Mentha x rotundifolia | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Applemint

How used

GRAS

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Activities: 396

Chemicals w/Activities: 40

All Chemicals: 60

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List of all chemical
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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
1	(+)-PIPERITENONE-OXIDE	Leaf	8.0	8510.0	0.22	*
Antiacetylcholinesterase IC50=64 ug/ml *
4	(+)-PULEGONE	Leaf	--	170.0	-1.09	*
Antiacetylcholinesterase IC50=136 ug/ml * Antiacetylcholinesterase IC50=0.9 mM * Irritant ZEB * Perfumery ZEB *
0	(-)-CARVONE	Leaf	240.0	4000.0	-1.41	*
0	(-)-LIMONENE	Leaf	--	--	--	Jim Duke's personal files.
0	1,2-EPOXY-(1S,2S,3R,4S)-MENTHOL-ACETATE	Shoot	--	--	--	Jim Duke's personal files.
0	1,2-EPOXY-NEOMENTHOL-ACETATE	Leaf	6.0	7390.0	--	Jim Duke's personal files.
2	ALLO-CYMENE	Shoot	6.0	100.0	--	*
ACE-Inhibitor 100 ug/ml (weak activity) * Aldose-Reductase-Inhibitor 100 ug/ml (weak activity) Okamura, K., Iwakami, S., Matsunaga, T. 1992. Biological Activity of Monoterpenes from Trees. Toyama-Ken Yakuji Kenkyusho Nenpo, (20): 95-101.
11	ALPHA-PHELLANDRENE	Leaf	16.0	280.0	-0.12	*
Antibacterial Wright,C.W.(Ed)2002.Medicinal&Aromatic Plants-Industrial Profiles.Artemisia.344pp.Maffei,M.(Ed)2002.Vetiveria.The Genus Vetiveria.Taylor&Francis.NY,NY.191pp.Southwell,I.,Lowe,R.(Eds)1999.Tea Tree.The Genus Melaleuca.Harwood Acad.Pub.Amsterdam,Netherlands. Antistaphylococcic Wright,C.W.(Ed)2002.Medicinal&Aromatic Plants-Industrial Profiles.Artemisia.344pp.Maffei,M.(Ed)2002.Vetiveria.The Genus Vetiveria.Taylor&Francis.NY,NY.191pp.Southwell,I.,Lowe,R.(Eds)1999.Tea Tree.The Genus Melaleuca.Harwood Acad.Pub.Amsterdam,Netherlands. Dermal Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Emetic * FLavor FEMA 10-130 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Fungicide Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Insectiphile Pakistan Encyclopedia Planta Medica. 1986. Irritant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Laxative * Perfumery Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide *
28	ALPHA-PINENE	Leaf	4.0	430.0	-0.20	*
Allelochemic * Allergenic * Antiacne * Antibacterial * Antifeedant * Antiflu Economic & Medicinal Plant Research, 5: 195. Antiinflammatory 500 mg/kg * Antipneumonic * Antiseptic * Antispasmodic * Antistaphylococcic * Antiviral Economic & Medicinal Plant Research, 5: 195. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Coleoptophile * Expectorant Michael Castleman 1991. The Healing Herbs. Rodale Press, Emmaus, PA 436 pp. FLavor FEMA 15-150 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Herbicide IC50=30 uM Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Insecticide 0.82 uM/fly * Insectifuge 50 ppm * Insectiphile J. Stored. Prod. Res., 22:141, 1986. Irritant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. P450-2B1-Inhibitor IC50=0.087 uM * Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Pesticide * Sedative Lawrence Review of Natural Products, Jun-90. Spasmogenic * Tranquilizer Lawrence Review of Natural Products, Jun-90. Transdermal *
101	APIGENIN	Shoot	--	--	--	Jim Duke's personal files.
11B-HSD-Inhibitor * AntiADD * Antiaflatoxin IC50=9.52 uM * Antiaflatoxin IC50=2.57 ppm * Antiaggregant * Antiaging * Antiallergic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiangiogenic 4 uM * Antiarrhythmic * Antibacterial Recio, M. C., Rios, J. L., and Villar, A., A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978-1988, Phytotherapy Research, 3(4), 1989, 117-125. Anticancer (Lung) * Anticomplementary * Antidermatitic Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp. Antiestrogenic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antiherpetic 20-54 ug/ml * Antihistaminic IC50=10-35 uM * AntiHIV IC50=143 ug/ml * AntiHIV IC72=200 ug/ml * Antiinflammatory IC~65=1,000 uM * Antiinflammatory #NAME? * Antileukemic 20-50 uM * Antimelanomic 1-50 uM * Antimetastatic 1-50 uM * Antimutagenic ID50=0.55 ug/ml * Antimutagenic ID50=10-40 nM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antioxidant 1.5 x Vit. E * Antioxidant IC28.5=62.5 ug/ml * Antiperistaltic * Antiproliferant IC50=155 uM * Antiproliferant 1-50 uM * Antispasmodic EC50=1-5 uM * Antistress 10 mg/kg * Antithyroid Jim Duke's personal files. Antitumor 1-50 uM * Antitumor (Breast) 1-50 uM * Antitumor (Lung) * Antitumor (Skin) * Antiviral 20-54 ug/ml * Anxiolytic 10 mg/kg * Apoptotic 12-60 uM * Aromatase-Inhibitor IC65=1 uM/l Journal of Medicinal Food 2: 235.1999. Beta-Glucuronidase-Inhibitor IC50=~40 uM * Calcium-Antagonist? Biochimica & Biophysica Acta, 1115: 69, 1991. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Choleretic * CNS-Depressant * COX-1-Inhibitor IC65=1,000 uM * COX-2-Inhibitor <40 uM * COX-2-Inhibitor IC50=<15 uM * COX-2-Inhibitor IC>65=1,000 uM * Cyclooxygenase-Inhibitor * Cytochrome-P450-1A1-Inhibitor * Cytotoxic 1-50 uM * Cytotoxic IC50=9.5 uM * Cytotoxic IC88=10 ug/ml Planta Medica, 57: A113, 1991. Deiodinase-Inhibitor Jim Duke's personal files. Differentiator MIC=30 uM * Differentiator IC40=40 uM * Diuretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. DNA-Protective * Estrogenic 16% genistein * Estrogenic EC50=1 uM * Estrogenic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. HIF-1alpha-Inhibitor * Hyaluronidase-Inhibitor IC50+=50-250 uM * Hypotensive Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. ICAM-1-Inhibitor * IKK-Inhibitor * iNOS-Inhibitor IC50=<15 uM * Inotropic * Interleukin-6-Inhibitor * MAO-Inhibitor * MAPK-Inhibitor * Musculotropic Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Mutagenic * Myorelaxant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. NADH-Oxidase-Inhibitor * NF-kB-Inhibitor * NO-Synthase-Inhibitor 5-50 uM * Nodulation-Signal Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Ornithine-Decarboxylase-Inhibitor * P21-Inducer 10-70 uM * Pesticide * PKC-Inhibitor IC50=10 uM * Polyamine-Synthesis-Inhibitor * Progestational * Protein-Kinase-C-Inhibitor IC50=10-40 uM * PTK-Inhibitor 10-100 uM * Quinone-Reductase-Inducer 20 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216. Radioprotective * Sedative 30-100 mg/kg * Sunscreen * TNF-alpha-Inhibitor IC50=3.27 uM * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237. Topoisomerase-II-Inhibitor IC28=18 uM * Topoisomerase-II-Inhibitor 50 ug/ml Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318. Topoisomerase-II-Inhibitor IC45=180 uM * Uterotrophic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Vasodilator * VEGF-Inhibitor IC50=2-7 uM * Xanthine-Oxidase-Inhibitor 0.36 uM *
13	BETA-PINENE	Leaf	9.0	330.0	0.06	*
Allergenic * Antiinflammatory * Antiseptic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Antispasmodic * Candidicide * FLavor FEMA 15-600 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Herbicide Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Irritant Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253. Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Pesticide * Spasmogenic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Transdermal *
0	BORNEOL-ACETATE	Leaf	25.0	420.0	--	*
102	CAFFEIC-ACID	Shoot	--	--	--	Jim Duke's personal files.
Aldose-Reductase-Inhibitor 4 ug/ml (weak activity) Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110. Allergenic * Analgesic * Antiadenoviral Economic & Medicinal Plant Research, 5: 207. Antiaggregant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiaging * Antiatherogenic * Antibacterial * Anticancer * Anticarcinogenic Economic & Medicinal Plant Research, 6: 189. Antidepressant * Antiedemic Economic & Medicinal Plant Research, 6: 189. Antielastase IC50=86 ug/ml (475 uM) * Antielastase IC50=93 um/l * Antiescherichic * Antiflu Economic & Medicinal Plant Research, 5: 207. Antigonadotropic Jim Duke's personal files. Antihemolytic 25 uM Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., and Kido, R. 1993. Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. Phytochemistry. 36(3): 579-583. 1994. Antihepatoadenomic 200 ppm diet orl mus * Antihepatotoxic * Antiherpetic EC50=>50 ug/ml * Antiherpetic 50 ug/ml * Antihistaminic * AntiHIV EC50=200 ug/ml * Antihypercholesterolemic Economic & Medicinal Plant Research, 6: 189. Antihyperthyroid * Antiinflammatory * AntiLegionella * Antileukemic Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antileukotriene * Antimelanogenic * Antimutagenic Ki Soon Rhee. Oilseed Food Ingredients Used To Minimize Oxidative Flavor Deterioration in Meat Products. Phenolic Compounds in Food and Their Effects on Health, Ch.18. Antinitrosaminic Ki Soon Rhee. Oilseed Food Ingredients Used To Minimize Oxidative Flavor Deterioration in Meat Products. Phenolic Compounds in Food and Their Effects on Health, Ch.18. Antiophidic * Antioxidant 1/3 quercetin * Antioxidant 50 uM * Antioxidant 1/2 BHA * Antioxidant IC57=30 ppm * Antioxidant 30 mM * Antioxidant 1.3 x Vit. E * Antiperoxidant IC85=100 ug/ml * Antiperoxidant IC35=200 ug/ml * Antiperoxidant IC50=44 uM Planta Medica, 57: A54, 1991. Antiproliferant Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antiprostaglandin * Antiradicular 1/3 quercetin * Antiradicular 30 mM * Antiradicular 10 uM Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., and Kido, R. 1993. Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. Phytochemistry. 36(3): 579-583. 1994. Antiradicular IC50=32-35 uM * Antiseptic * Antispasmodic EC50=3.4-15 uM Phytotherapy Research, 4: 73. Antistaphylococcic * Antistomatitic Economic & Medicinal Plant Research, 5: 207. Antisunburn * Antithiamin Phenolic Compounds in Food and Their Effects on Health, 69. Antithyroid Jim Duke's personal files. Antitumor 200 ppm diet orl mus * Antitumor (Skin) * Antitumor-Promoter IC42=10 uM Cancer Research, 48: 5941. Antiulcerogenic * Antivaccinia Economic & Medicinal Plant Research, 5: 207. Antiviral IC50=62.5 ug/ml * Anxiolytic * Calcium-Antagonist IC50=1.2 uM rbt * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Carcinogenic 2% (diet) * Chemopreventive * Cholagogue Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Choleretic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Clastogenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. CNS-Active Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. Co-carcinogenic * Collagen-Sparing * COX-2-Inhibitor IC32=100 uM * Cytoprotective Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Cytotoxic TC50=200 ug/ml * Diuretic Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp. DNA-Active Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. DNA-Protective * Fungicide MIC=0.4 mg/ml * Hepatocarcinogenic 400 ppm diet orl mus (in the absence of alcohol) * Hepatoprotective Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 210. Hepatotropic * Histamine-Inhibitor * Immunostimulant * Insectifuge Tunon, H., Thorsell, W., and Bohlin, L. 1993. Mosquito Repelling Activity of Compounds Occurring in Achillea millefolium L. (Asteraceae). Economic Botany 48(2): 111-120, 1994. Leukotriene-Inhibitor * Lipoxygenase-Inhibitor IC27=5 mM Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690. Lipoxygenase-Inhibitor IC50=62-148 uM * Lyase-Inhibitor IC50=94-164 uM * Metal-Chelator McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25. Ornithine-Decarboxylase-Inhibitor Hagerman, A.E. Tannin-Protein Interactions. Phenolic Compounds in Food and Their Effects on Health, Ch.19. Pesticide * Prooxidant * Prostaglandigenic * Sedative 500 mg * Sunscreen IC50=2.5 mg/l Lazarova, G., Kostova, I., Neychev, H. 1992. Photodynamic damage prevention by some hydroxycoumarins. Fitoterapia 64(2): 134-136, 1993. Sunscreen IC91=5 mg/l Lazarova, G., Kostova, I., Neychev, H. 1992. Photodynamic damage prevention by some hydroxycoumarins. Fitoterapia 64(2): 134-136, 1993. Sunscreen IC98=25 mg/l Lazarova, G., Kostova, I., Neychev, H. 1992. Photodynamic damage prevention by some hydroxycoumarins. Fitoterapia 64(2): 134-136, 1993. Tumorigenic Jim Duke's personal files. Vulnerary Xanthine-Oxidase-Inhibitor IC50=39.21 uM Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh.
28	CALCIUM	Leaf	--	16300.0	-0.15	CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses
Antiallergic 500 mg/day * Antianxiety Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antiarrhythmic 500-1,500 mg * Antiarthritic 1,000 mg/day * Antiatherosclerotic 500 mg/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Anticlimacteric 1,000-1,500 mg/day * Antidepressant Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antidote (Aluminum) Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antidote (Lead) Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antihyperkinetic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antihypertensive * Antiinsomniac Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Antimenopausal 1,000-1,500 mg/day * Antiobesity * Antiosteoporotic 500-2,000 mg/day * Antiperiodontitic 750 mg/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. AntiPMS 1 g/day * Antirheumatic 1,000 mg/day * Antistress 500-1,500 mg/day * Antitic Davies, S., and Stewart, A. 1990. Nutritional Medicine. Avon Books, New York. 509pp. Anxiolytic 500-1,500 mg/day * Calcium-Channel-Blocker * Diuretic * Hypocholesterolemic 500 mg/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Hypotensive 1 g/day Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp. Laxative 1,000-1,200 mg * Tranquilizer 500-1,500 mg/day * Vasodilator *
9	CAMPHENE	Leaf	0.0	20.0	-0.19	*
Allelopathic Wright,C.W.(Ed)2002.Medicinal&Aromatic Plants-Industrial Profiles.Artemisia.344pp.Maffei,M.(Ed)2002.Vetiveria.The Genus Vetiveria.Taylor&Francis.NY,NY.191pp.Southwell,I.,Lowe,R.(Eds)1999.Tea Tree.The Genus Melaleuca.Harwood Acad.Pub.Amsterdam,Netherlands. Antilithic? Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antioxidant Jim Duke's personal files. Expectorant Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. FLavor FEMA 15-175 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Hypocholesterolemic? Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Pesticide * Spasmogenic Fitoterapia No.59-1984.
19	CARVONE	Leaf	260.0	5000.0	0.74	*
Allergenic * Antiacetylcholinesterase IC50=1.4-1.8 mM * Antiproliferative * Antiseptic 1.5 x phenol Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176) Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidistat * Carminative Yamamoto, A., Umemori, S., and Muranishi, S. 1993. Absorption Enhancement of Intrapulmonary Administered Insulin by Various Absorption Enhancers and Protease Inhibitors in Rats. J. Pharm. Pharmacol. 46: 14-18, 1994. CNS-Stimulant * FLavor FEMA 80-3,000 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Fungistat * Insecticide Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Motor-Depressant Buchbauer et al, e.g.Buchbauer et al,1993.Therapeutic properties of essential oils and fragrances. Chap.12 in Teranishi,R, Buttery,R.G and Sugisawa,H. Eds. Bioactive Volatile Compounds from Plants. ACS Symposium Series 525. Amer. Chem. Soc., Washington DC Nematicide MLC=1 mg/ml Shoyakugaku Zasshi, 44: 183. Perfumery Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Pesticide * Sedative Buchbauer et al, e.g.Buchbauer et al,1993.Therapeutic properties of essential oils and fragrances. Chap.12 in Teranishi,R, Buttery,R.G and Sugisawa,H. Eds. Bioactive Volatile Compounds from Plants. ACS Symposium Series 525. Amer. Chem. Soc., Washington DC Trichomonicide LD100=300 ug/ml * Vermicide *
0	CINEOLE	Leaf	4.0	120.0	-0.93	*
53	CITRAL	Shoot	9.0	150.0	1.00	*
Allergenic * Antiallergenic * Antiallergic Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Antianaphylactic * Antibacterial * Anticancer * Antihelicobacter * Antiherpetic * Antihistaminic Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Antiinflammatory * Antileishmanic * Antioxidant * Antiseptic 5.2 x phenol * Antishock Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Antispasmodic * Antitumor * Antitumor (Colon) * Antitumor (Liver) * Antitumor (Skin) * Antiulcer * Antiviral * Apoptotic * Barbituate-Synergist * Bronchorelaxant Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. Calcium-Antagonist * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Carcinogenic * Caspase-3-Inducer * Chemopreventive * Cytotoxic * Estrogenic * Expectorant Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp. FLavor FEMA 4-170 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Fungicide MIC 625 ug/ml * Glaucomagenic * Glutathionigenic * Herbicide IC50=115 uM Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Myorelaxant 200 mg/kg * Nematicide IC52=100 ug/ml Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. Nematicide MLC=100-260 ug/ml Shoyakugaku Zasshi, 44: 183. NF-kB-Inhibitor * NO-Inhibitor * P450-2B1-Inhibitor IC50=1.19 uM * Perfumery Merck 11th Edition Pesticide * Prostatitigenic 185 mg/kg/day/3 ms * Sedative ED 1-32 mg/kg Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176) Sedative 1 mg/kg * Teratogenic * Trichomonicide LD100=150 ug/ml * Trypanocide * Tyrosinase-Inhibitor ID50=1.5 mM * Tyrosinase-Inhibitor ID50=1,500 uM *
7	CYANIDIN	Shoot	--	--	--	Jim Duke's personal files.
Allelochemic IC90=1 mM Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Antioxidant 4.4 x Vit. E * Antioxidant ID50=3.5-22 uM * Metal-Chelator (Copper) * Pesticide * Pigment Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Prooxidant *
9	DELPHINIDIN	Shoot	--	--	--	Jim Duke's personal files.
Allelochemic IC81=1 mM Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Allergenic * Antioxidant ID50=0.7-2.4 uM * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Metal-Chelator (Copper) * NO-Inhibitor IC78=250 uM * Pesticide * Pigment Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Prooxidant *

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Mentha x rotundifolia (Lamiaceae)

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