Chemical CAFFEINE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Dr. Duke's Phytochemical and Ethnobotanical Databases

U.S. Department of Agriculture

Chemical ID

CAFFEINE

CAS Registry Number

58082

Ubiquitous

No

List of known dosages
Dosage	Reference
LD50=127-1,200 (orl mus)	Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006., Merck 11th Edition
LD50=192 (orl rat)
LD50=200 (orl rat)
LD50=224-246 (orl rbt)
LD50=247-355 (orl rat)	Merck 11th Edition
LDlo=192 (orl hmn)

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
Topoisomerase-II-Inhibitor	99 mM	Shin, C. G., Strayer, J. M., Wani, M., Snapka, R. M. 1990. Rapid Evaluation of Topoisomerase Inhibitors: Caffeine Inhibition of Topoisomerases in vivo. Teratogen Carcinogen Mutagen, 10: 41-52.
Vasodilator	not available	Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp.

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Guazuma ulmifolia	Leaf	not available	not available	not available	Duke, 1992 *
Ilex paraguariensis	Leaf	2000.0	20000.0	-0.4	Duke, 1992 *
Paullinia cupana	Plant	not available	25000.0	not available	Duke, 1992 *
Paullinia cupana	Seed	9100.0	76000.0	2.2	Duke, 1992 *
Paullinia yoko	Bark	not available	27300.0	not available	Duke, 1992 *
Paullinia yoko	Leaf	not available	not available	not available	Duke, 1992 *
Theobroma angustifolium	Petiole	80.0	82.0	-1.1	Duke, 1992 *
Theobroma angustifolium	Seed	35.0	57.0	-1.0	Duke, 1992 *
Theobroma angustifolium	Testa	38.0	52.0	-1.0	Duke, 1992 *
Theobroma bicolor	Fruit	158.0	184.0	not available	Duke, 1992 *
Theobroma bicolor	Petiole	72.0	138.0	-0.3	Duke, 1992 *
Theobroma bicolor	Seed	110.0	147.0	-1.0	Duke, 1992 *
Theobroma bicolor	Testa	192.0	235.0	-0.4	Duke, 1992 *
Theobroma cacao	Seed	500.0	12900.0	-0.5	Duke, 1992 *
Theobroma cacao	Testa	130.0	723.0	1.4	Duke, 1992 *
Theobroma cacao	Petiole	51.0	252.0	1.3	Duke, 1992 *
Turnera diffusa	Shoot	not available	not available	not available	Duke, 1992 *
Turnera diffusa	Leaf	not available	not available	not available	Duke, 1992 *