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Chemical BERBERASTINE

Chemical ID
BERBERASTINE
Ubiquitous
No
List of known dosages
Dosage
LD50=10-20 (ivn dog)
LD50=8.2 mg/kg (ivn mus)
LD50=100 mg/kg
LD50=24 mg/kg (ipr mus)
LD50=26.4 mg/kg (ipr mus)
LD50=27.5 mg/kg man
LD50=329 (orl mus)
LD50=13.2 mg/kg (scu mus)
LD50=>1,000 mg/kg (orl rat)
List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Dosage Reference
Lipoxygenase-Inhibitor IC50=118 uM Duke, 1992 *
Mutagenic not available Duke, 1992 *
Mycobactericide MIC=25-50 ug/ml Duke, 1992 *
Mydriatic not available Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill
Livinston, Edinburgh.
Myocardiodepressant not available Duke, 1992 *
Myorelaxant not available Duke, 1992 *
Pesticide not available Duke, 1992 *
Phototoxic 9 ppm Duke, 1992 *
Plasmodicide IC50=0.14-0.36 ug/ml Duke, 1992 *
Prostaglandin-Synthesis-Inhibitor 25 mg/kg ivn rbt Huang, C. G., Chu, Z. L., Yang, Z. M. 1991. Effect of Berberine on Synthesis of Platelet TXA2 and Plasma PGI2 in Rabbits. Chung-Kuo Yao Li Hsueh Pao, 12(6): 526-528.
Protisticide IC50=0.14-0.36 ug/ml Duke, 1992 *
Respiradepressant not available Martindale's 28th
RNA-Depressant not available Duke, 1992 *
RT-Inhibitor not available Duke, 1992 *
Sedative not available Duke, 1992 *
Stomachic not available Duke, 1992 *
Topoisomerase-II-Inhibitor 2.5 uM Kobayashi, Y, Yamashita, Y., Fujii, N., Takaboshi, K., Kawakami, T., Kawamura, M., Mizukami, T., Nakano, H. 1995. Inhibitors of DNA Topoisomerase I and II Isolated From the Coptis Rhizomes. Planta Medica, 61: 414-418.
Trichomonicide not available Martindale's 29th
Trypanocide not available Duke, 1992 *
Uterocontractant not available Duke, 1992 *
List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name Plant Part Low Parts Per Million High Parts Per Million Standard Deviation Reference
Coptis spp Rhizome not available not available not available Duke, 1992 *
Hydrastis canadensis Rhizome 20000.0 30000.0 not available Duke, 1992 *
Hydrastis canadensis Plant not available not available not available Duke, 1992 *
Xanthorhiza simplicissima Plant not available not available not available Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.