Hydnocarpus wightiana | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Hindi Chaulmoogra

How used

Medicinal

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Activities: 154

Chemicals w/Activities: 12

All Chemicals: 27

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
0	ALEPRESTIC-ACID	Seed	--	--	--	*
0	ALEPRIC-ACID	Seed	--	--	--	*
0	ALEPROLIC-ACID	Seed	--	--	--	*
0	ALEPRYLIC-ACID	Seed	--	--	--	*
101	APIGENIN	Seed	--	--	--	*
11B-HSD-Inhibitor * AntiADD * Antiaflatoxin IC50=9.52 uM * Antiaflatoxin IC50=2.57 ppm * Antiaggregant * Antiaging * Antiallergic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiangiogenic 4 uM * Antiarrhythmic * Antibacterial Recio, M. C., Rios, J. L., and Villar, A., A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978-1988, Phytotherapy Research, 3(4), 1989, 117-125. Anticancer (Lung) * Anticomplementary * Antidermatitic Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp. Antiestrogenic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiherpetic 20-54 ug/ml * Antihistaminic IC50=10-35 uM * AntiHIV IC50=143 ug/ml * AntiHIV IC72=200 ug/ml * Antiinflammatory #NAME? * Antiinflammatory IC~65=1,000 uM * Antileukemic 20-50 uM * Antimelanomic 1-50 uM * Antimetastatic 1-50 uM * Antimutagenic ID50=10-40 nM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antimutagenic ID50=0.55 ug/ml * Antioxidant 1.5 x Vit. E * Antioxidant IC28.5=62.5 ug/ml * Antiperistaltic * Antiproliferant 1-50 uM * Antiproliferant IC50=155 uM * Antispasmodic EC50=1-5 uM * Antistress 10 mg/kg * Antithyroid Jim Duke's personal files. Antitumor 1-50 uM * Antitumor (Breast) 1-50 uM * Antitumor (Lung) * Antitumor (Skin) * Antiviral 20-54 ug/ml * Anxiolytic 10 mg/kg * Apoptotic 12-60 uM * Aromatase-Inhibitor IC65=1 uM/l Journal of Medicinal Food 2: 235.1999. Beta-Glucuronidase-Inhibitor IC50=~40 uM * Calcium-Antagonist? Biochimica & Biophysica Acta, 1115: 69, 1991. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Choleretic * CNS-Depressant * COX-1-Inhibitor IC65=1,000 uM * COX-2-Inhibitor IC>65=1,000 uM * COX-2-Inhibitor <40 uM * COX-2-Inhibitor IC50=<15 uM * Cyclooxygenase-Inhibitor * Cytochrome-P450-1A1-Inhibitor * Cytotoxic IC88=10 ug/ml Planta Medica, 57: A113, 1991. Cytotoxic 1-50 uM * Cytotoxic IC50=9.5 uM * Deiodinase-Inhibitor Jim Duke's personal files. Differentiator MIC=30 uM * Differentiator IC40=40 uM * Diuretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. DNA-Protective * Estrogenic EC50=1 uM * Estrogenic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Estrogenic 16% genistein * HIF-1alpha-Inhibitor * Hyaluronidase-Inhibitor IC50+=50-250 uM * Hypotensive Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. ICAM-1-Inhibitor * IKK-Inhibitor * iNOS-Inhibitor IC50=<15 uM * Inotropic * Interleukin-6-Inhibitor * MAO-Inhibitor * MAPK-Inhibitor * Musculotropic Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Mutagenic * Myorelaxant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. NADH-Oxidase-Inhibitor * NF-kB-Inhibitor * NO-Synthase-Inhibitor 5-50 uM * Nodulation-Signal Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Ornithine-Decarboxylase-Inhibitor * P21-Inducer 10-70 uM * Pesticide * PKC-Inhibitor IC50=10 uM * Polyamine-Synthesis-Inhibitor * Progestational * Protein-Kinase-C-Inhibitor IC50=10-40 uM * PTK-Inhibitor 10-100 uM * Quinone-Reductase-Inducer 20 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216. Radioprotective * Sedative 30-100 mg/kg * Sunscreen * TNF-alpha-Inhibitor IC50=3.27 uM * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237. Topoisomerase-II-Inhibitor IC45=180 uM * Topoisomerase-II-Inhibitor IC28=18 uM * Topoisomerase-II-Inhibitor 50 ug/ml Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318. Uterotrophic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Vasodilator * VEGF-Inhibitor IC50=2-7 uM * Xanthine-Oxidase-Inhibitor 0.36 uM *
0	ARACHNIC-ACID	Seed	--	--	--	*
0	ASH	Seed	--	38300.0	-0.29	*
22	BETULINIC-ACID	Leaf	--	48.8	-0.98	Jim Duke's personal files.
Anthelmintic * Antibacterial * Anticancer Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Anticarcinomic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiedemic * AntiHIV EC50=2.0 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. AntiHIV 14.8 uM * AntiHIV IC50=6.5 ug/ml * Antiinflammatory Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas. Planta Medica, 61: 9. Antileukemic Antimalarial IC50=19-26 ug/ml * Antimelanomic New York Times, 3/28/95. Antinociceptive * Antiplasmodial IC50=19-26 ug/ml * Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral 14.8 uM * Apoptotic * Cytotoxic 16.4 uM * Cytotoxic 50-100 ppm Biosyn. Prod. Cancer Chemotherapy (Petit et al) Phospholipase-A2-Inhibitor * Prostaglandin-Synthesis-Inhibitor 200 ug/ml Dunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497. Prostaglandin-Synthesis-Inhibitor IC50=101 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.
22	BETULINIC-ACID	Seed	--	--	--	Jim Duke's personal files.
Anthelmintic * Antibacterial * Anticancer Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Anticarcinomic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiedemic * AntiHIV EC50=2.0 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. AntiHIV 14.8 uM * AntiHIV IC50=6.5 ug/ml * Antiinflammatory Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas. Planta Medica, 61: 9. Antileukemic Antimalarial IC50=19-26 ug/ml * Antimelanomic New York Times, 3/28/95. Antinociceptive * Antiplasmodial IC50=19-26 ug/ml * Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral 14.8 uM * Apoptotic * Cytotoxic 16.4 uM * Cytotoxic 50-100 ppm Biosyn. Prod. Cancer Chemotherapy (Petit et al) Phospholipase-A2-Inhibitor * Prostaglandin-Synthesis-Inhibitor 200 ug/ml Dunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497. Prostaglandin-Synthesis-Inhibitor IC50=101 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.
22	BETULINIC-ACID	Stem Bark	--	66.6	-0.40	Jim Duke's personal files.
Anthelmintic * Antibacterial * Anticancer Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Anticarcinomic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiedemic * AntiHIV EC50=2.0 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. AntiHIV 14.8 uM * AntiHIV IC50=6.5 ug/ml * Antiinflammatory Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas. Planta Medica, 61: 9. Antileukemic Antimalarial IC50=19-26 ug/ml * Antimelanomic New York Times, 3/28/95. Antinociceptive * Antiplasmodial IC50=19-26 ug/ml * Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral 14.8 uM * Apoptotic * Cytotoxic 16.4 uM * Cytotoxic 50-100 ppm Biosyn. Prod. Cancer Chemotherapy (Petit et al) Phospholipase-A2-Inhibitor * Prostaglandin-Synthesis-Inhibitor 200 ug/ml Dunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497. Prostaglandin-Synthesis-Inhibitor IC50=101 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.
3	CHAULMOOGRIC-ACID	Seed	--	170775.0	1.00	*
Antibacterial MIC=32-64 ug/ml Martindale's 28th Antilepric Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Antisarcoidosic Merck 11th Edition
7	CHRYSOERIOL	Seed	--	--	--	*
Aldose-Reductase-Inhibitor IC31=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888. Anticomplementary * Antimutagenic Economic & Medicinal Plant Research, 6: 235. Antioxidant * Antirhinoviral Economic & Medicinal Plant Research, 5: 197. Antiviral Economic & Medicinal Plant Research, 5: 197. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
0	DIHYDROCHAULMOOGRIC-ACID	Seed	--	--	--	*
0	DIHYDROHYDNOCARPIC-ACID	Seed	--	--	--	*
0	FAT	Seed	--	632500.0	1.93	*
0	GORLIC-ACID	Seed	--	77165.0	-1.00	*
3	HYDNOCARPIC-ACID	Seed	--	308000.0	1.00	*
Antibacterial Merck 11th Edition Antilepric * Pesticide *
0	HYDNOCARPIN	Fruit	--	--	--	*
0	ISOGALEIC-ACID	Seed	--	--	--	*
1	LEUCOPELARGONIDIN	Fruit	--	--	--	*
Antineoplastic *

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Hydnocarpus wightiana (Flacourtiaceae)

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