SERPENTINE |
50 uM |
Dassonneville, L., et al. 1999. Stimulation of Topoisomerase II-Mediated DNA Cleavage by Three DNA-Intercalating Plant Alkaloids: Cyrptolepine, Matadine, and Serpentine. Biochemistry, 38: 7719-7726. |
SHERMILAMINE-B |
75 uM |
Schmitz, F. J., et al. 1991. Cytotoxic Aromatic Alkaloids From the Ascidian Amphicarpa meridiana and Leptoclinides sp.: Meridine and 11-hydroxyascididemin. J Org Chem, 56: 804-808. |
SHERMILAMINE-B |
IC90=118 uM |
McDonald, L. A., et al . 1994. Inhibition of Topoisomerase II Catalytic Activity by Pyridoacridine Alkaloids From a Cystodytes sp. ascidian: A Mechanism for the Apparent Intercalator-Induced Inhibition of Topoisomerase II. J Med Chem, 37: 3819-3827. |
SHERMILAMINE-C |
IC90=138 uM |
McDonald, L. A., et al . 1994. Inhibition of Topoisomerase II Catalytic Activity by Pyridoacridine Alkaloids From a Cystodytes sp. ascidian: A Mechanism for the Apparent Intercalator-Induced Inhibition of Topoisomerase II. J Med Chem, 37: 3819-3827. |
STAUROSPORINE |
50 nM |
Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318. |
STAUROSPORINE |
IC50=1 uM |
Lassota, P., Singh, G., Kramer, R. 1996. Mechanism of Topoisomerase II Inhibition by Staurosporine and Other Protein Kinase Inhibitors. J Biol Chem, 271: 26418-26423. |
STRICTININ |
IC100=0.5 uM |
Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492. |
TENIPOSIDE |
1-20 uM |
Duke, 1992 * |
TERCHEBIN |
IC100=0.2 uM |
Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492. |
TERPENTECIN |
100 uM |
Duke, 1992 * |
VESCALAGIN |
IC100=0.5 uM |
Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492. |
VESCALAGIN-CARBOXYLIC-ACID |
IC100=0.2 uM |
Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492. |
VIRENAMIDE-A |
IC50=2.5 ug/ml |
Carroll, A. R., Feng, Y. J., Bowden, B. F., Coll, J. C. 1996. Studies of Australian Ascidians. 5. Virenamides A-C, New Cytotoxic Linear Peptides From the Colonial Didemnid Ascidian Diplosoma Virens. J Org Chem, 61: 4059-4061. |
WAKAYIN |
250 uM |
Copp, B. R., Ireland, C. M., Barrows, L. R. 1991. Wakayin: A Novel Cytotoxic Pyrroloiminoquinone Alkaloid From the Ascidian Clavelina Species. J Org Chem, 56: 4596-4597. |
WOODFORDIN-C |
2.5 ug/ml |
Kuramochi-Motegi, A., et al. 1992. Woodfruticosin (Woodfordin C), a New Inhibitor of DNA Topoisomerase II. Experimental Antitumor Activity. Biochem Pharmacol, 44: 1961-1965. |
WOODFORTICOSIN |
not available |
Kikuchi, T., Kadota, S., Yokumoto, H., Motegi, a., Takahashi, K. 1991. Woodforticosin as Inhibitor of Topoisomerase and Neoplasms. Patent, Japan Kokai Tokkyo Koho-03 123, 793. 6pp. |