Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture

Chemical THEOBROMINE

Chemical ID
THEOBROMINE
Ubiquitous
No
List of known dosages
Dosage Reference
LD50=200 (orl cat)
LD50=789 mg/kg (ipr mus) Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.
LD50=1,356 mg/kg (orl mus) Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.
LD50=950 mg/kg (orl rat) Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Dosage Reference
Anorexic Martindale's 28th
Antiasthmatic 10 mg/kg/orl/man Martindale's 29th
Anticellulitic *
Arteriodilator *
Bronchodilator Merck 11th Edition
cAMP-Inhibitor IC50=0.06 mg/ml Schussler, M., Fricke, U., Nikolov, N., and Holzl, J. 1991. Comparison of the Flavonoids Occurring in Crataegus species and Inhibition of 3',5'-Cyclic Adenosine Monophosphate Phosphodiesterase. Plant Medica 57: Suppl Issue 2. p.A-133.
cAMP-Phosphodiesterase-Inhibitor Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Cardiotonic Merck 11th Edition
cGMP-Phosphodiesterase-Inhibitor Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
CNS-Stimulant *
Diuretic 300-600 mg/man/day Martindale's 28th
Emetic Martindale's 28th
Fetotoxic 100 mg/kg *
Herbicide IC41=100 ppm Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.
Myocardiotonic *
Myorelaxant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Myostimulant Martindale's 29th
Pesticide *
Stimulant *
Teratogenic 100 mg/kg *
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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name Plant Part Low Parts Per Million High Parts Per Million Standard Deviation Reference
Camellia japonica Flower *
Camellia japonica Leaf Wealth of India.
Camellia sinensis Leaf 500.0 1100.0 -1.0 *
Camellia sinensis Pericarp *
Camellia sinensis Flower *
Camellia sinensis Seed Coat *
Camellia sinensis Seed *
Camellia sinensis Stem *
Camellia sinensis Anther *
Coffea arabica Leaf *
Coffea arabica Seed 18.0 20.0 -0.5 *
Cola acuminata Seed 1000.0 -0.4 *
Ilex paraguariensis Leaf 960.0 5000.0 1.0 *
Paullinia cupana Seed 200.0 400.0 -0.5 *
Theobroma angustifolium Petiole 30.0 32.0 -1.2 *
Theobroma angustifolium Seed 330.0 368.0 -0.5 *
Theobroma angustifolium Testa 294.0 332.0 -1.4 *
Theobroma bicolor Petiole 117.0 129.0 0.0 *
Theobroma bicolor Seed 1139.0 1710.0 -0.4 *
Theobroma bicolor Testa 8787.0 9158.0 0.3 *