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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Topoisomerase-II-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-DICENTRINE IC50=27 uM Woo, S. H., Sun, N. J., Cassady, J. M., Snapka, R. M. 1999. Topoisomerase II Inhibition by Aporphine Alkaloids. Biochem Pharmacol, 57: 1141-1145.
1,2,3,4,6-PENTA-O-GALLOYL-BETA-D-GLUCOSE IC100=0.2 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
1,2,6-TRI-O-GALLOYL-BETA-D-GLUCOSE IC100=0.2 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
1,3,4,5-TETRA-O-GALLOYL-QUINIC-ACID IC100=0.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
1-2-3-6-TETRA-O-GALLOYL-BETA-D-GLUCOSE IC100=0.2 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
1-BETA-GALLOYL-PEDUNCULAGIN IC100=0.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
10-HYDROXYLIRIODENINE IC50=12.5 ug/ml Harrigan, G. G., Gunatilaka, A. A. L., Kingston, D. G. I., Chan, G. W., Johnson, R. K. 1994. Isolation of Bioactive and Other Oxoaporphine Alkaloids From Two Annonaceous Plants, Xylopia aethiopica and X. muliusa cf. banacea. J Natural Products, 57: 68-73.
10-METHOXYLIRIODENINE IC50=25 ug/ml Harrigan, G. G., Gunatilaka, A. A. L., Kingston, D. G. I., Chan, G. W., Johnson, R. K. 1994. Isolation of Bioactive and Other Oxoaporphine Alkaloids From Two Annonaceous Plants, Xylopia aethiopica and X. muliusa cf. banacea. J Natural Products, 57: 68-73.
14-CHLORO-15-HYDROXYXESTOQUINONE IC90=135 uM Concepcion, G. P., Foderaro, T. A., Eldredge, G. S., Lobkovsky, E., Clardy, J., Barrows, L. R., Ireland, C. M. 1995. Topoisomerase II-Mediated DNA Cleavage by Adocia- and Xestoquinones From the Philippine Sponge Xestospongia sp. J Med Chem, 38: 4503-4507.
14-METHOXYXESTOQUINONE IC90=143 uM Concepcion, G. P., Foderaro, T. A., Eldredge, G. S., Lobkovsky, E., Clardy, J., Barrows, L. R., Ireland, C. M. 1995. Topoisomerase II-Mediated DNA Cleavage by Adocia- and Xestoquinones From the Philippine Sponge Xestospongia sp. J Med Chem, 38: 4503-4507.
15-CHLORO-14-HYDROXYXESTOQUINONE IC90=135 uM Concepcion, G. P., Foderaro, T. A., Eldredge, G. S., Lobkovsky, E., Clardy, J., Barrows, L. R., Ireland, C. M. 1995. Topoisomerase II-Mediated DNA Cleavage by Adocia- and Xestoquinones From the Philippine Sponge Xestospongia sp. J Med Chem, 38: 4503-4507.
15-METHOXYXESTOQUINONE IC90=143 uM Concepcion, G. P., Foderaro, T. A., Eldredge, G. S., Lobkovsky, E., Clardy, J., Barrows, L. R., Ireland, C. M. 1995. Topoisomerase II-Mediated DNA Cleavage by Adocia- and Xestoquinones From the Philippine Sponge Xestospongia sp. J Med Chem, 38: 4503-4507.
2',3,5-TRI-O-GALLOYL-HAMAMELOSE IC100=0.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
2,3-HEXAHYDROXYDIPHENOYL-D-GLUCOSE IC100=100 mM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
3',4'-DIDEMETHYL-EPIPODOPHYLLOTOXIN 0.4 mM *
3,4,5-TRI-O-GALLOYL-QUINIC-ACID IC100=0.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
3,5-DI-O-GALLOYLSHIKIMIC-ACID IC100=5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
3-O-GALLOYLSHIKIMIC-ACID IC100=5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
4'-DEMETHYL-EPIPODOPHYLLOTOXIN 100 uM Lee, K. H., et al. 1989. Antitumor Agents. 107. New Cytotoxic 4-alkylamino Analogues of 4'-demethyl-epipodophyllotoxin as Inhibitors of Human DNA Topoisomerase II. J Natural Products, 52: 606-613.
4'-DEMETHYLPODOPHYLLOTOXIN 100 uM Lee, K. H., et al. 1989. Antitumor Agents. 107. New Cytotoxic 4-alkylamino Analogues of 4'-demethyl-epipodophyllotoxin as Inhibitors of Human DNA Topoisomerase II. J Natural Products, 52: 606-613.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Abelmoschus esculentus Okra 2 70
Abelmoschus moschatus Ambrette; Musk Okra; Tropical Jewel Hibiscus; Muskmallow 2 0
Abies balsamea Balsam Fir 1 0
Abutilon theophrasti Velvet Leaf; Butterprint; Indian-Mallow; Abutilon-Hemp 3 0
Acacia catechu Black Cutch; Catechu 4 0
Acacia decurrens Green Wattle 1 0
Acacia farnesiana Cassie; Huisache; Sweet Acacia; Opopanax; Popinac 2 0
Acacia lenticularis 1 46.599998474121094
Acacia leucophloea Pilang Bast 1 0
Acacia modesta 1 0
Acacia nilotica Babul 3 0
Acacia senegal Gum Arabic; Gum Arabic Tree; Kher; Senegal Gum; Sudan Gum Arabic 3 0
Acacia tortilis Umbrella Thorn 1 0
Acalypha indica Cancer Herb; Indian Acalypha; Copperleaf; Indian Nettle; Three-Seeded-Mercury 1 0
Acanthus ilicifolius 1 0
Achillea millefolium Yarrow; Milfoil 3 0
Acinos suaveolens 4 1, 376.4999980926514
Acinos thymoides 1 500
Acrotrema arnottianum 1 650
Actinidia chinensis Kiwi 1 0