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Chemical PULEGONE

Chemical ID
PULEGONE
Ubiquitous
No
List of known dosages
Dosage Reference
LD50=150 (ipr mus)
LD50=470 mg/kg (orl rat) Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
LD50=3,090 mg/kg (der rbt) Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Dosage Reference
AChE-Inhibitor not available Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8.
Antiacetylcholinesterase IC50=0.9 mM Duke, 1992 *
Antiacetylcholinesterase IC50=136 ug/ml Duke, 1992 *
Antialzheimeran? not available Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8.
Antibacterial not available Economou, D., and Nahrstedt, A. 1991. Chemical, Physiological, and Toxicological Aspects of the Essential Oil of Some Species of the Genus Bystropogon*. Planta Medica, 57: 347, 1991.
Anticholinesterase not available Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8.
Antihistaminic not available Ortiz De Urbina, A.V., Martin, M.L., Montero, M.J., Carron, R., Sevilla, M.A., San Roman, L. 1989. Antihistaminic activity of pulegone on the guinea-pig ileum. J. Pharm. Pharmacol. 42: 295-296, 1990.
Antipyretic not available Duke, 1992 *
Avifuge not available Duke, 1992 *
Cancer-Preventive not available Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Candidicide not available Economou, D., and Nahrstedt, A. 1991. Chemical, Physiological, and Toxicological Aspects of the Essential Oil of Some Species of the Genus Bystropogon*. Planta Medica, 57: 347, 1991.
Cerebrotoxic orl man J. Aromatherapy 4: 24.
Encephalopathic 80 mg/kg orl rat Lawrence Review of Natural Products, Jan-92.
FLavor FEMA 5-30 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry
Fungicide not available Economou, D., and Nahrstedt, A. 1991. Chemical, Physiological, and Toxicological Aspects of the Essential Oil of Some Species of the Genus Bystropogon*. Planta Medica, 57: 347, 1991.
Glutathionalytic not available Lawrence Review of Natural Products, Jan-92.
Hallucinogenic not available R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R.
Hepatotoxic not available Lewis, E.J. and Friedrich, E.C. 1989. The Essential Oil of Poliomintha incana. Planta Medica 56(2): 224-226, 1990.
Herbicide IC50=1.5 uM Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp.
Insecticide not available Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8.
List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name Plant Part Low Parts Per Million High Parts Per Million Standard Deviation Reference
Acinos suaveolens Essential Oil not available 332200.0 -0.3 Jim Duke's personal files.
Acinos suaveolens Shoot not available 690400.0 5.2 Jim Duke's personal files.
Agastache pallidiflora Leaf not available not available not available Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980.
Agastache urticifolia Plant not available 1138.0 -0.5 Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980.
Agathosma betulina Leaf 1650.0 2750.0 -0.3 Duke, 1992 *
Barosma betulina Leaf 1650.0 2750.0 -0.3 Duke, 1992 *
Calamintha nepeta Plant not available 2760.0 -0.3 J. Ethnopharmacology, 39: 167.
Calamintha nepeta Leaf not available 3360.0 -0.2 Akgul, A., De Pooter, H.L., and De Buyck, L.F. 1991. The Essential Oils of Calamintha nepeta subsp. glandulosa and Ziziphora clinopodioides from Turkey. J. Ess. Oil Res., 3: 7-10.
Capsicum annuum Fruit not available not available not available Chemical Constituents of Oriental Herbs (3 diff. books)
Capsicum frutescens Fruit not available not available not available Duke, 1992 *
Dracocephalum thymiflora Plant not available 280.0 -0.6 Duke, 1992 *
Ephedra sinica Shoot not available 7.0 -0.3 Duke, 1992 *
Hedeoma drummondii Plant 5500.0 7240.0 0.2 Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980.
Hedeoma pulegioides Plant 3678.0 27600.0 2.4 Duke, 1992 *
Hedeoma pulegioides Leaf 17.0 50.0 -0.7 Duke, 1992 *
Hedeoma pulegioides Stem 0.5 3.8 not available Duke, 1992 *
Hedeoma pulegioides Essential Oil not available not available not available Duke, 1992 *
Hedeoma pulegioides Pollen Or Spore not available 823000.0 not available Duke, 1992 *
Lycopus virginicus Plant 10.0 24.0 -0.6 Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980.
Mentha aquatica Leaf 54.0 153.0 -0.7 Duke, 1992 *