Nerium oleander | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Oleander

How used

Medicinal

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Activities: 334

Chemicals w/Activities: 34

All Chemicals: 66

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Exclude ubiquitous chemicals - View the list of ubiquitous chemicals

List of all chemical
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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
0	16-ANHYDRO-DEACETYL-NERIGOSIDE	Seed	--	--	--	*
0	9-D-HYDROXY-CIS-12-OCTADECANOIC-ACID	Seed	--	--	--	*
0	ADIGOSIDE	Plant	--	--	--	*
3	ADYNERIN	Leaf	--	--	--	*
Antitumor * Cardiac Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Toxic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
0	ALKALOIDS	Flower	--	10.0	-1.47	*
0	ALKALOIDS	Leaf	--	50.0	-0.61	*
0	ALKALOIDS	Stem	--	20.0	-1.44	*
10	ALPHA-AMYRIN	Plant	--	--	--	*
Analgesic * Antiedemic IC43=40 mg/kg ipr rat * Antiinflammatory IC71=1,000 ppm orl * Antinociceptive * Antitumor * Antiulcer * Cytotoxic 50-400 * Gastroprotective * Hepatoprotective * Insectifuge *
47	BETA-SITOSTEROL	Plant	--	--	--	*
Androgenic * Angiogenic * Anorexic Martindale's 28th Antiadenomic Merck 11th Edition Antiandrogenic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antibacterial Recently became Internat. J. Crude Drug Res. 28(1,2,3,4):1990, page 155. Anticancer (Breast) Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103. Anticancer (Cervix) * Anticancer (Lung) * Antiedemic IC54=320 mg/kg orl * Antiestrogenic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antifeedant Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Antifertility Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antigonadotrophic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antihyperlipoproteinaemic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiinflammatory * Antileukemic * Antilymphomic * Antimutagenic 250 ug/ml * Antiophidic 2.3 mg mus Economic & Medicinal Plant Research, 5: 363. Antioxidant IC44=10 uM * Antiprogestational Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antiprostaglandin 30 mg/day/12 wks * Antiprostatadenomic Merck 11th Edition Antiprostatitic 10-20 mg 3 x/day/orl man * Antipyretic Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Antitumor (Breast) Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103. Antitumor (Cervix) * Antitumor (Lung) * Antiviral Abid Ali Khan, M.M., Jain, D.C., Bhakuni, R.S., Zaim, M., and Thakur, R.S. 1991. Occurrence of some antiviral sterols in Artemisia annua. Plant Science, 75: 161-165, 1991. Apoptotic * Artemicide LC50=110 ppm Jung, J.H., Pummangura, S., Chaichantipyuth, c., Patarapanich, C., and McLaughlin, J.L. 1989. Bioactive Constituents of Melodorum fruticosum. Phytochemistry. 29(5): 1667-1670. 1990. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidicide Recently became Internat. J. Crude Drug Res. 28(1,2,3,4):1990, page 155. Caspase-8-Inducer * Estrogenic * Febrifuge Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Gonadotrophic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Hepatoprotective * Hypocholesterolemic 2-6 g/man/day/orl Martindale's 30th Hypocholesterolemic 9-3,330 mg/man/day/orl Martindale's 28th Hypoglycemic Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989. Hypolipidemic 2-6 g/day * Pesticide * Spermicide Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Ubiquiot Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Ulcerogenic 500 mg/kg ipr rat *
13	BETULIN	Leaf	--	--	--	Jim Duke's personal files.
Anticarcinomic * Antifeedant * Antiflu * AntiHIV 6.1 uM * Antiinflammatory Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas. Planta Medica, 61: 9. Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral 6.1 uM Aphidifuge Lugemwa, F.N., Huang, F-Y., Bentley, M.D., Mendel, M.J., and Alford, A.R. 1990. A Heliothis zea Antifeedant from the Abundant Birchbark Triterpene Betulin. J. Agric. Food Chem. 38(2): 493-494. Cytotoxic 600 ppm * Cytotoxic 8.6 uM * Hypolipemic * Prostaglandin-Synthesis-Inhibitor IC50=119 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626. Topoisomerase-II-Inhibitor IC50=38.6 uM *
22	BETULINIC-ACID	Leaf	--	--	--	Jim Duke's personal files.
Anthelmintic * Antibacterial * Anticancer Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Anticarcinomic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiedemic * AntiHIV 14.8 uM * AntiHIV IC50=6.5 ug/ml * AntiHIV EC50=2.0 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. Antiinflammatory Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas. Planta Medica, 61: 9. Antileukemic Antimalarial IC50=19-26 ug/ml * Antimelanomic New York Times, 3/28/95. Antinociceptive * Antiplasmodial IC50=19-26 ug/ml * Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral 14.8 uM * Apoptotic * Cytotoxic 50-100 ppm Biosyn. Prod. Cancer Chemotherapy (Petit et al) Cytotoxic 16.4 uM * Phospholipase-A2-Inhibitor * Prostaglandin-Synthesis-Inhibitor 200 ug/ml Dunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497. Prostaglandin-Synthesis-Inhibitor IC50=101 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.
2	CAMPESTEROL	Plant	--	--	--	*
Antioxidant IC37=10 uM * Hypocholesterolemic Duke, J. A. Writeups or information summaries on approximately 2,000 economic plants, USDA, ARS, Beltsville, MD 20705.
0	CAOUTCHOUC	Plant	--	490.0	-1.11	*
3	CAPRIC-ACID	Seed	--	--	--	*
Fungicide * Irritant * Pesticide *
1	CAPROIC-ACID	Seed	--	--	--	*
Irritant *
5	CAPRYLIC-ACID	Seed	--	--	--	*
Antiseptic * Candidicide 300 mg/man/12 x/day * Fungicide * Irritant * Pesticide *
20	CHOLINE	Plant	--	--	--	*
Antialzheimeran 5-16 g/man/day * Antichoreic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Anticirrhotic 6,000 mg/man/day * Anticystinuric * Antidementia * Antidiabetic * Antidyskinetic 150-200 mg/kg/man/day Martindale's 28th Antihomocysteine * Antimanic 15-30 g/man/day/orl Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antinociceptive * Antisteatotic * Cardiodepressant * Cerebrotonic * Cholinergic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Hepatoprotective * Hypotensive * Ileorelaxant * Lipotropic * Memorigenic * Parasympathomimetic (1/1,000th acetylcholine) Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
2	CORNERIN	Leaf	--	--	--	*
Cardiac * Diuretic *
0	CORTENERIN	Leaf	--	--	--	*
0	DEACETYLOLEANDRIN	Leaf	--	--	--	*

List of all activity chemical
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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Nerium oleander (Apocynaceae)

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