Ononis spinosa | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

Back to previous

Download a full report in PDF format

Common name(s)

Hauhechel (Ger.), Restharrow, Spiny Restharrow

How used

Medicinal

Data Views

Activities: 430

Chemicals w/Activities: 46

All Chemicals: 81

CSV Excel PDF

Exclude ubiquitous chemicals - View the list of ubiquitous chemicals

List of all chemical
Click on column headings to sort table by that column
# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
1	(-)-MAACKIAIN-3-O-GLUCOSIDE	Root	--	--	--	*
Antitumor *
5	24-METHYLENE-CYCLOARTANOL	Root	--	220.0	--	*
Antiinflammatory * Antinociceptive * Antirheumatic 2-5 mg/man * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Hypocholesterolemic *
0	5-DEOXYISOFLAVONE	Shoot	--	--	--	Blaschek, W., Hansel, R., Keller, K., Reichling, J., Rimpler, H., and Schneider, G. eds. 1998. Hager's Handbuch der Pharmazeutischen Praxis, Auflage Band 2 (A-K), 909 pp., (L-Z), 858 pp. Springer-Verlag, Berlin.
0	7-DEMETHOXY-7-D-GLUCOSYLOXY-HOMOPTEROCARPIN	Root	--	--	--	Blaschek, W., Hansel, R., Keller, K., Reichling, J., Rimpler, H., and Schneider, G. eds. 1998. Hager's Handbuch der Pharmazeutischen Praxis, Auflage Band 2 (A-K), 909 pp., (L-Z), 858 pp. Springer-Verlag, Berlin.
0	ALPHA-ONOCERIN	Shoot	--	500.0	--	Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.
0	ALPHA-ONOCERIN	Root	--	4100.0	--	*
2	ALPHA-SPINASTEROL	Root	--	180.0	--	Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.
Antiinflammatory >Phenylbutazone * Antipyretic *
36	ANETHOLE	Root	--	--	--	*
Allergenic * Antibacterial MBC=200 ug/ml * Antigenotoxic 40-400 mg/kg orl mus * Antihepatotic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiinflammatory * AntiNF-kB * Antioxidant * Antiradicular * Antisalmonella MIC=200 ug/ml * Antiseptic 200 ug/ml * Antispasmodic * AntiTNF * Antitumor * Antiyeast * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidicide * Carminative Merck 11th Edition Dermatitigenic * Digestive Michael Castleman 1991. The Healing Herbs. Rodale Press, Emmaus, PA 436 pp. Estrogenic Australian J. Med Herbalism, 7: 29. Expectorant Martindale's 29th Fungicide Wolf, R.B. Effects Of p-Methoxycinnamaldehyde From Star Anise And Related Cinnamic Acid Derivatives On Velvetleaf Germination. Journal of Natural Products, 49(1): 156-158, 1986. Gastrostimulant * Hepatotoxic 695 mg/kg orl mus/days Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Immunostimulant Economic & Medicinal Plant Research, 1: 124. Insecticide Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Irritant Rinzler, C. A. 1990. The Complete Book of Herbs, Spices and Condiments. Facts on File, New York. 199 pp. Lactagogue * Leucocytogenic Economic & Medicinal Plant Research, 1: 124. Mutagenic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Nephroprotective Toxicol Appl. Pharmacol. 1996. Pesticide * Secretogogue Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Secretolytic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Sweetener 13 x sucrose * Sympathomimetic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
101	APIGENIN	Shoot	--	--	--	Blaschek, W., Hansel, R., Keller, K., Reichling, J., Rimpler, H., and Schneider, G. eds. 1998. Hager's Handbuch der Pharmazeutischen Praxis, Auflage Band 2 (A-K), 909 pp., (L-Z), 858 pp. Springer-Verlag, Berlin.
11B-HSD-Inhibitor * AntiADD * Antiaflatoxin IC50=2.57 ppm * Antiaflatoxin IC50=9.52 uM * Antiaggregant * Antiaging * Antiallergic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiangiogenic 4 uM * Antiarrhythmic * Antibacterial Recio, M. C., Rios, J. L., and Villar, A., A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978-1988, Phytotherapy Research, 3(4), 1989, 117-125. Anticancer (Lung) * Anticomplementary * Antidermatitic Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp. Antiestrogenic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiherpetic 20-54 ug/ml * Antihistaminic IC50=10-35 uM * AntiHIV IC72=200 ug/ml * AntiHIV IC50=143 ug/ml * Antiinflammatory #NAME? * Antiinflammatory IC~65=1,000 uM * Antileukemic 20-50 uM * Antimelanomic 1-50 uM * Antimetastatic 1-50 uM * Antimutagenic ID50=0.55 ug/ml * Antimutagenic ID50=10-40 nM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antioxidant IC28.5=62.5 ug/ml * Antioxidant 1.5 x Vit. E * Antiperistaltic * Antiproliferant 1-50 uM * Antiproliferant IC50=155 uM * Antispasmodic EC50=1-5 uM * Antistress 10 mg/kg * Antithyroid Jim Duke's personal files. Antitumor 1-50 uM * Antitumor (Breast) 1-50 uM * Antitumor (Lung) * Antitumor (Skin) * Antiviral 20-54 ug/ml * Anxiolytic 10 mg/kg * Apoptotic 12-60 uM * Aromatase-Inhibitor IC65=1 uM/l Journal of Medicinal Food 2: 235.1999. Beta-Glucuronidase-Inhibitor IC50=~40 uM * Calcium-Antagonist? Biochimica & Biophysica Acta, 1115: 69, 1991. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Choleretic * CNS-Depressant * COX-1-Inhibitor IC65=1,000 uM * COX-2-Inhibitor IC50=<15 uM * COX-2-Inhibitor IC>65=1,000 uM * COX-2-Inhibitor <40 uM * Cyclooxygenase-Inhibitor * Cytochrome-P450-1A1-Inhibitor * Cytotoxic 1-50 uM * Cytotoxic IC50=9.5 uM * Cytotoxic IC88=10 ug/ml Planta Medica, 57: A113, 1991. Deiodinase-Inhibitor Jim Duke's personal files. Differentiator MIC=30 uM * Differentiator IC40=40 uM * Diuretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. DNA-Protective * Estrogenic 16% genistein * Estrogenic EC50=1 uM * Estrogenic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. HIF-1alpha-Inhibitor * Hyaluronidase-Inhibitor IC50+=50-250 uM * Hypotensive Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. ICAM-1-Inhibitor * IKK-Inhibitor * iNOS-Inhibitor IC50=<15 uM * Inotropic * Interleukin-6-Inhibitor * MAO-Inhibitor * MAPK-Inhibitor * Musculotropic Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Mutagenic * Myorelaxant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. NADH-Oxidase-Inhibitor * NF-kB-Inhibitor * NO-Synthase-Inhibitor 5-50 uM * Nodulation-Signal Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Ornithine-Decarboxylase-Inhibitor * P21-Inducer 10-70 uM * Pesticide * PKC-Inhibitor IC50=10 uM * Polyamine-Synthesis-Inhibitor * Progestational * Protein-Kinase-C-Inhibitor IC50=10-40 uM * PTK-Inhibitor 10-100 uM * Quinone-Reductase-Inducer 20 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216. Radioprotective * Sedative 30-100 mg/kg * Sunscreen * TNF-alpha-Inhibitor IC50=3.27 uM * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237. Topoisomerase-II-Inhibitor 50 ug/ml Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318. Topoisomerase-II-Inhibitor IC45=180 uM * Topoisomerase-II-Inhibitor IC28=18 uM * Uterotrophic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Vasodilator * VEGF-Inhibitor IC50=2-7 uM * Xanthine-Oxidase-Inhibitor 0.36 uM *
1	BIOCHANIN	Root	--	--	--	*
Estrogenic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.
32	BIOCHANIN-A	Root	0.8	7.0	-1.00	*
17-beta-hydroxysteroid dehydrogenase-Inhibitor 10.8 uM * 5-Alpha-Reductase-Inhibitor IC50=35 uM * 5-Alpha-Reductase-Inhibitor IC>80=100 uM * Alpha-Reductase-Inhibitor IC50=~35 uM * Antialcoholic * Anticarcinogenic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Anticephalagic * Antimutagenic Economic & Medicinal Plant Research, 6: 235. Antiproliferant * Antiprostatadenomic 8-27 ug/ml Medline (post 1990 searches filed in my computer) Antiprostatitic IC50=~35 uM * Antitumor (GI) * Antitumor (Lung) * Apoptotic >150 uM * Aromatase-Inhibitor IC45=1 uM/l Journal of Medicinal Food 2: 235.1999. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Chemopreventive Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. ER-Beta-Binder * Estrogen-Agonist 0.1-1 uM/l Journal of Medicinal Food 2: 139.1999. Estrogenic 0.1 uM * Estrogenic EC50=0.1-25 uM/l * Flatulent * Fungicide ED50=250-350 ug/ml Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Fungistat IC50=200 uM * Herbicide-Safener Chau (1985) in Purseglove et al. Acta Botanica Sinica, 2. Hypocholesterolemic * Hypolipidemic * Pesticide * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237. Topoisomerase-II-Inhibitor 50 ug/ml Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318. Uterotrophic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. VAM-Simulant Chau (1985) in Purseglove et al. Acta Botanica Sinica, 2.
0	BIOCHANIN-A-7-GLUCOSIDE	Root	--	--	--	Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp.
0	BIOCHANIN-A-7-GLUCOSIDE-6''-MALONATE	Root	--	--	--	Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp.
2	CAMPESTEROL	Root	--	22.0	-1.53	Blaschek, W., Hansel, R., Keller, K., Reichling, J., Rimpler, H., and Schneider, G. eds. 1998. Hager's Handbuch der Pharmazeutischen Praxis, Auflage Band 2 (A-K), 909 pp., (L-Z), 858 pp. Springer-Verlag, Berlin.
Antioxidant IC37=10 uM * Hypocholesterolemic Duke, J. A. Writeups or information summaries on approximately 2,000 economic plants, USDA, ARS, Beltsville, MD 20705.
19	CARVONE	Root	--	--	--	*
Allergenic * Antiacetylcholinesterase IC50=1.4-1.8 mM * Antiproliferative * Antiseptic 1.5 x phenol Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176) Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidistat * Carminative Yamamoto, A., Umemori, S., and Muranishi, S. 1993. Absorption Enhancement of Intrapulmonary Administered Insulin by Various Absorption Enhancers and Protease Inhibitors in Rats. J. Pharm. Pharmacol. 46: 14-18, 1994. CNS-Stimulant * FLavor FEMA 80-3,000 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Fungistat * Insecticide Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Motor-Depressant Buchbauer et al, e.g.Buchbauer et al,1993.Therapeutic properties of essential oils and fragrances. Chap.12 in Teranishi,R, Buttery,R.G and Sugisawa,H. Eds. Bioactive Volatile Compounds from Plants. ACS Symposium Series 525. Amer. Chem. Soc., Washington DC Nematicide MLC=1 mg/ml Shoyakugaku Zasshi, 44: 183. Perfumery Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide * Sedative Buchbauer et al, e.g.Buchbauer et al,1993.Therapeutic properties of essential oils and fragrances. Chap.12 in Teranishi,R, Buttery,R.G and Sugisawa,H. Eds. Bioactive Volatile Compounds from Plants. ACS Symposium Series 525. Amer. Chem. Soc., Washington DC Trichomonicide LD100=300 ug/ml * Vermicide *
1	CHOLESTEROL	Root	--	68.0	--	*
Antioxidant IC43=10 uM *
18	CINNAMIC-ACID	Root	--	--	--	Blaschek, W., Hansel, R., Keller, K., Reichling, J., Rimpler, H., and Schneider, G. eds. 1998. Hager's Handbuch der Pharmazeutischen Praxis, Auflage Band 2 (A-K), 909 pp., (L-Z), 858 pp. Springer-Verlag, Berlin.
Aldose-Reductase-Inhibitor 4 ug/ml (weak activity) Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110. Allergenic * Anesthetic * Antibacterial Martindale's 28th Antiinflammatory * Antimutagenic Economic & Medicinal Plant Research, 6: 235. Antispasmodic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Choleretic * Dermatitigenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. FLavor FEMA 4-40 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Fungicide * Herbicide * Laxative * Lipoxygenase-Inhibitor * Pesticide * Tyrosinase-Inhibitor ID50=700 uM * Vermifuge *
4	COSMOSIIN	Shoot	--	--	--	Blaschek, W., Hansel, R., Keller, K., Reichling, J., Rimpler, H., and Schneider, G. eds. 1998. Hager's Handbuch der Pharmazeutischen Praxis, Auflage Band 2 (A-K), 909 pp., (L-Z), 858 pp. Springer-Verlag, Berlin.
Aldose-Reductase-Inhibitor IC40=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888. Aldose-Reductase-Inhibitor IC99=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888. Antibacterial MIC=500 ug/ml Planta Medica, 57: A43, 1991. Candidicide MIC=500 ug/ml Planta Medica, 57: A43, 1991.
0	CYCLITE	Plant	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
7	CYCLOARTENOL	Root	--	780.0	--	*
Antibacterial * Antiinflammatory * Antirheumatic 2-5 mg/man * Antistaphylococcic * Hypocholesterolemic * Pesticide * Ubiquiot Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

Show all rows.

^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Ononis spinosa (Fabaceae)

Data Views