Chemical BERBERINE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

BERBERINE

Ubiquitous

List of known dosages
Dosage	Reference
LD50=100 mg/kg
LD50=24 mg/kg (ipr mus)
LD50=329 (orl mus)
LD50=10-20 (ivn dog)
LD50=27.5 mg/kg man
LD50=>1,000 mg/kg (orl rat)
LD50=8.2 mg/kg (ivn mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD50=26.4 mg/kg (ipr mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
LD50=13.2 mg/kg (scu mus)	Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
Lachrymatory	not available	Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
Larvicide	9 ppm	Duke, 1992 *
Leucocytogenic	not available	Duke, 1992 *
Lipase-Inhibitor	not available	Medline (post 1990 searches filed in my computer)
Lipoxygenase-Inhibitor	IC50=118 uM	Duke, 1992 *
Mutagenic	not available	Duke, 1992 *
Mycobactericide	MIC=25-50 ug/ml	Duke, 1992 *
Mydriatic	not available	Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
Myocardiodepressant	not available	Duke, 1992 *
Myorelaxant	not available	Duke, 1992 *
Pesticide	not available	Duke, 1992 *
Phototoxic	9 ppm	Duke, 1992 *
Plasmodicide	IC50=0.14-0.36 ug/ml	Duke, 1992 *
Prostaglandin-Synthesis-Inhibitor	25 mg/kg ivn rbt	Huang, C. G., Chu, Z. L., Yang, Z. M. 1991. Effect of Berberine on Synthesis of Platelet TXA2 and Plasma PGI2 in Rabbits. Chung-Kuo Yao Li Hsueh Pao, 12(6): 526-528.
Protisticide	IC50=0.14-0.36 ug/ml	Duke, 1992 *
Respiradepressant	not available	Martindale's 28th
RNA-Depressant	not available	Duke, 1992 *
RT-Inhibitor	not available	Duke, 1992 *
Sedative	not available	Duke, 1992 *
Stomachic	not available	Duke, 1992 *

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Adonis vernalis	Plant	not available	not available	not available	Duke, 1992 *
Andira inermis	Bark	not available	not available	not available	Duke, 1992 *
Argemone mexicana	Plant	not available	410.0	not available	Duke, 1992 *
Berberis vulgaris	Root	4000.0	64800.0	1.1	Duke, 1992 *
Berberis vulgaris	Bark	not available	45000.0	1.0	Jim Duke's personal files.
Berberis vulgaris	Root Bark	25000.0	80000.0	not available	Duke, 1992 *
Berberis vulgaris	Stem Bark	20000.0	25000.0	1.0	Jim Duke's personal files.
Berberis vulgaris	Flower	not available	6600.0	not available	Jim Duke's personal files.
Berberis vulgaris	Stem	1600.0	28900.0	not available	Jim Duke's personal files.
Berberis vulgaris	Leaf	not available	3000.0	1.0	Jim Duke's personal files.
Berberis vulgaris	Plant	not available	not available	not available	Jim Duke's personal files.
Caulophyllum thalictroides	Plant	not available	not available	not available	Jim Duke's personal files.
Chelidonium majus	Plant	not available	not available	not available	Duke, 1992 *
Coptis chinensis	Rhizome	40000.0	90000.0	0.9	Duke, 1992 *
Coptis japonica	Rhizome	40000.0	70000.0	-0.3	Duke, 1992 *
Coptis spp	Rhizome	40000.0	90000.0	0.9	Duke, 1992 *
Corydalis spp	Plant	not available	not available	not available	Duke, 1992 *
Eschscholzia californica	Shoot	not available	not available	not available	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Hydrastis canadensis	Root	1385.0	60000.0	0.9	Duke, 1992 *
Hydrastis canadensis	Plant	not available	not available	not available	Duke, 1992 *