An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
  1. Home
  2. Aldose-Reductase-Inhibitor

Aldose-Reductase-Inhibitor

Download these results as:
CSV
EXCEL
PDF
List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
REYNOUTRIN IC71=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
RHAMNETIN IC23=1 uM *
RHAMNETIN IC57=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
RHAMNOCITRIN 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
RHOIFOLIN IC32=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
ROSMARINIC-ACID *
RUTIN 100 uM *
RUTIN 4 ug/ml Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
SALBOSTATIN IC50=0.7 mM Vertesy, L., Fehlhaber, H., Schulz, a. 1994. The Trehalase Inhibitor Salbostatin, a Novel Metabolite from Streptomyces albus, ATCC21838. Angew Chem Int Ed Engl, 33(18): 1844-1846.
SALFREDIN-A-4 Matsumoto, K., et al. 1995. Salfredins, New Aldose Reductase Inhibitors Produced by Crucibulum sp. RF-3817. I. Fermentation, Isolation and Structures of Salfredins. J Antibiot, 48(6): 439-446.
SALFREDIN-C-2 Matsumoto, K., et al. 1995. Salfredins, New Aldose Reductase Inhibitors Produced by Crucibulum sp. RF-3817. I. Fermentation, Isolation and Structures of Salfredins. J Antibiot, 48(6): 439-446.
SALICYLIC-ACID 724.6 uM Toyomizu, M., Sugiyama, S., Jin, R. L., Nakatsu, T. 1993. Alpha-Glucosidase and Aldose Reductase Inhibitors: Constituents of Cashew, Anacardium occidentale, Nut Shell Liquids. Phytotherapy Research, 7(3): 252-254.
SALVIANOLIC-ACID-A 0.01 uM rat Du, G. H., Qiu, Y., Tian, Y. E., Zhang, J. T. 1995. Prevention of Galactose-Induced Cataractogenesis in Rats by Salvianolic Acid A. Yao Hsueh Hsueh Pao, 30(8): 561-566.
SAMBUNIGRIN 0.1 mM/l rat (weak activity) Fujita, T., Ohira, K., Miyatake, K., Nakano, Y., Nakayama, M. 1995. Inhibitory Effect of Perillosides A and C, Related Monoterpene Glucosides on Aldose Reductase and Their Structure-Activity Relationships. Chem Pharm Bull, 43(6): 920-926.
SANGGENONE-C 100 uM Yamaguchi, T., Sato, J., Mihashi, H., Nomura, T. 1991. Aldose Reductase Inhibitors Containing Benzopyrans for Treatment of Diseases Associated with Diabetes. Patent, Japan Kokai Tokkyo Koho-03 68,517. 9pp.
SAPPANCHALCONE 0.1 uM Morota, T., Takeda, H., Sasaki, H., Sato, S. 1990. Aldose Reductase Inhibitors Containing Phenol of Caesalpinia sappan. Patent, Japan Kokai Tokkyo Koho-02 264,718.
SCOPARONE 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
SCOPOLETIN IC50=6.2 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
SCUTELLAREIN IC56=10uM; IC10=1uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
SIDERITOFLAVONE *
Download these results as:
CSV
EXCEL
PDF
List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Teucrium cyprium 'Cyprus' Germander 5 1, 774
Teucrium divaricatum Hoary Divaricate Germander 5 117
Teucrium gnaphalodes Iberian Germander 5 15.5
Teucrium kotschyanum Stavros Kotschy's Germander 5 370
Teucrium micropodioides Small 'Cyprus' Germander 5 182
Teucrium montanum Mountain Germander 2 0
Teucrium oxylepis 4 16.96999990940094
Teucrium polium Iberian Golden Germander; Golden Germander 9 66
Teucrium pseudoscorodonia 4 1.4600000083446503
Teucrium salviastrum 4 3.159999966621399
Teucrium scordium Water Germander 4 0
Teucrium scorodonia Germander; Wood Germander 8 40, 005.860000014305
Teyleria koordersii 1 10
Theobroma bicolor Nicaraguan Cacao; Pataste 1 2, 020
Theobroma cacao Cacao 12 101
Theobroma speciosum Macambo 1 230
Thermopsis fabacea 1 0
Thermopsis sp 1 0
Thespesia populnea Indian tulip tree 3 79, 500
Thevetia peruviana Peruvian Yellow Oleander; Luckynut; Yellow Oleander; Oleandre Jaune (Fr.); Thevetie (Ger.); Loandro-Amarelo (Port.); Adelfa Amarilla (Sp.); Cabalonga (Sp.); Chirca (Sp.) 2 0