Chemical GENISTEIN | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

GENISTEIN

Ubiquitous

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
NADH-Ubiquinone-Oxidoreductase-Inhibitor	not available	Duke, 1992 *
Natriuretic	not available	Duke, 1992 *
Ornithine-Decarboxylase-Inhibitor	not available	Duke, 1992 *
Peroxidase-Inhibitor	not available	Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Pesticide	not available	Duke, 1992 *
Phytoalexin	not available	Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.
Pituitary-sensitizer	not available	Medline (post 1990 searches filed in my computer)
PTK-Inhibitor	10-100 uM	Duke, 1992 *
Quinone-Reductase-Inducer	IC50=4.6 ug/ml	Duke, 1992 *
Topoisomerase-I-Inhibitor	IC50=250 ppm	Duke, 1992 *
Topoisomerase-I-Inhibitor	1-10 ug/ml	Okura, A., Arakawa, H., Oka, H., Yoshinari, T., Monden, Y. 1988. Effect of Genistein on Topoisomerase Activity and on the Growth of [VAL 12]HA-RAS-Transformed NIH 3T3 Cells. Biochem Biophys Res Commun, 157: 183-189.
Topoisomerase-II-Inhibitor	2-7.5 ug/ml	Duke, 1992 *
Topoisomerase-II-Inhibitor	IC50=30 ug/ml	Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225.
Topoisomerase-II-Inhibitor	20 uM	Markovits, J., et al. 1989. Inhibitory Effects of the Tyrosine Kinase Inhibitor Genistein on Mammalian DNA Topoisomerase II. Cancer Research, 49: 5111-5117.
Topoisomerase-II-Inhibitor	IC50=1-150 uM	Duke, 1992 *
Topoisomerase-II-Poison	not available	Journal of Medicinal Food 2: 167.1999.
Trypanosomastat	not available	Medline (post 1990 searches filed in my computer)
Tyrosine-Kinase-Inhibitor	not available	Duke, 1992 *
Uterotrophic	ED50=0.5 mg/kg	Duke, 1992 *
Uterotrophic	EC50=0.1-25 uM/l	Duke, 1992 *

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Adenocarpus decorticans	Leaf	not available	not available	not available	Duke, 1992 *
Adenocarpus foliolosus	Leaf	not available	not available	not available	Duke, 1992 *
Albizia procera	Bark	not available	not available	not available	Duke, 1992 *
Amphicarpaea bracteata	Leaf Diffusate	not available	5.0	-0.6	Duke, 1992 *
Amphicarpaea edgworthii	Leaf Diffusate	not available	11.0	0.1	Duke, 1992 *
Apios americana	Leaf Diffusate	6.0	12.0	0.2	Duke, 1992 *
Argyrocytisus battandieri	Leaf	not available	not available	not available	Duke, 1992 *
Baptisia sp	Leaf	not available	not available	not available	Duke, 1992 *
Baptisia tinctoria	Leaf	not available	not available	not available	Duke, 1992 *
Bowdichia nitida	Wood	not available	not available	not available	Duke, 1992 *
Cajanus cajan	Root	not available	not available	not available	Duke, 1992 *
Cajanus scarabaeoides	Leaf Diffusate	not available	3.0	-0.8	Duke, 1992 *
Calicotome spinosa	Leaf	not available	not available	not available	Duke, 1992 *
Calicotome villosa	Leaf	not available	not available	not available	Duke, 1992 *
Calopogonium caeruleum	Leaf Diffusate	not available	not available	not available	Duke, 1992 *
Camptosema sp	Leaf Diffusate	not available	12.0	0.2	Duke, 1992 *
Canavalia ensiformis	Leaf Diffusate	not available	6.0	-0.5	Duke, 1992 *
Canavalia eurycarpa	Leaf Diffusate	not available	5.0	-0.6	Duke, 1992 *
Canavalia galeata	Leaf Diffusate	not available	not available	not available	Duke, 1992 *
Canavalia gladiata	Leaf Diffusate	not available	not available	not available	Duke, 1992 *