Rheum officinale | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Chinese Rhubarb

How used

Medicinal

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Activities: 313

Chemicals w/Activities: 45

All Chemicals: 114

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
30	(+)-CATECHIN	Rhizome	--	3628.6	-1.00	*
ACE-Inhibitor 0.24 mg/ml rbt (weak activity) * ACE-Inhibitor IC50=0.155 mM/l * Antiaggregant IC68=200 ug/ml * Anticoagulant * Anticomplementary 1/2 aspirin * AntiHIV EC50=4 ug/ml * Antiinflammatory IC50=40-943 uM (cf indomethacin IC50=1 uM) * Antimutagenic ID50=50-100 nM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antioxidant * Antiperoxidant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiprostaglandin IC50=40-943 uM (cf indomethacin IC50=1 uM) * Antiradicular Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiulcer * Beta-Adrenergic Receptor Blocker 10 uM (weak activity) Zhu, M., Phillipson, J. D., Greengrass, P. M., Bowery, N. E., Cai, Y. 1997. Plant Polyphenols: Biologically Active Compounds or Non-Selective Binders to Protein? Phytochemistry, 44(3): 441-447. cAMP-Phosphodiesterase-Inhibitor * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardiotonic * COX-1-Inhibitor IC50=183-279 uM (cf indomethacin IC50=1 uM) * COX-2-Inhibitor IC50=546-5,910 uM (cf indomethacin IC50=1 uM) * Cyclooxygenase-Inhibitor * Cytotoxic TC50=>100 ug/ml * Dermatitigenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Hemostat Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Hepatoprotective Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Immunostimulant Economic & Medicinal Plant Research, 1: 124. Neuroprotective 1-10 uM * NO-Inhibitor IC11=250 uM * Phagocytotic Economic & Medicinal Plant Research, 1: 124. Vasoconstrictor Leung, A.Y., Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, John Wiley & Sons, New York, 1980. Xanthine-Oxidase-Inhibitor Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
30	(+)-CATECHIN	Plant	--	--	--	*
ACE-Inhibitor 0.24 mg/ml rbt (weak activity) * ACE-Inhibitor IC50=0.155 mM/l * Antiaggregant IC68=200 ug/ml * Anticoagulant * Anticomplementary 1/2 aspirin * AntiHIV EC50=4 ug/ml * Antiinflammatory IC50=40-943 uM (cf indomethacin IC50=1 uM) * Antimutagenic ID50=50-100 nM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antioxidant * Antiperoxidant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiprostaglandin IC50=40-943 uM (cf indomethacin IC50=1 uM) * Antiradicular Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiulcer * Beta-Adrenergic Receptor Blocker 10 uM (weak activity) Zhu, M., Phillipson, J. D., Greengrass, P. M., Bowery, N. E., Cai, Y. 1997. Plant Polyphenols: Biologically Active Compounds or Non-Selective Binders to Protein? Phytochemistry, 44(3): 441-447. cAMP-Phosphodiesterase-Inhibitor * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardiotonic * COX-1-Inhibitor IC50=183-279 uM (cf indomethacin IC50=1 uM) * COX-2-Inhibitor IC50=546-5,910 uM (cf indomethacin IC50=1 uM) * Cyclooxygenase-Inhibitor * Cytotoxic TC50=>100 ug/ml * Dermatitigenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Hemostat Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Hepatoprotective Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Immunostimulant Economic & Medicinal Plant Research, 1: 124. Neuroprotective 1-10 uM * NO-Inhibitor IC11=250 uM * Phagocytotic Economic & Medicinal Plant Research, 1: 124. Vasoconstrictor Leung, A.Y., Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, John Wiley & Sons, New York, 1980. Xanthine-Oxidase-Inhibitor Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
38	(-)-EPICATECHIN	Rhizome	--	3437.5	--	*
5-Lipoxygenase-Inhibitor IC50=22-50 uM/l * ACE-Inhibitor IC50=0.216 mM/l * ACE-Inhibitor 0.5 mg/ml rbt (weak activity) * Allelochemic Hanke, F. J., Natural Products as a Resource for Biologically Active Compounds, Thesis, U. Cal (Santa Cruz), 1986, 252 pp Antiaggregant * Antianaphylactic * Antibacterial * Antidiabetic 30 mg/kg rat * AntiEBV Economic & Medicinal Plant Research, 6: 189. Antihepatitic Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. AntiHIV EC50=2 ug/ml * Antihyperglycemic * Antiinflammatory * Antileukemic Economic & Medicinal Plant Research, 6: 189. Antileukotriene * Antilipoperoxidant * Antimutagenic * Antioxidant IC50=6.3 ug/ml * Antiperoxidant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral EC50=2 ug/ml * Beta-Adrenergic Receptor Blocker 10 uM Zhu, M., Phillipson, J. D., Greengrass, P. M., Bowery, N. E., Cai, Y. 1997. Plant Polyphenols: Biologically Active Compounds or Non-Selective Binders to Protein? Phytochemistry, 44(3): 441-447. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardiotonic * Choline-Sparing * COMP-Inhibitor Dullo, A. G., et al. 1999. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am. J. Clinical Nutrition, 70: 1040-1045. Cytotoxic TC50=>100 ug/ml * Hypocholesterolemic * Hypoglycemic * Immunostimulant * Insulinogenic Economic & Medicinal Plant Research, 6: 170. Lipoxygenase-1-Inhibitor IC50=60 mM * Lipoxygenase-Inhibitor IC50=140 uM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Lipoxygenase-Inhibitor IC97=5 mM Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690. Pancreatogenic * Pesticide * Reverse-Transcriptase-Inhibitor 10 ng/ml McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Vasodilator uM McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Xanthine-Oxidase-Inhibitor IC50=>40 Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
0	1,2,6-TRI-O-GALLOYL-GLUCOSE	Rhizome	--	365.7	--	*
0	1,8,6-TRIHYDROXY-3-METHYLANTHRAQUINONE	Plant	--	--	--	*
0	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE	Root	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
0	1,8-DIHYDROXY-3-HYDROXYMETHYLANTRHAQUINONE	Root	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
0	1,8-DIHYDROXY-3-METHYLANTHRAQUINONE	Plant	--	--	--	*
0	1,8-DIHYDROXY-6-METHOXY-3-METHYLANTHRAQUINONE	Root	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
0	1-O-GALLOYL-GLYCEROL	Plant	--	--	--	*
0	3,3'-DI-O-GALLOYLPROCYANIDIN-B-2	Rhizome	--	1514.3	--	*
0	3-O-GALLOYL-PROCYANIDIN-B-1	Rhizome	--	771.4	--	*
0	6-O-GALLOYL-GLUCOSE	Plant	--	--	--	*
24	ALOE-EMODIN	Rhizome	--	--	--	*
Antibacterial MIC=2-64 ug/ml * Antiherpetic * Antileukemic * Antisalmonella Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antiseptic MIC=2-64 ug/ml * Antistaphylococcic MIC=2-64 ug/ml * Antitumor 1 ug/mL * Antiviral * Arylamine-N-Acetyltransferase-Inhibitor * Calcium-Antagonist (strong activity) * Candidicide MIC=25-250 ug/ml * Cathartic Merck 11th Edition Cytotoxic 20 ppm * Estrogenic * Fungicide MIC=25-250 ug/ml * Genotoxic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Laxative * Mutagenic * Pesticide * Purgative ED50=>59.6 mg/kg orl mus * Termitifuge Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Topoisomerase-II-Inhibitor 1 mM Muller, S. O., Eckert, I., Lutz, W. K., Stopper, H. 1996. Genotoxicity of the Laxative Drug Components Emodin, Aloe-emodin and Danthron in Mammalian Cells: Topoisomerase II Mediated? Mutat Res, 371: 165-173. Topoisomerase-II-Inhibitor IC50=741 uM/ml Mueller, S. O., Stopper, H. 1999. Characterization of the Genotoxicity of Anthraquinones in Mammalian Cells. Biochimica & Biophysica Acta, 1428: 406-414. Tuberculostatic Pakistan Encyclopedia Planta Medica. 1986.
24	ALOE-EMODIN	Plant	--	--	--	*
Antibacterial MIC=2-64 ug/ml * Antiherpetic * Antileukemic * Antisalmonella Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antiseptic MIC=2-64 ug/ml * Antistaphylococcic MIC=2-64 ug/ml * Antitumor 1 ug/mL * Antiviral * Arylamine-N-Acetyltransferase-Inhibitor * Calcium-Antagonist (strong activity) * Candidicide MIC=25-250 ug/ml * Cathartic Merck 11th Edition Cytotoxic 20 ppm * Estrogenic * Fungicide MIC=25-250 ug/ml * Genotoxic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Laxative * Mutagenic * Pesticide * Purgative ED50=>59.6 mg/kg orl mus * Termitifuge Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Topoisomerase-II-Inhibitor 1 mM Muller, S. O., Eckert, I., Lutz, W. K., Stopper, H. 1996. Genotoxicity of the Laxative Drug Components Emodin, Aloe-emodin and Danthron in Mammalian Cells: Topoisomerase II Mediated? Mutat Res, 371: 165-173. Topoisomerase-II-Inhibitor IC50=741 uM/ml Mueller, S. O., Stopper, H. 1999. Characterization of the Genotoxicity of Anthraquinones in Mammalian Cells. Biochimica & Biophysica Acta, 1428: 406-414. Tuberculostatic Pakistan Encyclopedia Planta Medica. 1986.
24	ALOE-EMODIN	Bulb	--	--	--	*
Antibacterial MIC=2-64 ug/ml * Antiherpetic * Antileukemic * Antisalmonella Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antiseptic MIC=2-64 ug/ml * Antistaphylococcic MIC=2-64 ug/ml * Antitumor 1 ug/mL * Antiviral * Arylamine-N-Acetyltransferase-Inhibitor * Calcium-Antagonist (strong activity) * Candidicide MIC=25-250 ug/ml * Cathartic Merck 11th Edition Cytotoxic 20 ppm * Estrogenic * Fungicide MIC=25-250 ug/ml * Genotoxic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Laxative * Mutagenic * Pesticide * Purgative ED50=>59.6 mg/kg orl mus * Termitifuge Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Topoisomerase-II-Inhibitor 1 mM Muller, S. O., Eckert, I., Lutz, W. K., Stopper, H. 1996. Genotoxicity of the Laxative Drug Components Emodin, Aloe-emodin and Danthron in Mammalian Cells: Topoisomerase II Mediated? Mutat Res, 371: 165-173. Topoisomerase-II-Inhibitor IC50=741 uM/ml Mueller, S. O., Stopper, H. 1999. Characterization of the Genotoxicity of Anthraquinones in Mammalian Cells. Biochimica & Biophysica Acta, 1428: 406-414. Tuberculostatic Pakistan Encyclopedia Planta Medica. 1986.
24	ALOE-EMODIN	Root	--	--	--	*
Antibacterial MIC=2-64 ug/ml * Antiherpetic * Antileukemic * Antisalmonella Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antiseptic MIC=2-64 ug/ml * Antistaphylococcic MIC=2-64 ug/ml * Antitumor 1 ug/mL * Antiviral * Arylamine-N-Acetyltransferase-Inhibitor * Calcium-Antagonist (strong activity) * Candidicide MIC=25-250 ug/ml * Cathartic Merck 11th Edition Cytotoxic 20 ppm * Estrogenic * Fungicide MIC=25-250 ug/ml * Genotoxic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Laxative * Mutagenic * Pesticide * Purgative ED50=>59.6 mg/kg orl mus * Termitifuge Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Topoisomerase-II-Inhibitor 1 mM Muller, S. O., Eckert, I., Lutz, W. K., Stopper, H. 1996. Genotoxicity of the Laxative Drug Components Emodin, Aloe-emodin and Danthron in Mammalian Cells: Topoisomerase II Mediated? Mutat Res, 371: 165-173. Topoisomerase-II-Inhibitor IC50=741 uM/ml Mueller, S. O., Stopper, H. 1999. Characterization of the Genotoxicity of Anthraquinones in Mammalian Cells. Biochimica & Biophysica Acta, 1428: 406-414. Tuberculostatic Pakistan Encyclopedia Planta Medica. 1986.
0	ALOE-EMODIN-8-MONO-BETA-D-GLUCOSIDE	Root	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
0	ALOE-EMODIN-8-O-BETA-D-GLUCOPYRANOSIDE	Plant	--	--	--	*
0	ANTHRACENES	Root	30000.0	50000.0	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Rheum officinale (Polygonaceae)

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