Curcuma xanthorrhiza | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Javan Turmeric, Temu Lawak

How used

Medicinal

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Activities: 167

Chemicals w/Activities: 10

All Chemicals: 27

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
0	ALNUSTONE	Rhizome	--	--	--	*
11	ALPHA-PHELLANDRENE	Rhizome	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Antibacterial Wright,C.W.(Ed)2002.Medicinal&Aromatic Plants-Industrial Profiles.Artemisia.344pp.Maffei,M.(Ed)2002.Vetiveria.The Genus Vetiveria.Taylor&Francis.NY,NY.191pp.Southwell,I.,Lowe,R.(Eds)1999.Tea Tree.The Genus Melaleuca.Harwood Acad.Pub.Amsterdam,Netherlands. Antistaphylococcic Wright,C.W.(Ed)2002.Medicinal&Aromatic Plants-Industrial Profiles.Artemisia.344pp.Maffei,M.(Ed)2002.Vetiveria.The Genus Vetiveria.Taylor&Francis.NY,NY.191pp.Southwell,I.,Lowe,R.(Eds)1999.Tea Tree.The Genus Melaleuca.Harwood Acad.Pub.Amsterdam,Netherlands. Dermal Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Emetic * FLavor FEMA 10-130 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Fungicide Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Insectiphile Pakistan Encyclopedia Planta Medica. 1986. Irritant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Laxative * Perfumery Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide *
3	AR-CURCUMENE	Rhizome	--	--	--	*
Antirhinoviral IC50=1,750? Denyer, C.V., Jackson, P., Loakes, D.M., Ellis, M.R., and Yound, D.A.B. Isolation of Antirhinoviral Sesquiterpenes From Ginger (Zingiber officinale). Journal of Natural Products, 57(5): 658-662, 1994. Antiulcer IC45=100 mg/kg Yamahara, J., et al. Stomachic principles in ginger. II. Pungent and anti-ulcer effects of low polar constituents isolated from ginger, the dried rhizoma of... Yakugaku Zasshi 112: 645-655 (1992). Antiviral IC50=1,750? Denyer, C.V., Jackson, P., Loakes, D.M., Ellis, M.R., and Yound, D.A.B. Isolation of Antirhinoviral Sesquiterpenes From Ginger (Zingiber officinale). Journal of Natural Products, 57(5): 658-662, 1994.
0	ATLANTONE	Rhizome	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
0	BETA-CURCUMENE	Rhizome	--	--	--	*
0	BIS-(P-HYDROXY-CINNAMOYL)-METHANE	Rhizome	--	--	--	Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp.
5	BIS-DESMETHOXYCURCUMIN	Rhizome	--	--	--	Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp.
Antialzheimeran 0.5-10 ug/ml * Antiamyloid-Beta 0.5-10 ug/ml * Antiangiogenic * Anticholeretic HerbalGram No. 17. Antiinflammatory Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp.
35	BORNEOL	Rhizome	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
(-)-Chronotropic 29 ug/ml Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. (-)-Inotropic 29 ug/ml Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Allelochemic * Analgesic * Antiacetylcholine Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antibacterial MIC=125-250 ug/ml * Antibronchitic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiescherichic MIC=125 ug/ml * Antifeedant * Antiinflammatory * Antiotitic * Antipyretic * Antisalmonella MIC=125 ug/ml * Antispasmodic ED50=0.008 mg/ml * Antistaphylococcic MIC=250 ug/ml * Antiyeast MIC=250 ug/ml * Candidicide MIC=250 ug/ml * Choleretic * CNS-Stimulant List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979. CNS-Toxic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. FLavor FEMA<1 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Fungicide * Hepatoprotective * Herbicide IC50=470 uM Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Herbicide IC50=470 mM Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Inhalant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Insect-Repellent * Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Irritant Rinzler, C. A. 1990. The Complete Book of Herbs, Spices and Condiments. Facts on File, New York. 199 pp. Myorelaxant Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Nematicide MLC=1 mg/ml Shoyakugaku Zasshi, 44: 183. Perfumery Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide * Sedative Medline (post 1990 searches filed in my computer) Tranquilizer *
4	CALCIUM-OXALATE	Rhizome	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Emetic * Inflammatory * Laxative * Lithogenic *
135	CURCUMIN	Rhizome	100.0	10000.0	-0.51	*
12-Lipoxygenase-Inhibitor * 5-Alpha-Reductase-Inhibitor * 5-HETE-Inhibitor IC50=3-10 uM * 5-Lipoxygenase-Inhibitor * 8-HETE-Inhibitor IC40=3 uM * Antiadenomacarcinogenic 50-200 mg/kg ipr rat * Antiaflatoxin IC50=81 uM * Antiaggregant * Antialzheimeran 0.5-10 ug/ml * Antiamyloid-Beta 0.5-10 ug/ml * Antiangiogenic * Antiarachidonate * Antiarthritic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiasthmatic * Antiatherosclerotic 0.4-20 mg/kg/day * Antibacterial Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Antibronchitic * Anticancer * Anticancer (Breast) * Anticancer (Colon) * Anticancer (Duodenum) * Anticancer (Mammary) 50-200 mg/kg ipr rat * Anticancer (Skin) * Anticancer (Stomach) * Anticarcinogenic * Anticataract 75 mg/kg orl rat * Anticholecystosic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Anticolitic * Anticollagenic * AntiCrohn's * AntiEBV IC50=5.4 uM * Antieczemic Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Antiedemic ED50=100.2 mg/kg orl mus (cf 78 for cortisone) * Antiedemic ED50=48 mg/kg orl rat (cf 45 for cortisone) * Antiedemic ED50=48 mg/kg orl rat (cf 48 for phenylbutazone) * Antieicosanoid * Antihepatotic * AntiHIV IC50=40 uM * Antiinflammatory 1 uM * Antiinflammatory 1,200 mg/man/day * Antiintegrase 40-150 uM * Antiischemic * Antileishmanic IC50=7.8 ug/ml * Antileukemic * Antileukotriene 170 mg/kg orl rat * Antilipoperoxidant * Antilithic 0.5% diet * Antilymphomic 4 ug/ml Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Antilymphomic 0.4 mg/ml Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Antimelanomic 200 nM/kg orl mus * Antimetastatic 200 nM/kg orl mus * Antimutagenic * Antinitrosaminic * Antioxidant 1/3 BHA * Antioxidant IC50=500 uM * Antipapillomic * Antiperoxidant * Antiproliferant IC50=13 uM * Antiprostaglandin 8.8 uM * Antipsoriatic * Antispasmodic =ICMR(Indian Council of Medical Research).1976.Medicinal Plants of India.Vol.1.Indian Council of Med. Res.Cambridge Printing Works, New Delhi.487 pp;ICMR.1987.Medicinal Plants of India.Vol.2.Indian Council of Med. Res.Cambr. Printing Works,New Delhi.600pp Antithrombotic * Antithromboxane * Antitumor * Antitumor (Colon) * Antitumor (Liver) 10 uM * Antitumor-Promoter IC91=10 uM * Antiulcer orl rat * Antiviral IC50=5.4 uM * Apoptotic 30-90 uM * Apoptotic 150-2,000 ppm (diet) orl rat * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardiodepressant =ICMR(Indian Council of Medical Research).1976.Medicinal Plants of India.Vol.1.Indian Council of Med. Res.Cambridge Printing Works, New Delhi.487 pp;ICMR.1987.Medicinal Plants of India.Vol.2.Indian Council of Med. Res.Cambr. Printing Works,New Delhi.600pp Chelator IC50=500 uM * Chelator Iron * Chemopreventive * Cholagogue * Choleretic HerbalGram No. 24, page 37. COX-2-Inhibitor 10-20 uM * Cyclooxygenase-Inhibitor * Cytochrome-P450-Inhibitor Pizzorno, J. 1998. Total Wellness. Prima Health, a division of Prima. Cytotoxic 0.4-4 mg/ml Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Cytotoxic IC50=25 uM * Cytotoxic IC50=1 ug/ml * Deodorant Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Detoxicant * DNA-Protective * Dye Merck 11th Edition Expectorant 100 uM * Fibrinolytic * Fungicide * Glutathionigenic 80 mg/kg igs rat * Hepatoprotective 30 ppm * Hepatoprotective 30 mg/kg/day * Hypocholesterolemic 0.15% diet 7 wks * Hypolipidemic 0.15% diet 7 wks * Hypotensive * IkappaB-alpha-Phosphorylation-Inhibitor * IKB-kinase-Inhibitor * IKK-Inhibitor * Immunostimulant 40 mg/kg/5 wk orl rat * Lipase-Inducer * Litholytic 0.5% diet * Maltase-Promoter * MDR-Inhibitor 1-55 uM * Metal-Chelator McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. MMP-9-Inhibitor 10 uM * Mucogenic 100 uM * Nematicide * Neuroprotective 80 mg/kg igs rat * NF-kB-Inhibitor * NO-Inhibitor * NO-Scavenger * Ornithine-Decarboxylase-Inhibitor ED=~150 mg/kg * P450-Inhibitor IC50=2-14 ug/ml * Pesticide * PGE2-Inhibitor IC42=3 uM * Phototoxic Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Plasmodicide * Prostaglandin-Synthesis-Inhibitor 0.2% diet rat Rao, C. V., Rivenson, A., Simi, B., Reddy, B. S. 1995. Chemoprevention of Colon Carcinogenesis by Dietary Curcumin, a Naturally Occurring Plant Phenolic Compound. Cancer Research, 55(2): 259-266. Protease-Inhibitor IC50=11-250 uM * Protein-Kinase-C-Inhibitor IC69=15 uM * Protein-Kinase-C-Inhibitor IC50=15 uM * Protein-Kinase-Inhibitor * PTK-Inhibitor 5-100 uM * Pulmonoprotective 200 mg/kg/7 d * Quinone-Reductase-Inducer 3.4 uM Singletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043. Radioprotective * Sortase-A-Inhibitor IC50=13-14 ug/ml * Sucrase-Promoter * TNF-Inhibitor * Topoisomerase-I-Inhibitor * Topoisomerase-II-Inhibitor * Ulcerogenic orl rat * VEGF-Inhibitor *
9	CURCUMINOIDS	Rhizome	8000.0	20000.0	-1.00	*
Anticancer Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Antiinflammatory Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Antileukotriene Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Antimitotic Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Antiprostaglandin Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp. Antitumor Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Cholagogue Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Cytotoxic Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Ulcerogenic? Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp.
0	D-CAMPHOR	Rhizome	500.0	2950.0	1.35	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
0	DESMETHOXYCURCUMIN	Rhizome	100.0	10000.0	-0.27	*
0	DESMETHOXYCURCUMIN	Plant	100.0	10000.0	--	*
0	EO	Rhizome	30000.0	295000.0	3.67	*
0	FURANODIENE	Rhizome	--	--	--	*
0	FURANODIENONE	Rhizome	--	--	--	*
0	GERMACRENE	Rhizome	--	--	--	*
0	ISOFURANOGERMACRENE	Rhizome	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
0	L-CYCLOISOPRENEMYRCENE	Rhizome	42500.0	250750.0	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Curcuma xanthorrhiza (Zingiberaceae)

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