Hyptis capitata | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Knobweed

How used

Medicinal

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Activities: 80

Chemicals w/Activities: 3

All Chemicals: 5

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# Activity	Chemical Name	Part	Low PPM	High PPM	StdDev	^*Reference
0	2ALPHA-HYDROXYURSOLIC-ACID	Shoot	--	--	--	Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095.
0	HYPTACTIC-ACID	Shoot	--	--	--	Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095.
2	POMOLIC-ACID	Shoot	--	--	--	Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095.
AntiHIV IC50=23.3 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. AntiHIV EC50=1.4 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095.
1	TORMENTIC-ACID	Shoot	--	--	--	Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095.
Hypoglycemic 10 ppm *
89	URSOLIC-ACID	Shoot	--	--	--	Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095.
Analgesic * Antialzheimeran Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215. Antiarrhythmic * Antiarthritic Planta Medica, 57: A56, 1991. Antibacterial * Anticancer Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215. Anticancer (Colon) Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215. Anticarcinomic Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Anticariogenic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Anticholestatic 28-100 mg/kg orl Shukla, B., Visen, P.K.S., Patnaik, G.K., Tripathi, S.C., Srimal, R.C., Dayal, R., and Dobhal, P.C. Hepatoprotective Activity in the Rat of Ursolic Acid Isolated from Eucalyptus Hybrid. Phytotherapy Research 6: 74-79, 1992. Anticomplement IC100 0.1 mM/l gpg Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Anticomplement IC80-90 0.05 mM/l gpg Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Antidiabetic Chemical Constituents of Oriental Herbs (3 diff. books) AntiEBV Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antiedemic * Antiescherichic * Antifibrosarcomic IC80=10 uM * Antihepatotoxic 5-20 mg/kg ipr Shukla, B., Visen, P.K.S., Patnaik, G.K., Tripathi, S.C., Srimal, R.C., Dayal, R., and Dobhal, P.C. Hepatoprotective Activity in the Rat of Ursolic Acid Isolated from Eucalyptus Hybrid. Phytotherapy Research 6: 74-79, 1992. Antihistaminic Tsuruga, T., Chun, Y.-T., Ebizuka, Y., and Sankawa, U. 1991. Biologically Active Constituents of Melaleuca leucadendron: Inhibitors of Induced Histamine Release from Rat Mast Cells. Chem. Pharm. Bull. 39(12): 3276-3278, 1991. AntiHIV 6.7 uM * AntiHIV EC50=2.0 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. AntiHIV IC50=6.5 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. AntiHIV IC85=18 ug/ml * Antihyperlipidemic * Antiinflammatory 1/3 indomethacin * Antiinflammatory IC24=500 mg/kg * Antileishmanic ED50=20 uM * Antileukemic IC50=2.5-17.8 ug/ml * Antilymphomic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antimalarial IC50=28-37 ug/ml * Antimetastatic IC80=10 uM * Antimutagenic IC57-80=80 mg/kg * Antinephritic IC50=6-7.5 uM * Antiobesity? Internat. J. Oriental Med. 16: 4. Antioxidant IC50=10 uM * Antiperoxidant IC35=200 ug/ml * Antiplasmodial IC50=28-37 ug/ml * Antiproliferative IC50=15-20 uM * Antistaphylococcic * AntiTGF-beta IC50=6-7.5 uM * Antithromboxane IC50=50 uM * Antitrypanosomic * Antitumor Cancer Research, 54: 701, 1994. Antitumor (brain) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Breast) 0.5% diet * Antitumor (Breast) IC50=15-20 uM * Antitumor (Cervix) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Colon) * Antitumor (Lung) * Antitumor (Ovary) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Stomach) IC50=15-20 uM * Antitumor-Promoter Planta Medica, 57: A56, 1991. Antiulcer Shukla, B., Visen, P.K.S., Patnaik, G.K., Tripathi, S.C., Srimal, R.C., Dayal, R., and Dobhal, P.C. Hepatoprotective Activity in the Rat of Ursolic Acid Isolated from Eucalyptus Hybrid. Phytotherapy Research 6: 74-79, 1992. Antiviral IC85=18 ug/ml * Aromatase-Inhibitor * Beta-Blocker * Beta-Glucuronidase-Inhibitor ~100 mg/kg * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidicide * Cardioprotective * Cardiotonic * Choleretic 5-20 mg/kg orl Shukla, B., Visen, P.K.S., Patnaik, G.K., Tripathi, S.C., Srimal, R.C., Dayal, R., and Dobhal, P.C. Hepatoprotective Activity in the Rat of Ursolic Acid Isolated from Eucalyptus Hybrid. Phytotherapy Research 6: 74-79, 1992. CNS-Depressant * COX-2-Inhibitor IC50=130 uM/ * Cyclooxygenase-Inhibitor Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215. Cytotoxic 50 ppm * Cytotoxic ED50=3.75 ug/ml * Cytotoxic 7.2 uM * Diuretic * Elastase-Inhibitor IC50=~15 uM * Hepatoprotective 10 mg/kg * Hepatoprotective 1-100 ug/ml * Hypoglycemic Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989. Hypotensive * Immunomodulator * Leucocytogenic * Lipoxygenase-Inhibitor IC50=0.18 mM * MMP-9-Inhibitor IC80=10 uM * Ornithine-Decarboxylase-Inhibitor * Pesticide * Piscicide * Potassium-Sparing 3 mg/rat Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Protease-Inhibitor IC85=18 ug/ml * Protisticide Chemical Express, 7: 285, 1992. Quinone-Reductase-Inducer 5 ug/ml Lee, S. K., Song, Y., Mata-Greenwood, E., Kelloff, G. J., Steele, V. E., Pezzuto, J. M. 1999. Modulation of in vitro Biomarkers of the Carcinogenic Process by Chemopreventive Agents. Anticancer Res., 19: 35-44. Sodium-Sparing 3 mg/rat Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. TOPO-2-Inhibitor * Trypanocide * Vasopressor *

^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Hyptis capitata (Lamiaceae)

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