Collinsonia canadensis | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Stone Root

How used

Medicinal

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Activities: 159

Chemicals w/Activities: 15

All Chemicals: 21

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
0	16-ALPHA-HYDROXYHEDERAGENIN	Root	--	--	--	*
0	6	Plant	--	--	--	*
2	AKEBOSIDE	Root	--	--	--	*
Fungicide * Pesticide *
0	ALPHA-NAGITANINE	Plant	--	8.0	--	Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980.
28	ALPHA-PINENE	Plant	--	--	--	*
Allelochemic * Allergenic * Antiacne * Antibacterial * Antifeedant * Antiflu Economic & Medicinal Plant Research, 5: 195. Antiinflammatory 500 mg/kg * Antipneumonic * Antiseptic * Antispasmodic * Antistaphylococcic * Antiviral Economic & Medicinal Plant Research, 5: 195. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Coleoptophile * Expectorant Michael Castleman 1991. The Healing Herbs. Rodale Press, Emmaus, PA 436 pp. FLavor FEMA 15-150 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Herbicide IC50=30 uM Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Insecticide 0.82 uM/fly * Insectifuge 50 ppm * Insectiphile J. Stored. Prod. Res., 22:141, 1986. Irritant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. P450-2B1-Inhibitor IC50=0.087 uM * Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Pesticide * Sedative Lawrence Review of Natural Products, Jun-90. Spasmogenic * Tranquilizer Lawrence Review of Natural Products, Jun-90. Transdermal *
5	BETA-ELEMENE	Plant	--	16.0	-0.42	Lawrence, B.M., Essential Oils 1976-1977, Essential Oils 1978, Essential Oils 1979-1980.
Anticancer (Cervix) Medicinal and Poisonous Plants of the Tropics. Leeuwenberg, A.J.M., ed. Pudoc, Wageningen. 1987. Antigliomic * Antiproliferant * Antitumor (Cervix) Medicinal and Poisonous Plants of the Tropics. Leeuwenberg, A.J.M., ed. Pudoc, Wageningen. 1987. Apoptotic *
13	BETA-PINENE	Plant	--	--	--	*
Allergenic * Antiinflammatory * Antiseptic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Antispasmodic * Candidicide * FLavor FEMA 15-600 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Herbicide Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Irritant Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253. Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Pesticide * Spasmogenic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Transdermal *
31	CARYOPHYLLENE	Tuber	--	--	--	*
Aldose-Reductase-Inhibitor * Allergenic * Analgesic Taylor, Leslie. 2005. The Healing Power of Rainforest Herbs. SquareOne Publisher, Garden City Park, NY. 519 pp. Antiacne * Antiasthmatic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Antibacterial * Anticariogenic MIC=>1,600 ug/ml Muroi, H. and Kubo, I. 1993. Combination Effects of Antibacterial Compounds in Green Tea Flavor against Streptococcus mutans. J. Agric. Food Chem. 41: 1102-1105. Antidermatitic * Antiedemic Shimizu,M., et al. 1990. Anti-inflammatory Constituents of Topically Applied Crude Drugs. IV.1) Constituents and Anti-inflammatory Effect of Paraguayan Crude Drug 'Alhucema' (Lavandula latifolia Vill.)2). Chem. Pharm. Bull. 38(8): 2283-2284, 1990. Antifeedant 500 ppm Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Antiinflammatory IC50=100 uM Shimizu,M., et al. 1990. Anti-inflammatory Constituents of Topically Applied Crude Drugs. IV.1) Constituents and Anti-inflammatory Effect of Paraguayan Crude Drug 'Alhucema' (Lavandula latifolia Vill.)2). Chem. Pharm. Bull. 38(8): 2283-2284, 1990. Antileishmanic * Antionychyotic Taylor, Leslie. 2005. The Healing Power of Rainforest Herbs. SquareOne Publisher, Garden City Park, NY. 519 pp. Antiproliferant * Antispasmodic * Antistaphylococcic * Antistreptococcic * Antitumor Zheng, G-Q., Kenney, P.M., and Lam, L.K.T. Sesquiterpenes From Clove (Eugenia caryophyllata) As Potential Anticarcinogenic Agents. Journal of Natural Products 55(7): 999-1003, 1992. Antiulcer Taylor, Leslie. 2005. The Healing Power of Rainforest Herbs. SquareOne Publisher, Garden City Park, NY. 519 pp. Candidicide * FLavor FEMA 20-200 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Fungicide * Gastroprotective Taylor, Leslie. 2005. The Healing Power of Rainforest Herbs. SquareOne Publisher, Garden City Park, NY. 519 pp. Insectifuge * Irritant Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253. Larvicide * Mosquitocide * Perfumery Merck 11th Edition Pesticide * Sedative * Termitifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.
31	CARYOPHYLLENE	Plant	2.0	6.0	-0.57	*
Aldose-Reductase-Inhibitor * Allergenic * Analgesic Taylor, Leslie. 2005. The Healing Power of Rainforest Herbs. SquareOne Publisher, Garden City Park, NY. 519 pp. Antiacne * Antiasthmatic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Antibacterial * Anticariogenic MIC=>1,600 ug/ml Muroi, H. and Kubo, I. 1993. Combination Effects of Antibacterial Compounds in Green Tea Flavor against Streptococcus mutans. J. Agric. Food Chem. 41: 1102-1105. Antidermatitic * Antiedemic Shimizu,M., et al. 1990. Anti-inflammatory Constituents of Topically Applied Crude Drugs. IV.1) Constituents and Anti-inflammatory Effect of Paraguayan Crude Drug 'Alhucema' (Lavandula latifolia Vill.)2). Chem. Pharm. Bull. 38(8): 2283-2284, 1990. Antifeedant 500 ppm Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Antiinflammatory IC50=100 uM Shimizu,M., et al. 1990. Anti-inflammatory Constituents of Topically Applied Crude Drugs. IV.1) Constituents and Anti-inflammatory Effect of Paraguayan Crude Drug 'Alhucema' (Lavandula latifolia Vill.)2). Chem. Pharm. Bull. 38(8): 2283-2284, 1990. Antileishmanic * Antionychyotic Taylor, Leslie. 2005. The Healing Power of Rainforest Herbs. SquareOne Publisher, Garden City Park, NY. 519 pp. Antiproliferant * Antispasmodic * Antistaphylococcic * Antistreptococcic * Antitumor Zheng, G-Q., Kenney, P.M., and Lam, L.K.T. Sesquiterpenes From Clove (Eugenia caryophyllata) As Potential Anticarcinogenic Agents. Journal of Natural Products 55(7): 999-1003, 1992. Antiulcer Taylor, Leslie. 2005. The Healing Power of Rainforest Herbs. SquareOne Publisher, Garden City Park, NY. 519 pp. Candidicide * FLavor FEMA 20-200 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Fungicide * Gastroprotective Taylor, Leslie. 2005. The Healing Power of Rainforest Herbs. SquareOne Publisher, Garden City Park, NY. 519 pp. Insectifuge * Irritant Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253. Larvicide * Mosquitocide * Perfumery Merck 11th Edition Pesticide * Sedative * Termitifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.
0	COLLINSOGENIN	Root	--	--	--	*
2	COLLINSONIDIN	Root	--	--	--	*
Fungicide * Pesticide *
2	COLLINSONIN	Root	--	--	--	*
Fungicide * Pesticide *
9	DELTA-CADINENE	Plant	--	13.0	-0.47	*
Aldose-Reductase-Inhibitor * Antiacne * Antibacterial MIC800 ug/ml Muroi, H. and Kubo, I. 1993. Combination Effects of Antibacterial Compounds in Green Tea Flavor against Streptococcus mutans. J. Agric. Food Chem. 41: 1102-1105. Anticariogenic MIC800 ug/ml Muroi, H. and Kubo, I. 1993. Combination Effects of Antibacterial Compounds in Green Tea Flavor against Streptococcus mutans. J. Agric. Food Chem. 41: 1102-1105. Antistreptococcic * Cytochrome-P450-Inducer * P450-Inducer * Pesticide * Testosterone-Inducer *
16	ELEMICIN	Plant	--	18.0	--	*
Antiaggregant IC50=360 uM Janssens, J., Laekeman, G.M., Pieters, L.A.C., Totte, J., Herman, A.G., and Vlietinck, A.J. 1990. Nutmeg Oil: Identification and Quantitation of its Most Active Constituents as Inhibitors of Platelet Aggregation. J.of Ethnopharmacology, 29: 179-188, 1990. Antidepressant ihl Jim Duke's personal files. Antifeedant Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Antihistaminic * Antiserotonic Internat. J. Oriental Med. 15(4): 199, 1990+ Antistress ihl Jim Duke's personal files. DNA-Binder Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Fungicide MIC=8 ug * Hallucinogenic R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R. Hypotensive ihl Jim Duke's personal files. Insecticide 100 ppm * Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Larvicide 100 ppm * Neurotoxic R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R. Pesticide * Schistosomicide Grenand, P., Moretti, C., and Jacquemin, H. 1987. Pharmacopees Traditionnelles en Guyane. l'ORSTROM, Paris. 569 pp.
0	EO	Plant	--	500.0	-0.70	*
2	GERMACRENE-D	Plant	--	230.0	-0.23	*
Pesticide * Pheromone *
0	HEDERAGENIN-3-O-ALPHA-ARABINOPYRANOSIDE	Root	--	--	--	*
60	LIMONENE	Plant	--	--	--	*
Acaricide LC100=8 uM * AChE-Inhibitor Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8. Allelochemic * Allergenic 1/20th carene * Antiacetylcholinesterase IC22-26=1.2 mM * Antiadenomic * Antialzheimeran? Grundy, D. L. and Still, C. C., Inhibition of acetylcholinesterases by pulegone-1,2-epoxide, Oest. Biochem. & Physiol., 23, 1985, 383-8. Antiasthmatic * Antibacterial Revista Itiliana Eppos, 12: 5, 1994. Anticancer * Antiesophagitic * Antifeedant * Antiflu Economic & Medicinal Plant Research, 5: 195. Antiinflammatory * Antilithic * Antilymphomic * Antimetastatic (Stomach) * Antimutagenic Economic & Medicinal Plant Research, 6: 235. Antiobesity * Antiseptic * Antispasmodic ED50=0.197 mg/ml Fitoterapia No.59-1984. Antitumor * Antitumor (Breast) * Antitumor (Colon) * Antitumor (Pancreas) * Antitumor (Prostate) * Antitumor (Stomach) * Antiviral * Apoptotic * Bronchoprotectant * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidistat * Chemopreventive * Cholesterolytic * Detoxicant * Enterocontractant J. Aromatherapy 4: 22. Expectorant * FLavor * Fungiphilic J. Agric. Food Chem. 43: 2283. Fungistat * GST-Inducer * Herbicide IC50=45 uM Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Histaminic * Immunomodulator * Insecticide 0.37 uM/fly * Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Interleukin-6-Inhibitor * Irritant * Lipolytic * Myorelaxant 50 mg/kg * Nematicide IC=100 ug/ml Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp. NO-Genic * Ornithine-Decarboxylase-Inhibitor ~750 mg/kg (diet) * Ozone-Scavenger * P450-Inducer * Peristaltic * Pesticide * Photosensitizer Rinzler, C. A. 1990. The Complete Book of Herbs, Spices and Condiments. Facts on File, New York. 199 pp. Sedative ED=1-32 mg/kg Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176) Transdermal *
3	MUCILAGE	Plant	--	--	--	Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Demulcent * Hypocholesterolemic *
57	ROSMARINIC-ACID	Plant	--	--	--	*
ABeta-Inhibitor * Adenylate-Cyclase-Inhibitor * Aldose-Reductase-Inhibitor * Antiaggregant Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Antiallergic * Antialzheimeran * Antianaphylactic ID50=1 mg/kg ivn rat * Antianaphylactic ID50=10 mg/kg ims rat * Antianaphylactic 1-100 mg/kg orl Int. J. Immunopharmacology. Vol 10: 729, 1988. Antiatherosclerotic IC50=0.74 uM * Antibacterial Planta Medica, 55: 663. Anticoagulant Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Anticomplementary 20 mg/kg ivn Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Anticomplementary 1/2 aspirin * Antidepressant * Antiedemic 0.316-3.16 mg/kg ims Int. J. Immunopharmacology. Vol 10: 729, 1988. Antigonadotropic * Antihemolytic IC70=5-10 um/l Int. J. Immunopharmacology. Vol 10: 729, 1988. Antihepatotoxic * Antiherpetic 50 ug/ml Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart. Antiherpetic EC50=20 ug/ml * AntiHIV EC50=40 ug/ml * Antihyperthyroid * Antiinflammatory IC~58=1,000 uM * Antiintegrase 10 ug/ml * Antileukotriene * Antilipoperoxidant * Antimutagenic * Antinephritic * Antioxidant 10 uM * Antioxidant EC50=2.7 ug/ml Parveen, N. 1991. Antifilarial Activity of Vitex negundo Against Setaria cervi. Fitoterapia, 62(2): 163, 1991. Antioxidant (LDL) IC50=0.74 uM * Antiplaque * Antiproliferant * Antiprostaglandin 20 mg/kg ivn Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antiproteolytic IC50=0.9 mol l Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Antipulmonotic Tyler, V.E.. 1994. Antiradicular * Antishock Int. J. Immunopharmacology. Vol 10: 735, 1988. Antithyreotropic * Antithyroid Jim Duke's personal files. Antiuremic * Antiviral EC50=40 ug/ml * Anxiolytic * Apoptotic * Calcium-Antagonist IC50=1.2 uM rbt * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. COX-1-Inhibitor IC58=1,000 uM * COX-2-Inhibitor IC>58=1,000 uM * Cytotoxic TC50=100-150 ug/ml * Deiodinase-Inhibitor Jim Duke's personal files. Immunomodulator * Immunostimulant * Lipoxygenase-Inhibitor * Neuroprotective * Pesticide * Radioprotective *

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Collinsonia canadensis (Lamiaceae)

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