Mucuna pruriens | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Cowage, Velvetbean

How used

Medicinal

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Activities: 72

Chemicals w/Activities: 1

All Chemicals: 2

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# Activity	Chemical Name	Part	Low PPM	High PPM	StdDev	^*Reference
81	GENISTEIN	Leaf Diffusate	--	6.0	-0.49	*
Abortifacient Cooper-Driver, G. A., Chemical substances in plants toxic to animals, pp. 213-47 in Rechcigl, M., Jr., ed. CRC Handbook of Naturally Occurring Food Toxicants, CRC Press, Boca Raton, 1983, 339 pp. Aldose-Reductase-Inhibitor IC50=10 uM * Alpha-Reductase-Inhibitor IC50=35 uM * Antiaggregant 1-10 ug/ml Medline (post 1990 searches filed in my computer) Antiangiogenic 150 uM * Antiatherosclerotic Journal of Medicinal Food 2: 163.1999. Anticancer (Breast) IC50=2.6-6.7 ug/ml * Anticarcinomic (Breast) IC50=?640 uM Medline (post 1990 searches filed in my computer) Anticlimacteric Duke, J. A. Writeups or information summaries on approximately 2,000 economic plants, USDA, ARS, Beltsville, MD 20705. Antiendoccytotic 100 ug/ml Medline (post 1990 searches filed in my computer) Antiestrogenic * Antifertility * Antihemolytic * Antiimplantation * Antiinflammatory Journal of Medicinal Food 2: 179.1999. Antiischemic Medline (post 1990 searches filed in my computer) Antileukemic >50 ug/ml (185 uM) * Antileukemic IC50=0.010 ug/ml Life Sciences 55: 1061. Antileukotriene IC50=10-15 uM Medline (post 1990 searches filed in my computer) Antilymphomic * Antimelanomic Medline (post 1990 searches filed in my computer) Antimicrobial * Antimitogenic IC50=12 uM * Antimutagenic ID50=50-100 nM Maga, J.A. Contribution of Phenolic Compounds to Smoke Flavor. Phenolic Compounds in Food and Their Effects on Health, Ch.13. Antineuroblastomic * Antiosteoporotic * Antioxidant Phenolic Compounds in Food and Their Effects on Health, 64. Antiproliferative 5-45 uM * Antiprostatadenomic 8-27 ug/ml Medline (post 1990 searches filed in my computer) Antiprostatitic IC50=35 uM * Antispasmodic IC50=34 uM * Antitumor (Breast) * Antitumor (GI) * Antitumor (Ovary) * Antitumor (Prostate) * Antitumor (Stomach) * Antiulcer? * Antiviral * Apoptotic * Aromatase-Inhibitor IC30=1 uM/l Journal of Medicinal Food 2: 235.1999. Calcium-Antagonist 50 uM gpg * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardioprotective Journal of Medicinal Food 2: 163.1999. Catechol-O-Methyltransferase-Inhibitor * Cytotoxic IC89=10 ug/ml Planta Medica, 57: A113, 1991. Cytotoxic >50 ug/ml (185 uM) Medline (post 1990 searches filed in my computer) DOPA-Decarboxylase-Inhibitor * Estrogen-Agonist 0.1-1 uM/l Journal of Medicinal Food 2: 139.1999. Estrogenic EC50=0.1-25 uM/l * Flatulent * Fungicide 2.5 mM Geibel, M. 1994. Sensitivity of the Fungus Cytospora persoonii to the Flavonoids of Prunus cerasus. Phytochemistry. 38(3): 599-601. 1995. Fungicide ED50=50->100 * Fungistat IC34=200 uM * Histidine-Kinase-Inhibitor IC50=110 uM Medline (post 1990 searches filed in my computer) Hypocholesterolemic ED50=0.5 mg/kg * Immunostimulant 2-20 mg/kg orl mus * Lipase-Inhibitor * MAO-Inhibitor IC50=60-140 uM * MAO-Inhibitor IC50=95 * MDR-Inhibitor 200 uM Castro, A. F., Altenberg, G. A. 1997. Inhibition of Drug Transport by Genistein in Multidrug-Resistant Cell Expressing P-Glycoprotein. Biochem Pharmacol, 53(1): 89-93. NADH-Ubiquinone-Oxidoreductase-Inhibitor * Natriuretic * Ornithine-Decarboxylase-Inhibitor * Peroxidase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide * Phytoalexin Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Pituitary-sensitizer Medline (post 1990 searches filed in my computer) PTK-Inhibitor 10-100 uM * Quinone-Reductase-Inducer IC50=4.6 ug/ml * Topoisomerase-I-Inhibitor IC50=250 ppm * Topoisomerase-I-Inhibitor 1-10 ug/ml Okura, A., Arakawa, H., Oka, H., Yoshinari, T., Monden, Y. 1988. Effect of Genistein on Topoisomerase Activity and on the Growth of [VAL 12]HA-RAS-Transformed NIH 3T3 Cells. Biochem Biophys Res Commun, 157: 183-189. Topoisomerase-II-Inhibitor IC50=30 ug/ml Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225. Topoisomerase-II-Inhibitor 20 uM Markovits, J., et al. 1989. Inhibitory Effects of the Tyrosine Kinase Inhibitor Genistein on Mammalian DNA Topoisomerase II. Cancer Research, 49: 5111-5117. Topoisomerase-II-Inhibitor IC50=1-150 uM * Topoisomerase-II-Inhibitor 2-7.5 ug/ml * Topoisomerase-II-Poison Journal of Medicinal Food 2: 167.1999. Trypanosomastat Medline (post 1990 searches filed in my computer) Tyrosine-Kinase-Inhibitor * Uterotrophic EC50=0.1-25 uM/l * Uterotrophic ED50=0.5 mg/kg * VEGF-Inhibitor *
0	HYDROXYGENISTEIN	Leaf Diffusate	--	14.0	0.08	*

^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Mucuna pruriens (Fabaceae)

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