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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
  1. Home
  2. GENISTEIN

GENISTEIN

Chemical ID
GENISTEIN
Ubiquitous
No
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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Dosage Reference
NADH-Ubiquinone-Oxidoreductase-Inhibitor *
Natriuretic *
Ornithine-Decarboxylase-Inhibitor *
Peroxidase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Pesticide *
Phytoalexin Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.
Pituitary-sensitizer Medline (post 1990 searches filed in my computer)
PTK-Inhibitor 10-100 uM *
Quinone-Reductase-Inducer IC50=4.6 ug/ml *
Topoisomerase-I-Inhibitor IC50=250 ppm *
Topoisomerase-I-Inhibitor 1-10 ug/ml Okura, A., Arakawa, H., Oka, H., Yoshinari, T., Monden, Y. 1988. Effect of Genistein on Topoisomerase Activity and on the Growth of [VAL 12]HA-RAS-Transformed NIH 3T3 Cells. Biochem Biophys Res Commun, 157: 183-189.
Topoisomerase-II-Inhibitor IC50=1-150 uM *
Topoisomerase-II-Inhibitor 2-7.5 ug/ml *
Topoisomerase-II-Inhibitor IC50=30 ug/ml Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225.
Topoisomerase-II-Inhibitor 20 uM Markovits, J., et al. 1989. Inhibitory Effects of the Tyrosine Kinase Inhibitor Genistein on Mammalian DNA Topoisomerase II. Cancer Research, 49: 5111-5117.
Topoisomerase-II-Poison Journal of Medicinal Food 2: 167.1999.
Trypanosomastat Medline (post 1990 searches filed in my computer)
Tyrosine-Kinase-Inhibitor *
Uterotrophic EC50=0.1-25 uM/l *
Uterotrophic ED50=0.5 mg/kg *
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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name Plant Part Low Parts Per Million High Parts Per Million Standard Deviation Reference
Macrotyloma axillare Leaf Diffusate *
Macrotyloma uniflora Leaf *
Medicago sativa Leaf *
Medicago sativa Plant *
Medicago sativa Shoot *
Moghania macrophylla Wood *
Mucuna deeringiana Hypocotyl *
Mucuna pruriens Leaf Diffusate 8.0 -0.3 *
Mucuna pruriens Leaf Diffusate 6.0 -0.5 *
Neonotonia wightii Leaf Diffusate 5.0 -0.6 *
Ononis spinosa Root 17.0 38.0 1.0 *
Pericopsis laxiflora Fruit *
Phaseolus coccineus Plant J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991.
Phaseolus coccineus Plant *
Phaseolus lunatus Leaf Diffusate *
Phaseolus lunatus Leaf 2300.0 -0.6 Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.
Phaseolus lunatus Seed 0.0 40.1 -0.3 *
Phaseolus spp Plant *
Phaseolus vulgaris Fruit *
Phaseolus vulgaris Seed 17.7 45.1 -0.3 Kaufman,PB,Duke,JA,Brielmann,H,Boik,J and Hoyt,JE. 1997. A Comparative Survey of Leguminous Plants as Sources of the Isoflavones Genistein and Daidzein: Implications For Human Nutrition and Health. Journal of Alternative & Complementary Medicine 3(1):7-12