Mitragyna speciosa | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Kratum

How used

Medicinal

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Activities: 79

Chemicals w/Activities: 10

All Chemicals: 25

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Exclude ubiquitous chemicals - View the list of ubiquitous chemicals

List of all chemical
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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
38	(-)-EPICATECHIN	Leaf	--	150.0	-0.73	*
5-Lipoxygenase-Inhibitor IC50=22-50 uM/l * ACE-Inhibitor IC50=0.216 mM/l * ACE-Inhibitor 0.5 mg/ml rbt (weak activity) * Allelochemic Hanke, F. J., Natural Products as a Resource for Biologically Active Compounds, Thesis, U. Cal (Santa Cruz), 1986, 252 pp Antiaggregant * Antianaphylactic * Antibacterial * Antidiabetic 30 mg/kg rat * AntiEBV Economic & Medicinal Plant Research, 6: 189. Antihepatitic Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. AntiHIV EC50=2 ug/ml * Antihyperglycemic * Antiinflammatory * Antileukemic Economic & Medicinal Plant Research, 6: 189. Antileukotriene * Antilipoperoxidant * Antimutagenic * Antioxidant IC50=6.3 ug/ml * Antiperoxidant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral EC50=2 ug/ml * Beta-Adrenergic Receptor Blocker 10 uM Zhu, M., Phillipson, J. D., Greengrass, P. M., Bowery, N. E., Cai, Y. 1997. Plant Polyphenols: Biologically Active Compounds or Non-Selective Binders to Protein? Phytochemistry, 44(3): 441-447. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardiotonic * Choline-Sparing * COMP-Inhibitor Dullo, A. G., et al. 1999. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am. J. Clinical Nutrition, 70: 1040-1045. Cytotoxic TC50=>100 ug/ml * Hypocholesterolemic * Hypoglycemic * Immunostimulant * Insulinogenic Economic & Medicinal Plant Research, 6: 170. Lipoxygenase-1-Inhibitor IC50=60 mM * Lipoxygenase-Inhibitor IC50=140 uM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Lipoxygenase-Inhibitor IC97=5 mM Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690. Pancreatogenic * Pesticide * Reverse-Transcriptase-Inhibitor 10 ng/ml McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Vasodilator uM McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Xanthine-Oxidase-Inhibitor IC50=>40 Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
0	3-DEHYDROMITRAGYNINE	Leaf	--	36.0	--	*
11	AJMALICINE	Leaf	--	--	--	*
Adrenolytic Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Antiadrenergic ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes. Antiaggregant * Antidiuretic Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Antihypertensive Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Cerebrocirculant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Circulotonic Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. CNS-Depressant * Hypotensive Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Sympatholytic Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Tranquilizer Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
0	CORYNANTHEIDALINE	Leaf	--	--	--	*
0	CORYNANTHEIDINE	Leaf	--	--	--	*
40	EPICATECHIN	Leaf	--	150.0	-1.00	*
Allelochemic IC100=1 mM Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Anabolic * Antiaggregant IC94=200 ug/ml * Antianaphylactic * Antibacterial MIC=>1,000 ug/ml * Anticomplementary 1/2 aspirin * Antidiabetic 30 mg/kg rat * AntiEBV Economic & Medicinal Plant Research, 6: 189. Antifeedant * Antihepatitic Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. AntiHIV EC50=2 ug/ml * Antihyperglycemic * Antiinflammatory * Antileukemic IC50=>10 ug/ml * Antilipoperoxidant * Antimutagenic * Antioxidant 2.5 x Vit. E * Antioxidant IC50=10.2 uM * Antioxidant 3/4 quercetin * Antioxidant IC50=6.3 ug/ml Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990. Antiperoxidant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardiotonic * Choline-Sparing Singleton, V.L. 1981. Naturally Occurring Food Toxicants: Phenolic Substances of Plant Origin Common in Foods. Advances in Food Research 27: 149-217. Hepatotropic * Hypocholesterolemic Singleton, V.L. 1981. Naturally Occurring Food Toxicants: Phenolic Substances of Plant Origin Common in Foods. Advances in Food Research 27: 149-217. Hypoglycemic * Insulinogenic Economic & Medicinal Plant Research, 6: 170. Interleukin-1-alpha-Inhibitor * Interleukin-6-mRNA-Inhibitor * Lipoxygenase-Inhibitor IC50=140 uM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Lipoxygenase-Inhibitor IC97=5 mM Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690. NO-Inhibitor * Pancreatogenic * Peroxynitrite-Scavenger IC50=0.181 ug/ml * Pesticide * Propecic * TNF-alpha-Inhibitor * Xanthine-Oxidase-Inhibitor IC50=>40 *
0	ISOMITRAFOLINE	Plant	--	--	--	*
3	ISOMITRAPHYLLINE	Leaf	--	--	--	*
Antileukemic IC50=45-60 uM/l * Immunostimulant * Phagocytotic *
0	ISOSPECIOFOLINE	Plant	--	--	--	*
0	MITRACILIATINE	Leaf	--	32.0	--	*
0	MITRAGYNALINE	Leaf	--	--	--	*
6	MITRAGYNINE	Leaf	--	86.0	--	*
Analgesic Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176) Anesthetic * CNS-Stimulant * Hypotensive * Myorelaxant * Vasodilator *
0	MITRAGYNOL	Plant	--	--	--	*
12	MITRAPHYLLINE	Leaf	--	--	--	*
Anesthetic Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Antihypertensive Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Antileukemic IC50=60-120 uM/l * Cardiodepressant Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. CNS-Depressant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Hypotensive Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Immunostimulant * Myocontractant Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Myorelaxant * Pesticide * Protisticide Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Vasodilator *
0	MITRASPECINE	Seed	--	--	--	*
0	MITRAVERSINE	Plant	--	--	--	*
0	PAYNANTHEINE	Leaf	--	50.0	--	*
23	RHYNCHOPHYLLINE	Leaf	--	--	--	*
Anesthetic Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Antiaggregant * Antidementia * Antiexcitotoxic * Antihypertensive * Antiischemic * Antioxidant * Antipyretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiradicular * Antithrombotic * Calcium-Antagonist 10.1 uM rat * Calcium-Blocker * Cardiodepressant Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Dopaminergic * Febrifuge * Hypotensive * Myocontractant Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Neuroparalytic * Protisticide Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp. Sedative * Serotonergic * Uterotonic * Vasodilator *
0	ROTUNDIFOLINE	Plant	--	--	--	*
2	SPECIOCILIATINE	Leaf	--	30.0	--	*
Analgesic * Antitussive *

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Mitragyna speciosa (Rubiaceae)

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