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Chemical CURCUMIN

Chemical ID

CURCUMIN

Ubiquitous

No

List of known dosages
Dosage	Reference
LDlo=>2,000 mg/kg (orl mus)	Martindale's 28th
ADI=100 ug/kg	Martindale's 29th
TD=>5,000 mg/kg (orl rat)
LDlo=>1,800 mg/kg (orl rat)

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Sort descending	Dosage	Reference
Protease-Inhibitor	IC50=11-250 uM	Duke, 1992 *
Protein-Kinase-C-Inhibitor	IC69=15 uM	Duke, 1992 *
Protein-Kinase-C-Inhibitor	IC50=15 uM	Duke, 1992 *
Protein-Kinase-Inhibitor	not available	Duke, 1992 *
PTK-Inhibitor	5-100 uM	Duke, 1992 *
Pulmonoprotective	200 mg/kg/7 d	Duke, 1992 *
Quinone-Reductase-Inducer	3.4 uM	Singletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043.
Radioprotective	not available	Duke, 1992 *
Sortase-A-Inhibitor	IC50=13-14 ug/ml	Duke, 1992 *
Sucrase-Promoter	not available	Duke, 1992 *
TNF-Inhibitor	not available	Duke, 1992 *
Topoisomerase-I-Inhibitor	not available	Duke, 1992 *
Topoisomerase-II-Inhibitor	not available	Duke, 1992 *
Ulcerogenic	orl rat	Duke, 1992 *
VEGF-Inhibitor	not available	Duke, 1992 *

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