Plant Actaea cimicifuga (Ranunculaceae)
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Common name(s)
Bugbane, Foetid Bugbane, Sheng ma
How used
Medicinal
Data Views
# Activity | Chemical Name | Part | Low PPM | High PPM | StdDev | *Reference |
---|---|---|---|---|---|---|
102 | CAFFEIC-ACID | Rhizome | -- | -- | -- | * |
Aldose-Reductase-Inhibitor 4 ug/ml (weak activity)
Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.
Allergenic
*
Analgesic
*
Antiadenoviral
Economic & Medicinal Plant Research, 5: 207.
Antiaggregant
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antiaging
*
Antiatherogenic
*
Antibacterial
*
Anticancer
*
Anticarcinogenic
Economic & Medicinal Plant Research, 6: 189.
Antidepressant
*
Antiedemic
Economic & Medicinal Plant Research, 6: 189.
Antielastase IC50=86 ug/ml (475 uM)
*
Antielastase IC50=93 um/l
*
Antiescherichic
*
Antiflu
Economic & Medicinal Plant Research, 5: 207.
Antigonadotropic
Jim Duke's personal files.
Antihemolytic 25 uM
Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., and Kido, R. 1993. Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. Phytochemistry. 36(3): 579-583. 1994.
Antihepatoadenomic 200 ppm diet orl mus
*
Antihepatotoxic
*
Antiherpetic EC50=>50 ug/ml
*
Antiherpetic 50 ug/ml
*
Antihistaminic
*
AntiHIV EC50=200 ug/ml
*
Antihypercholesterolemic
Economic & Medicinal Plant Research, 6: 189.
Antihyperthyroid
*
Antiinflammatory
*
AntiLegionella
*
Antileukemic
Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46.
Antileukotriene
*
Antimelanogenic
*
Antimutagenic
Ki Soon Rhee. Oilseed Food Ingredients Used To Minimize Oxidative Flavor Deterioration in Meat Products. Phenolic Compounds in Food and Their Effects on Health, Ch.18.
Antinitrosaminic
Ki Soon Rhee. Oilseed Food Ingredients Used To Minimize Oxidative Flavor Deterioration in Meat Products. Phenolic Compounds in Food and Their Effects on Health, Ch.18.
Antiophidic
*
Antioxidant 1/3 quercetin
*
Antioxidant IC57=30 ppm
*
Antioxidant 30 mM
*
Antioxidant 1/2 BHA
*
Antioxidant 1.3 x Vit. E
*
Antioxidant 50 uM
*
Antiperoxidant IC85=100 ug/ml
*
Antiperoxidant IC50=44 uM
Planta Medica, 57: A54, 1991.
Antiperoxidant IC35=200 ug/ml
*
Antiproliferant
Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46.
Antiprostaglandin
*
Antiradicular 1/3 quercetin
*
Antiradicular 30 mM
*
Antiradicular 10 uM
Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., and Kido, R. 1993. Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. Phytochemistry. 36(3): 579-583. 1994.
Antiradicular IC50=32-35 uM
*
Antiseptic
*
Antispasmodic EC50=3.4-15 uM
Phytotherapy Research, 4: 73.
Antistaphylococcic
*
Antistomatitic
Economic & Medicinal Plant Research, 5: 207.
Antisunburn
*
Antithiamin
Phenolic Compounds in Food and Their Effects on Health, 69.
Antithyroid
Jim Duke's personal files.
Antitumor 200 ppm diet orl mus
*
Antitumor (Skin)
*
Antitumor-Promoter IC42=10 uM
Cancer Research, 48: 5941.
Antiulcerogenic
*
Antivaccinia
Economic & Medicinal Plant Research, 5: 207.
Antiviral IC50=62.5 ug/ml
*
Anxiolytic
*
Calcium-Antagonist IC50=1.2 uM rbt
*
Cancer-Preventive
Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Carcinogenic 2% (diet)
*
Chemopreventive
*
Cholagogue
Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp.
Choleretic
Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Clastogenic
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
CNS-Active
Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp.
Co-carcinogenic
*
Collagen-Sparing
*
COX-2-Inhibitor IC32=100 uM
*
Cytoprotective
Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
Cytotoxic TC50=200 ug/ml
*
Diuretic
Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp.
DNA-Active
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
DNA-Protective
*
Fungicide MIC=0.4 mg/ml
*
Hepatocarcinogenic 400 ppm diet orl mus (in the absence of alcohol)
*
Hepatoprotective
Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 210.
Hepatotropic
*
Histamine-Inhibitor
*
Immunostimulant
*
Insectifuge
Tunon, H., Thorsell, W., and Bohlin, L. 1993. Mosquito Repelling Activity of Compounds Occurring in Achillea millefolium L. (Asteraceae). Economic Botany 48(2): 111-120, 1994.
Leukotriene-Inhibitor
*
Lipoxygenase-Inhibitor IC27=5 mM
Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690.
Lipoxygenase-Inhibitor IC50=62-148 uM
*
Lyase-Inhibitor IC50=94-164 uM
*
Metal-Chelator
McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25.
Ornithine-Decarboxylase-Inhibitor
Hagerman, A.E. Tannin-Protein Interactions. Phenolic Compounds in Food and Their Effects on Health, Ch.19.
Pesticide
*
Prooxidant
*
Prostaglandigenic
*
Sedative 500 mg
*
Sunscreen IC50=2.5 mg/l
Lazarova*, G., Kostova, I., Neychev, H. 1992. Photodynamic damage prevention by some hydroxycoumarins. Fitoterapia 64(2): 134-136, 1993.
Sunscreen IC91=5 mg/l
Lazarova*, G., Kostova, I., Neychev, H. 1992. Photodynamic damage prevention by some hydroxycoumarins. Fitoterapia 64(2): 134-136, 1993.
Sunscreen IC98=25 mg/l
Lazarova*, G., Kostova, I., Neychev, H. 1992. Photodynamic damage prevention by some hydroxycoumarins. Fitoterapia 64(2): 134-136, 1993.
Tumorigenic
Jim Duke's personal files.
Vulnerary
*
Xanthine-Oxidase-Inhibitor IC50=39.21 uM
Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill
Livinston, Edinburgh.
|
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0 | CIMIFUGINE | Rhizome | -- | -- | -- | * |
61 | FERULIC-ACID | Rhizome | -- | -- | -- | * |
Allelopathic
Holappa, L.D., and Blum*, U. 1991. Effects of Exogenously Applied Ferulic Acid, a Potential Allelopathic Compound, on Leaf Growth, Water Utilization, and Endogenous Abscisic Acid Levels of Tomato, Cucumber, and Bean. J. of Chemical Ecology, 17(5): 865.
Analgesic
Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 69.
Antiaggregant
Ozaki, Y. and Ma, J-P. 1989. Inhibitory Effects of Tetramethylpyrazine and Ferulic Acid on Spontaneous Movement of Rat Uterus in Situ. Chem. Pharm. Bull. 38(6): 1620-1623, 1990.
Antiallergic
Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.
Antiarrhythmic
*
Antibacterial
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Anticancer (Colon)
*
Anticancer (Forestomach)
*
Anticancer (Liver)
*
Anticancer (Skin)
*
Anticarcinogenic
*
Antidysmenorrheic
*
Antiestrogenic
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antihepatotoxic
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antiherpetic
*
Antiinflammatory
Hagerman, A.E. Tannin-Protein Interactions. Phenolic Compounds in Food and Their Effects on Health, Ch.19.
Antileukemic IC50=25-56 ug/ml
Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46.
Antimitotic
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antimutagenic
Ki Soon Rhee. Oilseed Food Ingredients Used To Minimize Oxidative Flavor Deterioration in Meat Products. Phenolic Compounds in Food and Their Effects on Health, Ch.18.
Antineoplastic (Stomach)
*
Antinitrosaminic
Ki Soon Rhee. Oilseed Food Ingredients Used To Minimize Oxidative Flavor Deterioration in Meat Products. Phenolic Compounds in Food and Their Effects on Health, Ch.18.
Antioxidant 1/3 quercetin
*
Antioxidant 3,000 uM
*
Antioxidant IC51=200 ppm
*
Antioxidant 1/2 BHA
*
Antioxidant EC50=9-15 ug/ml
*
Antiradicular EC50=9-15 ug/ml
*
Antiradicular IC50=116-124 uM
*
Antiserotonin
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antispasmodic
Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.
Antithrombic
Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.
Antitumor
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antitumor (Colon)
*
Antitumor (Forestomach)
*
Antitumor (Liver)
*
Antitumor (Skin)
*
Antitumor-Promoter IC46=10 uM
Cancer Research, 48: 5941.
Antiviral
Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.
Arteriodilator
Ozaki, Y. and Ma, J-P. 1989. Inhibitory Effects of Tetramethylpyrazine and Ferulic Acid on Spontaneous Movement of Rat Uterus in Situ. Chem. Pharm. Bull. 38(6): 1620-1623, 1990.
Cancer-Preventive
Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Candidicide
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Cardiac
Ozaki, Y. and Ma, J-P. 1989. Inhibitory Effects of Tetramethylpyrazine and Ferulic Acid on Spontaneous Movement of Rat Uterus in Situ. Chem. Pharm. Bull. 38(6): 1620-1623, 1990.
Cholagogue
Pharmazie, 46: 156, 1991.
Choleretic
Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Fungicide
Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.
Hepatoprotective
Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill
Livinston, Edinburgh.
Hepatotropic
*
Herbicide
Angewandte Botanik 68(5/6)=1994. Page 195.
Hydrocholerectic
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Hypolipidemic
*
Immunostimulant
Economic & Medicinal Plant Research, 1: 124.
Insectifuge
Tunon, H., Thorsell, W., and Bohlin, L. 1993. Mosquito Repelling Activity of Compounds Occurring in Achillea millefolium L. (Asteraceae). Economic Botany 48(2): 111-120, 1994.
Metal-Chelator
McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25.
Ornithine-Decarboxylase-Inhibitor
Hagerman, A.E. Tannin-Protein Interactions. Phenolic Compounds in Food and Their Effects on Health, Ch.19.
Pesticide
*
Phagocytotic
*
Preservative
Merck 11th Edition
Prostaglandigenic
*
Prostaglandin-Synthesis-Inhibitor 0.58-3.2 mM
Xu, L. N., Yu, W. G., Tian, J. Y., Liu, Q. Y. 1990. Effect of Sodium Ferulate on Arachidonic Acid Metabolism. Yao Hsueh Hsueh Pao, 25(6): 412-416.
Sunscreen
Chemical Marketing Reporter; a weekly tabloid, 9/10/92.
Uterosedative 30-100 mg/kg ivn rat
Ozaki, Y. and Ma, J-P. 1989. Inhibitory Effects of Tetramethylpyrazine and Ferulic Acid on Spontaneous Movement of Rat Uterus in Situ. Chem. Pharm. Bull. 38(6): 1620-1623, 1990.
|
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34 | SALICYLIC-ACID | Rhizome | -- | -- | -- | * |
Aldose-Reductase-Inhibitor 724.6 uM
Toyomizu, M., Sugiyama, S., Jin, R. L., Nakatsu, T. 1993. Alpha-Glucosidase and Aldose Reductase Inhibitors: Constituents of Cashew, Anacardium occidentale, Nut Shell Liquids. Phytotherapy Research, 7(3): 252-254.
Analgesic
*
Antiarthritic
Madaus, G. 1976. Lehrbuch der Biologischen Hilfmittel. Vol,. 1-3. 2862 pp. (+ 144 p. index). Georg Olms Verlag, Hildescheim. Reprint of 1938 Madaus.
Antibacterial
Martindale's 28th
Antidandruff
A.L.L. Hunting. Encyclopedia of Shampoo Ingredients. Micelle Press, Cranford NJ. 467 pp.
Antidermatotic
*
Antieczemic
*
Antiichthyosic
Martindale's 29th
Antiinflammatory
Pharmazie, 46: 156, 1991.
Antineuralgic
Madaus, G. 1976. Lehrbuch der Biologischen Hilfmittel. Vol,. 1-3. 2862 pp. (+ 144 p. index). Georg Olms Verlag, Hildescheim. Reprint of 1938 Madaus.
Antioncychomycotic
Martindale's 29th
Antioxidant
Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.
Antiperiodic
*
Antipodagric
*
Antipsoriac
*
Antipyretic
*
Antirheumatic
*
Antiseborrheic
*
Antiseptic
A.L.L. Hunting. Encyclopedia of Shampoo Ingredients. Micelle Press, Cranford NJ. 467 pp.
Antitumor
*
Antitympanitic
Merck 11th Edition
Cancer-Preventive
Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Comedolytic
Martindale's 29th
COX-2-Inhibitor
Newmark, T. M. and Schulick, P. 2000. Herbal Cox-2 Inhibition - Nature's Challenge to Arthritis, Cancer & Alzheimer's Disease. Hohm Press, Prescott AZ.
Cyclooxygenase-Inhibitor
*
Dermatitigenic
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Fungicide MIC 1,000 ug/ml
*
Hypoglycemic
Economic & Medicinal Plant Research, 6: 158.
Insectifuge
Tunon, H., Thorsell, W., and Bohlin, L. 1993. Mosquito Repelling Activity of Compounds Occurring in Achillea millefolium L. (Asteraceae). Economic Botany 48(2): 111-120, 1994.
Keratolytic
Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Pesticide
*
Thermogenic 130 ppm
*
Tineacide
Martindale's 29th
Ulcerogenic
*
|
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35 | TANNIN | Rhizome | -- | -- | -- | * |
Anthelmintic
*
Antibacterial
*
Anticancer
*
Anticariogenic
*
Antidiarrheic
*
Antidysenteric
*
Antihepatotoxic
*
AntiHIV
*
Antihypertensive
*
Antilipolytic
*
Antimutagenic
*
Antinephritic
Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990.
Antiophidic
Economic & Medicinal Plant Research, 5: 363.
Antioxidant 1/3 quercetin
*
Antioxidant IC50=1.44 ug/ml
*
Antiradicular 1/3 quercetin
*
Antiradicular 500 mg/kg/day orl mus
Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990.
Antirenitic
Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990.
Antitumor
*
Antitumor-Promoter
*
Antiulcer
*
Antiviral
*
Cancer-Preventive
HerbalGram No. 22 - Spring 1990, page 14.
Carcinogenic
*
Chelator
*
Cyclooxygenase-Inhibitor
*
Glucosyl-Transferase-Inhibitor
*
Hepatoprotective
*
Immunosuppressant
*
Lipoxygenase-Inhibitor
*
MAO-Inhibitor
*
Ornithine-Decarboxylase-Inhibitor
*
Pesticide
*
Psychotropic
Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990.
Xanthine-Oxidase-Inhibitor
*
|
# Activity | Chemical Name | Part | Low PPM | High PPM | StdDev | *Reference |
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# Chemical | Activity Name | *Reference |
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*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.