Uncaria tomentosa | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Cat's Claw, Garabato Amarillo, Una de Gato

How used

Medicinal

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Activities: 246

Chemicals w/Activities: 58

All Chemicals: 97

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Exclude ubiquitous chemicals - View the list of ubiquitous chemicals

List of all chemical
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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
38	(-)-EPICATECHIN	Bark	--	25.0	1.00	*
5-Lipoxygenase-Inhibitor IC50=22-50 uM/l * ACE-Inhibitor IC50=0.216 mM/l * ACE-Inhibitor 0.5 mg/ml rbt (weak activity) * Allelochemic Hanke, F. J., Natural Products as a Resource for Biologically Active Compounds, Thesis, U. Cal (Santa Cruz), 1986, 252 pp Antiaggregant * Antianaphylactic * Antibacterial * Antidiabetic 30 mg/kg rat * AntiEBV Economic & Medicinal Plant Research, 6: 189. Antihepatitic Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. AntiHIV EC50=2 ug/ml * Antihyperglycemic * Antiinflammatory * Antileukemic Economic & Medicinal Plant Research, 6: 189. Antileukotriene * Antilipoperoxidant * Antimutagenic * Antioxidant IC50=6.3 ug/ml * Antiperoxidant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral EC50=2 ug/ml * Beta-Adrenergic Receptor Blocker 10 uM Zhu, M., Phillipson, J. D., Greengrass, P. M., Bowery, N. E., Cai, Y. 1997. Plant Polyphenols: Biologically Active Compounds or Non-Selective Binders to Protein? Phytochemistry, 44(3): 441-447. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardiotonic * Choline-Sparing * COMP-Inhibitor Dullo, A. G., et al. 1999. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am. J. Clinical Nutrition, 70: 1040-1045. Cytotoxic TC50=>100 ug/ml * Hypocholesterolemic * Hypoglycemic * Immunostimulant * Insulinogenic Economic & Medicinal Plant Research, 6: 170. Lipoxygenase-1-Inhibitor IC50=60 mM * Lipoxygenase-Inhibitor IC50=140 uM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Lipoxygenase-Inhibitor IC97=5 mM Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690. Pancreatogenic * Pesticide * Reverse-Transcriptase-Inhibitor 10 ng/ml McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Vasodilator uM McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Xanthine-Oxidase-Inhibitor IC50=>40 Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
0	16-ALPHA-HYDROXY-3-BETA-METHOXY-URSA-12,19(29)-DIEN-27,28-DIOIC-ACID	Root Bark	--	8.0	--	*
0	27-O-BETA-D-GLUCOPYRANOSIDE-QUINOVIC-ACID	Root Bark	--	9.0	--	*
0	3-BETA-6-BETA-19-ALPHA-TRIHYDROXY-23-OXO-URS-12-EN-28-OIC ACID	Bark	--	57.4	--	*
0	3-BETA-6-BETA-19-ALPHA-TRIHYDROXY-URS-12-ENE-23-28-DIOIC ACID	Root Bark	--	8.0	--	*
0	3-BETA-HYDROXY-3-OXO-URS-12-EN-27,28-DIOIC-ACID	Root Bark	--	--	--	*
0	3BETA,6BETA,19ALPHA-TRIHYDROXY-URS-12-EN-28-OIC-ACID	Root Bark	197.0	250.0	--	*
0	3BETA,6BETA,19ALPHA-TRIHYDROXY-URS-12-EN-28-OIC-ACID	Plant	--	--	--	*
0	3BETA,6BETA,19ALPHA-TRIHYDROXY-URS-12-EN-28-OIC-ACID	Bark	--	65.0	--	*
0	5ALPHA-CARBOXYSTRICTOSIDINE	Root Bark	--	255.0	--	*
0	5ALPHA-CARBOXYSTRICTOSIDINE	Plant	--	--	--	*
0	6-BETA-19-ALPHA-DIHYDROXY-3-OXO-URS-12-EN-28-OIC-ACID	Root Bark	--	0.0	--	*
3	AKUAMMIGINE	Leaf	--	9200.0	--	*
Adrenolytic Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Antimalarial * Sympatholytic Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
3	AKUAMMIGINE	Root	--	300.0	--	*
Adrenolytic Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Antimalarial * Sympatholytic Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
1	ALLOISOPTEROPODINE	Root	--	--	--	*
Immunostimulant *
1	ALLOPTEROPODINE	Root	--	--	--	*
Immunostimulant *
1	ANGUSTINE	Leaf	--	--	--	*
Toxic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
47	BETA-SITOSTEROL	Bark	--	--	--	*
Androgenic * Angiogenic * Anorexic Martindale's 28th Antiadenomic Merck 11th Edition Antiandrogenic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antibacterial Recently became Internat. J. Crude Drug Res. 28(1,2,3,4):1990, page 155. Anticancer (Breast) Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103. Anticancer (Cervix) * Anticancer (Lung) * Antiedemic IC54=320 mg/kg orl * Antiestrogenic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antifeedant Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Antifertility Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antigonadotrophic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antihyperlipoproteinaemic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiinflammatory * Antileukemic * Antilymphomic * Antimutagenic 250 ug/ml * Antiophidic 2.3 mg mus Economic & Medicinal Plant Research, 5: 363. Antioxidant IC44=10 uM * Antiprogestational Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antiprostaglandin 30 mg/day/12 wks * Antiprostatadenomic Merck 11th Edition Antiprostatitic 10-20 mg 3 x/day/orl man * Antipyretic Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Antitumor (Breast) Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103. Antitumor (Cervix) * Antitumor (Lung) * Antiviral Abid Ali Khan, M.M., Jain, D.C., Bhakuni, R.S., Zaim, M., and Thakur, R.S. 1991. Occurrence of some antiviral sterols in Artemisia annua. Plant Science, 75: 161-165, 1991. Apoptotic * Artemicide LC50=110 ppm Jung, J.H., Pummangura, S., Chaichantipyuth, c., Patarapanich, C., and McLaughlin, J.L. 1989. Bioactive Constituents of Melodorum fruticosum. Phytochemistry. 29(5): 1667-1670. 1990. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidicide Recently became Internat. J. Crude Drug Res. 28(1,2,3,4):1990, page 155. Caspase-8-Inducer * Estrogenic * Febrifuge Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Gonadotrophic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Hepatoprotective * Hypocholesterolemic 2-6 g/man/day/orl Martindale's 30th Hypocholesterolemic 9-3,330 mg/man/day/orl Martindale's 28th Hypoglycemic Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989. Hypolipidemic 2-6 g/day * Pesticide * Spermicide Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Ubiquiot Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Ulcerogenic 500 mg/kg ipr rat *
2	CAMPESTEROL	Bark	--	--	--	*
Antioxidant IC37=10 uM * Hypocholesterolemic Duke, J. A. Writeups or information summaries on approximately 2,000 economic plants, USDA, ARS, Beltsville, MD 20705.
77	CHLOROGENIC-ACID	Bark	--	--	--	Van Ginkel, A. 1996. Identification of the Alkaloids and Flavonoids from Uncaria tomentosa Bark by TLC in Quality Control. Phytotherapy Research, 10: S18-S19.
Aldose-Reductase-Inhibitor IC50=1.8 uM rat (strong activity) Yoshikawa, M., et al. 1999. Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, From the Flowers of Chrysanthemum inducum L. Chem Pharm Bull, 47(3): 340-345. Allelochemic * Allergenic * Analgesic * Antiatherosclerotic * Antibacterial * Anticancer (Colon) * Anticancer (Forestomach) * Anticancer (Liver) * Anticancer (Skin) * Anticarcinogenic * Antidiabetic * AntiEBV Economic & Medicinal Plant Research, 6: 189. Antifeedant * Antigenotoxic * Antigonadotropic Jim Duke's personal files. Antihemolytic 10 uM Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., and Kido, R. 1993. Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. Phytochemistry. 36(3): 579-583. 1994. Antihepatotoxic * Antiherpetic Economic & Medicinal Plant Research, 5: 194. Antihistaminic * AntiHIV Economic & Medicinal Plant Research, 6: 189. Antihypercholesterolemic Economic & Medicinal Plant Research, 6: 189. Antihyperthyroid * Antiinflammatory Hagerman, A.E. Tannin-Protein Interactions. Phenolic Compounds in Food and Their Effects on Health, Ch.19. AntiLegionella * Antileukotriene * Antimelanogenic * Antimutagenic * Antinitrosaminic * Antioxidant IC53=200 ppm Huang, M-T., and Ferraro, T. Phenolic Compounds in Food and Cancer Prevention. Phenolic Compounds in Food and Their Effects on Health, Ch.2 p.21. Antioxidant IC80=12 uM * Antioxidant IC50=54.2 uM * Antiperoxidant IC50=36 uM Planta Medica, 57: A54, 1991. Antipolio Jim Duke's personal files. Antiradicular 10 uM Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., and Kido, R. 1993. Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. Phytochemistry. 36(3): 579-583. 1994. Antiradicular 9 x quercetin * Antiseptic * Antisunburn * Antithyroid Jim Duke's personal files. Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antitumor (Colon) * Antitumor (Forestomach) * Antitumor (Liver) * Antitumor (Skin) * Antitumor-Promoter IC25=10 uM * Antiulcer Economic & Medicinal Plant Research, 6: 189. Antiviral Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Autotoxic * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardioprotective * Chemopreventive * Cholagogue Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Choleretic Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Clastogenic Friedman, M. and Dao, L. 1990. Effect of Autoclaving and Conventional and Microwave Baking on the Ergot Alkaloid and Chlorogenic Acid Contents of Morning Glory (Ipomoea tricolor Cav. cv.) Heavenly Blue Seeds. J. Agric. Food Chem. 38: 805-808. CNS-Active Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. CNS-Stimulant 1/6 Caffeine * Collagen-Sparing * Diuretic * Fungicide Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Hepatoprotective Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Histamine-Inhibitor * Hypoglycemic * Immunostimulant * Insectifuge Tunon, H., Thorsell, W., and Bohlin, L. 1993. Mosquito Repelling Activity of Compounds Occurring in Achillea millefolium L. (Asteraceae). Economic Botany 48(2): 111-120, 1994. Interferonogenic Economic & Medicinal Plant Research, 1: 124. Juvabional Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Larvistat Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Leukotriene-Inhibitor * Lipoxygenase-Inhibitor IC23=5 mM Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690. Metal-Chelator McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. NO-Genic * Ornithine-Decarboxylase-Inhibitor Hagerman, A.E. Tannin-Protein Interactions. Phenolic Compounds in Food and Their Effects on Health, Ch.19. Oviposition-Stimulant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide * Sunscreen * Sweetener Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Vulnerary *

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Uncaria tomentosa (Pedaliaceae)

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