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| Activity Sort descending | Dosage | Reference |
|---|---|---|
| Topoisomerase-I-Inhibitor | 6.7 nM | Kokoshka, J. M., Capson, T. L., Holden, J. A., Ireland, C. M., Barrows, L. R. 1996. Differences in the Topoisomerase I Cleavage Complexes Formed by Camptothecin and Wakayin, a DNA-Intercalating Marine Natural Product. Anticancer Drugs, 7: 758-765. |
| Topoisomerase-II-Inhibitor | 250 uM | Copp, B. R., Ireland, C. M., Barrows, L. R. 1991. Wakayin: A Novel Cytotoxic Pyrroloiminoquinone Alkaloid From the Ascidian Clavelina Species. J Org Chem, 56: 4596-4597. |