Cinchona officinalis | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Lojabark, Quinine

How used

Medicinal

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Activities: 80

Chemicals w/Activities: 9

All Chemicals: 9

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List of all chemical
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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
3	3-ALPHA,17-BETA-CINCHOPHYLLINE	Leaf	--	--	--	*
Amebicide IC50=3.50 ug/ml Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Cytotoxic IC50=0.4 ug/ml Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Pesticide *
3	3-BETA,17-BETA-CINCHOPHYLLINE	Leaf	--	--	--	*
Amebicide IC50=1.62 ug/ml Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Cytotoxic IC50=2.24 ug/ml Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Pesticide *
7	AVICULARIN	Leaf	--	--	--	*
Aldose-Reductase-Inhibitor IC32=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888. Aldose-Reductase-Inhibitor IC84=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888. Antibiotic CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses Cyclooxygenase-Activator 100 uM Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Diuretic CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses Pesticide * Tissue-Thromboplastin-Inhibitor IC50=54.8 uM *
6	CINCHONIDINE	Bark	--	--	--	*
Antiflu * Antiherpetic * Antimalarial 150-500 mg/man/4 x day * Antipyretic =ICMR(Indian Council of Medical Research).1976.Medicinal Plants of India.Vol.1.Indian Council of Med. Res.Cambridge Printing Works, New Delhi.487 pp;ICMR.1987.Medicinal Plants of India.Vol.2.Indian Council of Med. Res.Cambr. Printing Works,New Delhi.600pp Antiviral * Pesticide *
7	CINCHONINE	Bark	--	--	--	*
Antiaggregant IC50=125-180 uM * Antimalarial LD50=152 (ipr rat) Merck 11th Edition Antipyretic =ICMR(Indian Council of Medical Research).1976.Medicinal Plants of India.Vol.1.Indian Council of Med. Res.Cambridge Printing Works, New Delhi.487 pp;ICMR.1987.Medicinal Plants of India.Vol.2.Indian Council of Med. Res.Cambr. Printing Works,New Delhi.600pp MDR-Inhibitor 250 mg/kg igs rat Genne, P., Duchamp, O., Solary, E., Magnette, J., Belon, J. P., Chauffert, B. 1995. Cinchonine Per OS: Efficient Circumvention of P-Glycoprotein-Mediated Multidrug Resistance. Anticancer Drug Design, 10(2): 103-118. MDR-Inhibitor 5 uM * PAF-Inhibitor IC50=125-180 uM * Pesticide *
3	HYDROQUINIDINE	Bark	--	--	--	Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antiarrhythmic 450-600 mg/man/day Martindale's 29th Antimalarial Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide *
23	QUINIDINE	Bark	--	--	--	*
Abortifacient * Allergenic * Amebicide IC50=16.6 ug/ml Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Analgesic Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Antiarrhythmic ED50=60 uM/kg Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Antiarrhythmic 72 mg/kg ipr mus * Anticholinergic Martindale's 28th Antihiccup * Antimalarial 10 mg/kg/orl/man/8 hrs Martindale's 29th Antipyretic =ICMR(Indian Council of Medical Research).1976.Medicinal Plants of India.Vol.1.Indian Council of Med. Res.Cambridge Printing Works, New Delhi.487 pp;ICMR.1987.Medicinal Plants of India.Vol.2.Indian Council of Med. Res.Cambr. Printing Works,New Delhi.600pp Antitachycardic * Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Cardiodepressant Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Dermatitigenic * Emetic * Hemolytic Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Hypotensive Martindale's 29th Immunosuppressant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Laxative Martindale's 29th MDR-Inhibitor 100 uM Critchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445. MDR-Inhibitor IC50=1-12 uM * Myorelaxant Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Oxytocic *
32	QUININE	Bark	--	--	--	*
Abortifacient * Allergenic * Amebicide IC50=14.8 ug/ml * Analgesic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Anesthetic Wealth of India. Antibacterial * Antidysenteric * Antifeedant * Antifibrillary Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antihemorrhoidal Wealth of India. Antilumbagic Wealth of India. Antimalarial IC50=0.18 ug/ml Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Antineuralgic Wealth of India. Antineuritic Wealth of India. Antipyretic Merck 11th Edition Antisciatic Wealth of India. Antitrypanosomic * Antiyeast * Apertif * Astringent * Cardiodepressant Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Cytotoxic IC50=183 ug/ml Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Dermatitigenic * FLavor FEMA 5-83 (-100) Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry MDR-Inhibitor IC50=4-17 uM * Oxytocic * Pesticide * Phototoxic * Protisticide * Spermicide Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Stomachic Merck 11th Edition Trypanocide *
35	TANNIN	Bark	--	--	--	*
Anthelmintic * Antibacterial * Anticancer * Anticariogenic * Antidiarrheic * Antidysenteric * Antihepatotoxic * AntiHIV * Antihypertensive * Antilipolytic * Antimutagenic * Antinephritic Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990. Antiophidic Economic & Medicinal Plant Research, 5: 363. Antioxidant 1/3 quercetin * Antioxidant IC50=1.44 ug/ml * Antiradicular 1/3 quercetin * Antiradicular 500 mg/kg/day orl mus Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990. Antirenitic Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990. Antitumor * Antitumor-Promoter * Antiulcer * Antiviral * Cancer-Preventive HerbalGram No. 22 - Spring 1990, page 14. Carcinogenic * Chelator * Cyclooxygenase-Inhibitor * Glucosyl-Transferase-Inhibitor * Hepatoprotective * Immunosuppressant * Lipoxygenase-Inhibitor * MAO-Inhibitor * Ornithine-Decarboxylase-Inhibitor * Pesticide * Psychotropic Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990. Xanthine-Oxidase-Inhibitor *

^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Cinchona officinalis (Rubiaceae)

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