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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
SIDEROXYLONAL-A IC50=1.25 uM Satoh, H., Etoh, H., Watanobe, N., Kawagishi, H., Arai, K., Ina, K. Structures of Sideroxylonals from Eucalyptus sideroxylon. Chem Lett, 1992(10): 1917-1920.
SIDEROXYLONAL-B IC50=2.47 uM Satoh, H., Etoh, H., Watanobe, N., Kawagishi, H., Arai, K., Ina, K. Structures of Sideroxylonals from Eucalyptus sideroxylon. Chem Lett, 1992(10): 1917-1920.
SKULLCAPFLAVONE-II 500 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
SOPHORICOSIDE IC18=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
SORBARIN IC70=10uM; IC14=1uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
SPIRAEOSIDE IC51=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
SPIRAEOSIDE IC9=1 uM *
SUDACHIIN-A 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
SUDACHITIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
SUDACHITIN-7-O-BETA-D-GLUCOSIDE 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
SUGIOL Tezuka, Y., Kasimu, R., Basnet, P., Namba, T., Kadota, S. 1997. Aldose Reductase Inhibitory Constituents of the Root of Salvia miltiorhiza Bunge. Chem Pharm Bull, 45(8): 1306-1311.
TANNIC-ACID IC50=1.8 ug/ml Sawada, H., Hamatake, M., Hara, A., Nakagawa, M., Nakayama, T. 1989. Inhibition of Human Placenta Aldose Reductase by Tannic Acid. Chem Pharm Bull, 37(6): 1662-1664.
TANSHINONE-I IC50=4.8 uM rat *
TANSHINONE-II-A IC50=1.14 uM rat *
TAXIFOLIN 60 uM pig Haraguchi, H., Ohmi, I., Masuda, H., Tamura, Y., Mizutani, K., Tanaka, O., Chou, W. H. 1996. Inhibition of Aldose Reductase by Dihydroflavonols in Engelhardtia chrysolepis and Effects on Other Enzymes. Experientia, 52(6): 564-567.
THERMORUBIN IC50=0.006 uM cow Nakayama, M., et al. 1996. Thermorubin from Cultured Thermoactinomyces UAT-8 as Aldose Reductase Inhibitor and Pharmaceutical Compositions Containing Thermorubin for Diabetic Complications. Patent, Japan Kokai Tokkyo Koho-08 59,462. 5pp.
THIAZOCIN-A IC50=0.455 uM Ozasa, T., Yoneda, T., Hirasawa, M., Suzuki, K., Tanaka, K., Kadota, S., Iwanami, M. 1991. Thiazocins, New Aldose Reductase Inhibitors from Actinosynnema sp. I. Fermentation, Isolation and Characterization. J Antibiot, 44(7): 768-773.
THIAZOCIN-B IC50=0.220 uM Ozasa, T., Yoneda, T., Hirasawa, M., Suzuki, K., Tanaka, K., Kadota, S., Iwanami, M. 1991. Thiazocins, New Aldose Reductase Inhibitors from Actinosynnema sp. I. Fermentation, Isolation and Characterization. J Antibiot, 44(7): 768-773.
THYMONIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
THYMUSIN 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Garcinia mangostana Mangosteen; Mangostin 1 510
Gardenia jasminoides Gardenia; Shan-Chih-Tzu; Shan-Zhi-Zi; Zhi Zi; Jasmin; Cape Jasmine 1 0
Gaultheria fragrantissima Indian Wintergreen 1 0
Gaultheria procumbens Teaberry; Wintergreen; Checkerberry; Creeping Wintergreen; Mountain Tea; Wintergrun (Ger.) 4 0
Gelsemium sempervirens Yellow Jessamine 1 0
Genipa americana Genipap; Jagua 1 2, 040
Genista clavata 1 0
Genista germanica 1 0
Genista lydia 1 0
Genista ovata 1 0
Genista patula 1 0
Genista rumelica 1 0
Genista sp 1 0
Genista tinctoria Dyer's Broom 1 0
Gentiana lutea Yellow Gentian; Gentian 3 366
Geranium thunbergii Gennoshiouko; Oriental Geranium 3 0
Ginkgo biloba Ginkgo; Maidenhair Tree 15 194, 386
Glaucium flavum Horned Poppy 1 0
Glechoma hederacea Alehoof 13 26, 027
Glehnia littoralis Bei Sha Shen 1 0