An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
  1. Home
  2. COLCHICINE

COLCHICINE

Chemical ID
COLCHICINE
Ubiquitous
No
List of known dosages
Dosage Reference
LD50=1.6 (ivn rat)
LD50=4.13 (ivn mus) Merck 11th Edition
LDlo=0.186 (orl hmn) CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses
LDlo=7 mg/man Martindale's 29th
LD50=0.13 (orl cat) Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.
LD50=66.6 (orl mus) Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.

Select a Results View:

Download these results as:
CSV
EXCEL
PDF
List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Dosage Reference
Antipyretic *
Antirheumatic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Antisarcomic ED50=0.047 ug/ml J. Ethnopharmacology, 32: 117.
Antithrombocytopenic 600 ug/2-4x/man/day Martindale's 29th
Antitrypanosomic Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.
Antitubulin IC50=2.4 uM *
Antitumor (Breast) ED50=0.022 ug/ml J. Ethnopharmacology, 32: 117.
Antitumor (Colon) ED50=0.0071 ug/ml J. Ethnopharmacology, 32: 117.
Antitumor (Lung) ED50=0.043 ug/ml J. Ethnopharmacology, 32: 117.
Antivasculitic 600 ug/2x/man/day Martindale's 29th
Carcinogenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Cardioactive 15 mg/kg scu rbt Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.
CNS-Paralytic *
CNS-Stimulant *
Cytotoxic IC50=0.018 uM *
Emetic Cooper-Driver, G. A., Chemical substances in plants toxic to animals, pp. 213-47 in Rechcigl, M., Jr., ed. CRC Handbook of Naturally Occurring Food Toxicants, CRC Press, Boca Raton, 1983, 339 pp.
Hepatoprotective *
Hypertensive *
Irritant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Pesticide *
Download these results as:
CSV
EXCEL
PDF
List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name Plant Part Low Parts Per Million High Parts Per Million Standard Deviation Reference
Colchicum autumnale Tuber 800.0 12300.0 *
Gloriosa superba Bulb *