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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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MDR-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
LAHADININE-A IC50=2.5 ug/ml Kam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
LYCACONITINE IC50=74 ug/ml Kim, D. K., Kwon, H. Y., Lee, K. R., Rhee, D. K., Zee, O. P. 1998. Isolation of a Multidrug Resistance Inhibitor From Aconitum pseudo-laeve var. erectum. Arch Pharm Research, 21: 344-347.
PLEIOCARPINE IC50=3.1 ug/ml Kam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
PUERARIN *
QUINIDINE IC50=1-12 uM *
QUINIDINE 100 uM Critchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
QUININE IC50=4-17 uM *
RESERPINE 2.5-10 uM *
TANGERETIN *
TAXACIN 10 ug/ml Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXACUSTIN 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXAGIFINE 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXAYUNTIN 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXCHININ-B 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXINE-II 1 ug/mL *
TAXININE 1 ug/mL *
TAXININE-A 1 ug/mL *
TAXININE-B 1-10 ug/ml *
TAXININE-M 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-A 1 ug/mL *
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Trifolium subterraneum 1 13, 500
Trigonella foenum-graecum Fenugreek; Greek Clover; Greek Hay; Bockshornklee (Ger.); Alholva (Sp.) 1 50
Ulex micranthus 1 0
Ulex sp 1 0
Vandasina retusa 1 7
Vicia faba Broadbean; Faba Bean; Habas 1 59.69999885559082
Vigna angularis Adzuki Bean 1 21.200000762939453
Vigna radiata Green Gram; Mungbean 1 43.599998474121094
Vigna subterranea Bambarra Groundnut; Groundbean 1 12
Vigna unguiculata Cowpea; Black-eyed Pea; Crowder Pea; Southern Pea 1 93.19999694824219
Vinca minor Periwinkle; Running-Myrtle 1 0
Zingiber officinale Ginger 1 0