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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Topoisomerase-II-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
SERPENTINE 50 uM Dassonneville, L., et al. 1999. Stimulation of Topoisomerase II-Mediated DNA Cleavage by Three DNA-Intercalating Plant Alkaloids: Cyrptolepine, Matadine, and Serpentine. Biochemistry, 38: 7719-7726.
SHERMILAMINE-B 75 uM Schmitz, F. J., et al. 1991. Cytotoxic Aromatic Alkaloids From the Ascidian Amphicarpa meridiana and Leptoclinides sp.: Meridine and 11-hydroxyascididemin. J Org Chem, 56: 804-808.
SHERMILAMINE-B IC90=118 uM McDonald, L. A., et al . 1994. Inhibition of Topoisomerase II Catalytic Activity by Pyridoacridine Alkaloids From a Cystodytes sp. ascidian: A Mechanism for the Apparent Intercalator-Induced Inhibition of Topoisomerase II. J Med Chem, 37: 3819-3827.
SHERMILAMINE-C IC90=138 uM McDonald, L. A., et al . 1994. Inhibition of Topoisomerase II Catalytic Activity by Pyridoacridine Alkaloids From a Cystodytes sp. ascidian: A Mechanism for the Apparent Intercalator-Induced Inhibition of Topoisomerase II. J Med Chem, 37: 3819-3827.
STAUROSPORINE 50 nM Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318.
STAUROSPORINE IC50=1 uM Lassota, P., Singh, G., Kramer, R. 1996. Mechanism of Topoisomerase II Inhibition by Staurosporine and Other Protein Kinase Inhibitors. J Biol Chem, 271: 26418-26423.
STRICTININ IC100=0.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
TENIPOSIDE 1-20 uM *
TERCHEBIN IC100=0.2 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
TERPENTECIN 100 uM *
VESCALAGIN IC100=0.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
VESCALAGIN-CARBOXYLIC-ACID IC100=0.2 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
VIRENAMIDE-A IC50=2.5 ug/ml Carroll, A. R., Feng, Y. J., Bowden, B. F., Coll, J. C. 1996. Studies of Australian Ascidians. 5. Virenamides A-C, New Cytotoxic Linear Peptides From the Colonial Didemnid Ascidian Diplosoma Virens. J Org Chem, 61: 4059-4061.
WAKAYIN 250 uM Copp, B. R., Ireland, C. M., Barrows, L. R. 1991. Wakayin: A Novel Cytotoxic Pyrroloiminoquinone Alkaloid From the Ascidian Clavelina Species. J Org Chem, 56: 4596-4597.
WOODFORDIN-C 2.5 ug/ml Kuramochi-Motegi, A., et al. 1992. Woodfruticosin (Woodfordin C), a New Inhibitor of DNA Topoisomerase II. Experimental Antitumor Activity. Biochem Pharmacol, 44: 1961-1965.
WOODFORTICOSIN Kikuchi, T., Kadota, S., Yokumoto, H., Motegi, a., Takahashi, K. 1991. Woodforticosin as Inhibitor of Topoisomerase and Neoplasms. Patent, Japan Kokai Tokkyo Koho-03 123, 793. 6pp.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Abelmoschus esculentus Okra 2 70
Abelmoschus moschatus Ambrette; Musk Okra; Tropical Jewel Hibiscus; Muskmallow 2 0
Abies balsamea Balsam Fir 1 0
Abutilon theophrasti Velvet Leaf; Butterprint; Indian-Mallow; Abutilon-Hemp 3 0
Acacia catechu Black Cutch; Catechu 4 0
Acacia decurrens Green Wattle 1 0
Acacia farnesiana Cassie; Huisache; Sweet Acacia; Opopanax; Popinac 2 0
Acacia lenticularis 1 46.599998474121094
Acacia leucophloea Pilang Bast 1 0
Acacia modesta 1 0
Acacia nilotica Babul 3 0
Acacia senegal Gum Arabic; Gum Arabic Tree; Kher; Senegal Gum; Sudan Gum Arabic 3 0
Acacia tortilis Umbrella Thorn 1 0
Acalypha indica Cancer Herb; Indian Acalypha; Copperleaf; Indian Nettle; Three-Seeded-Mercury 1 0
Acanthus ilicifolius 1 0
Achillea millefolium Yarrow; Milfoil 3 0
Acinos suaveolens 4 1, 376.4999980926514
Acinos thymoides 1 500
Acrotrema arnottianum 1 650
Actinidia chinensis Kiwi 1 0