Scrophularia scorodonia | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Activities: 88

Chemicals w/Activities: 16

All Chemicals: 28

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
0	6-METHOXYCATALPOL	Root	--	55.0	--	De Sandos, J., Fernandez, L., Diaz, A. M., Rubio, B., Ollivier, E., Faure, R., Balansard, G. 1998. Catalpol Glycosides from Scrophularia scorodonia. Pharmazie, 53(6): 427-428.
0	6-O-ALPHA-L-[3''-O-TRANS-P-COUMAROYL]-RHAMNOPYRANOSYLCATALPOL	Flower	--	27.0	--	De Sandos, J., Fernandez, L., Diaz, A. M., Rubio, B., Ollivier, E., Faure, R., Balansard, G. 1998. Catalpol Glycosides from Scrophularia scorodonia. Pharmazie, 53(6): 427-428.
1	8-ACETYLHARPAGIDE	Plant	--	--	--	Benito, P. B., Lanza, A. M. D., Sen, A. M. S., Galindez, J. D., Matellano, L. F., Gomez, A. S., Martinez, M. J. A. 2000. Effects of some iridoids from plant origin on arachidonic acid metabolism in cellular systems. Planta Medica, 66(4): 324-328.
Antiinflammatory IC50=19.5 uM Benito, P. B., Lanza, A. M. D., Sen, A. M. S., Galindez, J. D., Matellano, L. F., Gomez, A. S., Martinez, M. J. A. 2000. Effects of some iridoids from plant origin on arachidonic acid metabolism in cellular systems. Planta Medica, 66(4): 324-328.
1	8-O-ACETYLHARPAGIDE	Plant	--	--	--	Fernandez, L., Martin, T., Villaescusa, L., Bartolome, C., Rubio, B., Diaz, A. M. 1995. Rosmarinic Acid and Iridoids of Scrophularia scorodonia L. Colloq Inst Natl Rech Agron, 69: 307-308.
Cytotoxic ED50=>200-425 uM *
1	8-O-ACETYLHARPAGIDE	Leaf	--	0.0	--	Fernandez-Matellano, L., Ollivier, E., Diaz-Lanza, A. M., Faure, R., Balansard, G. 1995. Iridoids from Scrophularia scorodonia. Planta Medica, 61(1): 93.
Cytotoxic ED50=>200-425 uM *
0	8-O-CIS-CINNAMOYLHARPAGIDE	Shoot	--	0.0	--	Fernandez, L., Diaz, A. M., Ollivier, E., Faure, R., Balansard, G. 1995. An Iridoid Diglycoside Isolated from Scrophularia scorodonia. Phytochemistry, 40(5): 1569-1571.
20	AUCUBIN	Plant	--	--	--	Benito, P. B., Lanza, A. M. D., Sen, A. M. S., Galindez, J. D., Matellano, L. F., Gomez, A. S., Martinez, M. J. A. 2000. Effects of some iridoids from plant origin on arachidonic acid metabolism in cellular systems. Planta Medica, 66(4): 324-328.
Antibacterial * Antidote (Amanitin) 200 mg/kg ipr mus Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 276. Antiedemic 1/2 indomethacin Bruneton, J. 1999. Pharmacognosy, Phytochemistry, Medicinal Plants. 2nd Ed. Lavoisier Publishing, Paris. 1119 pp. Antiinflammatory 1/2 indomethacin * Antiinflammatory IC50=12-72 uM * Antileukemic IC50=25-56 ug/ml Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antioxidant * Antiprolactin * Antistaphylococcic * Candidicide * Cathartic ED50=390 mg/kg Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176) Collagenic * Diuretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Hepatoprotective * Lactagogue Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Laxative Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Paralytic Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Pesticide * RNA-Inhibitor Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 275. Uricosuric Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
0	AUCUBOSIDE	Leaf	--	35.0	--	Fernandez-Matellano, L., Ollivier, E., Diaz-Lanza, A. M., Faure, R., Balansard, G. 1995. Iridoids from Scrophularia scorodonia. Planta Medica, 61(1): 93.
1	BARTSIOSIDE	Plant	--	--	--	Benito, P. B., Lanza, A. M. D., Sen, A. M. S., Galindez, J. D., Matellano, L. F., Gomez, A. S., Martinez, M. J. A. 2000. Effects of some iridoids from plant origin on arachidonic acid metabolism in cellular systems. Planta Medica, 66(4): 324-328.
Antiinflammatory IC50=4.3 uM Benito, P. B., Lanza, A. M. D., Sen, A. M. S., Galindez, J. D., Matellano, L. F., Gomez, A. S., Martinez, M. J. A. 2000. Effects of some iridoids from plant origin on arachidonic acid metabolism in cellular systems. Planta Medica, 66(4): 324-328.
1	BARTSIOSIDE	Leaf	--	30.0	--	Fernandez-Matellano, L., Ollivier, E., Diaz-Lanza, A. M., Faure, R., Balansard, G. 1995. Iridoids from Scrophularia scorodonia. Planta Medica, 61(1): 93.
Antiinflammatory IC50=4.3 uM Benito, P. B., Lanza, A. M. D., Sen, A. M. S., Galindez, J. D., Matellano, L. F., Gomez, A. S., Martinez, M. J. A. 2000. Effects of some iridoids from plant origin on arachidonic acid metabolism in cellular systems. Planta Medica, 66(4): 324-328.
0	BUDDLEJASAPONIN	Flower	--	4000.0	--	Emam, A. M., Diaz-Lanza, A. M., Matellano-Fernandez, L., Faure, R., Moussa, A. M. Balansard, G. 1997. Biological Activities of Buddlejasaponin Isolated from Buddleja madagascarienis and Scrophularia scorodonia. Pharmazie, 52(1): 76-77.
6	HARPAGIDE	Plant	--	--	--	Benito, P. B., Lanza, A. M. D., Sen, A. M. S., Galindez, J. D., Matellano, L. F., Gomez, A. S., Martinez, M. J. A. 2000. Effects of some iridoids from plant origin on arachidonic acid metabolism in cellular systems. Planta Medica, 66(4): 324-328.
(-)-Chronotropic * (-)-Inotropic * Analgesic * Antiarthritic * Antiinflammatory Planta Medica, 55(7): 626. Calcium-Antagonist Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp.
6	HARPAGOSIDE	Plant	--	--	--	*
(+)-Inotropic * (-)-Chronotropic * Analgesic Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176) Antiarrhythmic Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Antiinflammatory IC50=10 uM * Calcium-Antagonist Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp.
6	HARPAGOSIDE	Leaf	--	2072.0	--	*
(+)-Inotropic * (-)-Chronotropic * Analgesic Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176) Antiarrhythmic Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Antiinflammatory IC50=10 uM * Calcium-Antagonist Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp.
6	HARPAGOSIDE	Stem	--	--	--	Diaz, A., et al. 1998. Reverse-Phase High Pressure Liquid Chromatographic Analysis of Harpagoside, Scorodioside and Verbascoside from Scrophularia scorodonia: Quantitative Determination of Harpagoside. Planta Medica, 64(1): 94-95.
(+)-Inotropic * (-)-Chronotropic * Analgesic Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176) Antiarrhythmic Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Antiinflammatory IC50=10 uM * Calcium-Antagonist Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp.
6	HARPAGOSIDE	Flower	--	--	--	Diaz, A., et al. 1998. Reverse-Phase High Pressure Liquid Chromatographic Analysis of Harpagoside, Scorodioside and Verbascoside from Scrophularia scorodonia: Quantitative Determination of Harpagoside. Planta Medica, 64(1): 94-95.
(+)-Inotropic * (-)-Chronotropic * Analgesic Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176) Antiarrhythmic Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Antiinflammatory IC50=10 uM * Calcium-Antagonist Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp.
57	ROSMARINIC-ACID	Plant	--	--	--	Fernandez, L., Martin, T., Villaescusa, L., Bartolome, C., Rubio, B., Diaz, A. M. 1995. Rosmarinic Acid and Iridoids of Scrophularia scorodonia L. Colloq Inst Natl Rech Agron, 69: 307-308.
ABeta-Inhibitor * Adenylate-Cyclase-Inhibitor * Aldose-Reductase-Inhibitor * Antiaggregant Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Antiallergic * Antialzheimeran * Antianaphylactic 1-100 mg/kg orl Int. J. Immunopharmacology. Vol 10: 729, 1988. Antianaphylactic ID50=1 mg/kg ivn rat * Antianaphylactic ID50=10 mg/kg ims rat * Antiatherosclerotic IC50=0.74 uM * Antibacterial Planta Medica, 55: 663. Anticoagulant Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Anticomplementary 20 mg/kg ivn Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Anticomplementary 1/2 aspirin * Antidepressant * Antiedemic 0.316-3.16 mg/kg ims Int. J. Immunopharmacology. Vol 10: 729, 1988. Antigonadotropic * Antihemolytic IC70=5-10 um/l Int. J. Immunopharmacology. Vol 10: 729, 1988. Antihepatotoxic * Antiherpetic EC50=20 ug/ml * Antiherpetic 50 ug/ml Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. AntiHIV EC50=40 ug/ml * Antihyperthyroid * Antiinflammatory IC~58=1,000 uM * Antiintegrase 10 ug/ml * Antileukotriene * Antilipoperoxidant * Antimutagenic * Antinephritic * Antioxidant 10 uM * Antioxidant EC50=2.7 ug/ml Parveen, N. 1991. Antifilarial Activity of Vitex negundo Against Setaria cervi. Fitoterapia, 62(2): 163, 1991. Antioxidant (LDL) IC50=0.74 uM * Antiplaque * Antiproliferant * Antiprostaglandin 20 mg/kg ivn Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antiproteolytic IC50=0.9 mol l Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Antipulmonotic Tyler, V.E.. 1994. Antiradicular * Antishock Int. J. Immunopharmacology. Vol 10: 735, 1988. Antithyreotropic * Antithyroid Jim Duke's personal files. Antiuremic * Antiviral EC50=40 ug/ml * Anxiolytic * Apoptotic * Calcium-Antagonist IC50=1.2 uM rbt * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. COX-1-Inhibitor IC58=1,000 uM * COX-2-Inhibitor IC>58=1,000 uM * Cytotoxic TC50=100-150 ug/ml * Deiodinase-Inhibitor Jim Duke's personal files. Immunomodulator * Immunostimulant * Lipoxygenase-Inhibitor * Neuroprotective * Pesticide * Radioprotective *
0	SACCATOSIDE	Flower	--	29.0	--	De Sandos, J., Fernandez, L., Diaz, A. M., Rubio, B., Ollivier, E., Faure, R., Balansard, G. 1998. Catalpol Glycosides from Scrophularia scorodonia. Pharmazie, 53(6): 427-428.
0	SCORODIOSIDE	Leaf	--	--	--	Diaz, A., et al. 1998. Reverse-Phase High Pressure Liquid Chromatographic Analysis of Harpagoside, Scorodioside and Verbascoside from Scrophularia scorodonia: Quantitative Determination of Harpagoside. Planta Medica, 64(1): 94-95.
0	SCORODIOSIDE	Stem	--	--	--	Diaz, A., et al. 1998. Reverse-Phase High Pressure Liquid Chromatographic Analysis of Harpagoside, Scorodioside and Verbascoside from Scrophularia scorodonia: Quantitative Determination of Harpagoside. Planta Medica, 64(1): 94-95.

List of all activity chemical
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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Scrophularia scorodonia (Scrophulariaceae)

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