitous
No
| Dosage | Reference |
|---|---|
| LD50=150 (ipr mus) | |
| LD50=470 mg/kg (orl rat) | Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. |
| LD50=3,090 mg/kg (der rbt) | Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. |
| Activity | Dosage | Reference |
|---|---|---|
| AChE-Inhibitor | not available | Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8. |
| Antiacetylcholinesterase | IC50=0.9 mM | Duke, 1992 * |
| Antiacetylcholinesterase | IC50=136 ug/ml | Duke, 1992 * |
| Antialzheimeran? | not available | Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8. |
| Antibacterial | not available | Economou, D., and Nahrstedt, A. 1991. Chemical, Physiological, and Toxicological Aspects of the Essential Oil of Some Species of the Genus Bystropogon*. Planta Medica, 57: 347, 1991. |
| Anticholinesterase | not available | Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8. |
| Antihistaminic | not available | Ortiz De Urbina, A.V., Martin, M.L., Montero, M.J., Carron, R., Sevilla, M.A., San Roman, L. 1989. Antihistaminic activity of pulegone on the guinea-pig ileum. J. Pharm. Pharmacol. 42: 295-296, 1990. |
| Antipyretic | not available | Duke, 1992 * |
| Avifuge | not available | Duke, 1992 * |
| Cancer-Preventive | not available | Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. |
| Candidicide | not available | Economou, D., and Nahrstedt, A. 1991. Chemical, Physiological, and Toxicological Aspects of the Essential Oil of Some Species of the Genus Bystropogon*. Planta Medica, 57: 347, 1991. |
| Cerebrotoxic | orl man | J. Aromatherapy 4: 24. |
| Encephalopathic | 80 mg/kg orl rat | Lawrence Review of Natural Products, Jan-92. |
| FLavor | FEMA 5-30 | Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry |
| Fungicide | not available | Economou, D., and Nahrstedt, A. 1991. Chemical, Physiological, and Toxicological Aspects of the Essential Oil of Some Species of the Genus Bystropogon*. Planta Medica, 57: 347, 1991. |
| Glutathionalytic | not available | Lawrence Review of Natural Products, Jan-92. |
| Hallucinogenic | not available | R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R. |
| Hepatotoxic | not available | Lewis, E.J. and Friedrich, E.C. 1989. The Essential Oil of Poliomintha incana. Planta Medica 56(2): 224-226, 1990. |
| Herbicide | IC50=1.5 uM | Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. |
| Insecticide | not available | Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8. |
| Plant Name | Plant Part | Low Parts Per Million | High Parts Per Million | Standard Deviation | Reference |
|---|---|---|---|---|---|
| Acinos suaveolens | Shoot | not available | 690400.0 | 5.2 | Jim Duke's personal files. |
| Acinos suaveolens | Essential Oil | not available | 332200.0 | -0.3 | Jim Duke's personal files. |
| Agastache pallidiflora | Leaf | not available | not available | not available | Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980. |
| Agastache urticifolia | Plant | not available | 1138.0 | -0.5 | Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980. |
| Agathosma betulina | Leaf | 1650.0 | 2750.0 | -0.3 | Duke, 1992 * |
| Barosma betulina | Leaf | 1650.0 | 2750.0 | -0.3 | Duke, 1992 * |
| Calamintha nepeta | Leaf | not available | 3360.0 | -0.2 | Akgul, A., De Pooter, H.L., and De Buyck, L.F. 1991. The Essential Oils of Calamintha nepeta subsp. glandulosa and Ziziphora clinopodioides from Turkey. J. Ess. Oil Res., 3: 7-10. |
| Calamintha nepeta | Plant | not available | 2760.0 | -0.3 | J. Ethnopharmacology, 39: 167. |
| Capsicum annuum | Fruit | not available | not available | not available | Chemical Constituents of Oriental Herbs (3 diff. books) |
| Capsicum frutescens | Fruit | not available | not available | not available | Duke, 1992 * |
| Dracocephalum thymiflora | Plant | not available | 280.0 | -0.6 | Duke, 1992 * |
| Ephedra sinica | Shoot | not available | 7.0 | -0.3 | Duke, 1992 * |
| Hedeoma drummondii | Plant | 5500.0 | 7240.0 | 0.2 | Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980. |
| Hedeoma pulegioides | Plant | 3678.0 | 27600.0 | 2.4 | Duke, 1992 * |
| Hedeoma pulegioides | Leaf | 17.0 | 50.0 | -0.7 | Duke, 1992 * |
| Hedeoma pulegioides | Stem | 0.5 | 3.8 | not available | Duke, 1992 * |
| Hedeoma pulegioides | Essential Oil | not available | not available | not available | Duke, 1992 * |
| Hedeoma pulegioides | Pollen Or Spore | not available | 823000.0 | not available | Duke, 1992 * |
| Lycopus virginicus | Plant | 10.0 | 24.0 | -0.6 | Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980. |
| Mentha aquatica | Leaf | 54.0 | 153.0 | -0.7 | Duke, 1992 * |