Chemical ID
BERBERASTINE
Ubiquitous
No
Dosage |
---|
LD50=10-20 (ivn dog) |
LD50=8.2 mg/kg (ivn mus) |
LD50=100 mg/kg |
LD50=24 mg/kg (ipr mus) |
LD50=26.4 mg/kg (ipr mus) |
LD50=27.5 mg/kg man |
LD50=329 (orl mus) |
LD50=13.2 mg/kg (scu mus) |
LD50=>1,000 mg/kg (orl rat) |
Activity | Dosage | Reference |
---|---|---|
Lipoxygenase-Inhibitor | IC50=118 uM | Duke, 1992 * |
Mutagenic | not available | Duke, 1992 * |
Mycobactericide | MIC=25-50 ug/ml | Duke, 1992 * |
Mydriatic | not available | Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. |
Myocardiodepressant | not available | Duke, 1992 * |
Myorelaxant | not available | Duke, 1992 * |
Pesticide | not available | Duke, 1992 * |
Phototoxic | 9 ppm | Duke, 1992 * |
Plasmodicide | IC50=0.14-0.36 ug/ml | Duke, 1992 * |
Prostaglandin-Synthesis-Inhibitor | 25 mg/kg ivn rbt | Huang, C. G., Chu, Z. L., Yang, Z. M. 1991. Effect of Berberine on Synthesis of Platelet TXA2 and Plasma PGI2 in Rabbits. Chung-Kuo Yao Li Hsueh Pao, 12(6): 526-528. |
Protisticide | IC50=0.14-0.36 ug/ml | Duke, 1992 * |
Respiradepressant | not available | Martindale's 28th |
RNA-Depressant | not available | Duke, 1992 * |
RT-Inhibitor | not available | Duke, 1992 * |
Sedative | not available | Duke, 1992 * |
Stomachic | not available | Duke, 1992 * |
Topoisomerase-II-Inhibitor | 2.5 uM | Kobayashi, Y, Yamashita, Y., Fujii, N., Takaboshi, K., Kawakami, T., Kawamura, M., Mizukami, T., Nakano, H. 1995. Inhibitors of DNA Topoisomerase I and II Isolated From the Coptis Rhizomes. Planta Medica, 61: 414-418. |
Trichomonicide | not available | Martindale's 29th |
Trypanocide | not available | Duke, 1992 * |
Uterocontractant | not available | Duke, 1992 * |
Plant Name | Plant Part | Low Parts Per Million | High Parts Per Million | Standard Deviation | Reference |
---|---|---|---|---|---|
Coptis spp | Rhizome | not available | not available | not available | Duke, 1992 * |
Hydrastis canadensis | Rhizome | 20000.0 | 30000.0 | not available | Duke, 1992 * |
Hydrastis canadensis | Plant | not available | not available | not available | Duke, 1992 * |
Xanthorhiza simplicissima | Plant | not available | not available | not available | Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. |