Chimaphila umbellata | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

King's Cure, Pipsissewa

How used

Medicinal

Data Views

Activities: 221

Chemicals w/Activities: 20

All Chemicals: 30

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
2	(-)-EPICATECHIN-GALLATE	Shoot	--	--	--	*
Acetyl-CoA-Carboxylase-Inhibitor IC50=~300-325 uM McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Antimutagenic Economic & Medicinal Plant Research, 6: 235.
0	2,7-DIMETHYL-1,4-NAPTHOQUINONE	Plant	--	2000.0	--	Leung, A.Y., Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, John Wiley & Sons, New York, 1980.
15	ARBUTIN	Plant	--	75000.0	0.24	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Allelochemic IC51=1.1 mM Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Antibacterial MIC=4,000-8,000 ppm * Antiedemic 50 mg/kg * Antimelanogenic IC50=40 uM * Antiseptic 60-200 mg/man * Antistreptococcic MIC=4,000-8,000 ppm Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antitussive Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Artemicide Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Candidicide Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Diuretic 60-200 mg/man Merck 11th Edition Insulin-Sparing Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Mycoplasmistat Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Pesticide * Tyrosinase-Inhibitor IC50=40 uM * Urinary-Antiseptic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
15	ARBUTIN	Shoot	73000.0	76000.0	--	*
Allelochemic IC51=1.1 mM Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Antibacterial MIC=4,000-8,000 ppm * Antiedemic 50 mg/kg * Antimelanogenic IC50=40 uM * Antiseptic 60-200 mg/man * Antistreptococcic MIC=4,000-8,000 ppm Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antitussive Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Artemicide Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Candidicide Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Diuretic 60-200 mg/man Merck 11th Edition Insulin-Sparing Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Mycoplasmistat Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Pesticide * Tyrosinase-Inhibitor IC50=40 uM * Urinary-Antiseptic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
15	ARBUTIN	Leaf	--	--	--	*
Allelochemic IC51=1.1 mM Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Antibacterial MIC=4,000-8,000 ppm * Antiedemic 50 mg/kg * Antimelanogenic IC50=40 uM * Antiseptic 60-200 mg/man * Antistreptococcic MIC=4,000-8,000 ppm Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Antitussive Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Artemicide Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Candidicide Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Diuretic 60-200 mg/man Merck 11th Edition Insulin-Sparing Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Mycoplasmistat Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. Pesticide * Tyrosinase-Inhibitor IC50=40 uM * Urinary-Antiseptic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
7	AVICULARIN	Plant	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Aldose-Reductase-Inhibitor IC32=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888. Aldose-Reductase-Inhibitor IC84=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888. Antibiotic CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses Cyclooxygenase-Activator 100 uM Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Diuretic CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses Pesticide * Tissue-Thromboplastin-Inhibitor IC50=54.8 uM *
9	BETA-AMYRIN	Plant	2100.0	2125.0	1.00	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Analgesic * Antiedemic IC27=40 mg/kg ipr rat * Antiinflammatory * Antinociceptive * Antiulcer * Gastroprotective * Hepatoprotective * Larvicide * Mosquitocide *
47	BETA-SITOSTEROL	Plant	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Androgenic * Angiogenic * Anorexic Martindale's 28th Antiadenomic Merck 11th Edition Antiandrogenic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antibacterial Recently became Internat. J. Crude Drug Res. 28(1,2,3,4):1990, page 155. Anticancer (Breast) Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103. Anticancer (Cervix) * Anticancer (Lung) * Antiedemic IC54=320 mg/kg orl * Antiestrogenic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antifeedant Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Antifertility Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antigonadotrophic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antihyperlipoproteinaemic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiinflammatory * Antileukemic * Antilymphomic * Antimutagenic 250 ug/ml * Antiophidic 2.3 mg mus Economic & Medicinal Plant Research, 5: 363. Antioxidant IC44=10 uM * Antiprogestational Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Antiprostaglandin 30 mg/day/12 wks * Antiprostatadenomic Merck 11th Edition Antiprostatitic 10-20 mg 3 x/day/orl man * Antipyretic Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Antitumor (Breast) Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103. Antitumor (Cervix) * Antitumor (Lung) * Antiviral Abid Ali Khan, M.M., Jain, D.C., Bhakuni, R.S., Zaim, M., and Thakur, R.S. 1991. Occurrence of some antiviral sterols in Artemisia annua. Plant Science, 75: 161-165, 1991. Apoptotic * Artemicide LC50=110 ppm Jung, J.H., Pummangura, S., Chaichantipyuth, c., Patarapanich, C., and McLaughlin, J.L. 1989. Bioactive Constituents of Melodorum fruticosum. Phytochemistry. 29(5): 1667-1670. 1990. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Candidicide Recently became Internat. J. Crude Drug Res. 28(1,2,3,4):1990, page 155. Caspase-8-Inducer * Estrogenic * Febrifuge Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp. Gonadotrophic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Hepatoprotective * Hypocholesterolemic 2-6 g/man/day/orl Martindale's 30th Hypocholesterolemic 9-3,330 mg/man/day/orl Martindale's 28th Hypoglycemic Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989. Hypolipidemic 2-6 g/day * Pesticide * Spermicide Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990. Ubiquiot Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Ulcerogenic 500 mg/kg ipr rat *
4	CHIMAPHILIN	Plant	--	2000.0	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Allelochemic IC92=4 mM Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. Antibacterial * Pesticide * Urinary-Antiseptic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
12	EPICATECHIN-GALLATE	Plant	--	--	--	Leung, A.Y., Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, John Wiley & Sons, New York, 1980.
Anticariogenic * Antihepatotoxic Okuda, T., Yoshida, T., and Hatano, T. Antioxidant Effects of Tannins and Related Polyphenols. Phenolic Compounds in Food and Their Effects on Health, Ch.7 p.93. Antimutagenic * Antioxidant >10 x tocopherol Osawa, T. Phenolic Antioxidants in Dietary Plants as Antimutagens.Phenolic Compounds in Food and Their Effects on Health, Ch.11 p.142. Antiperoxidant Okuda, T., Yoshida, T., and Hatano, T. Antioxidant Effects of Tannins and Related Polyphenols. Phenolic Compounds in Food and Their Effects on Health, Ch.7 p.93. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. COMP-Inhibitor Dullo, A. G., et al. 1999. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am. J. Clinical Nutrition, 70: 1040-1045. Glucosyl-Transferase-Inhibitor * Immunostimulant McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82. Lipoxygenase-Inhibitor IC50=18 uM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Mitogen * Xanthine-Oxidase-Inhibitor IC50=>40 Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
0	GUM	Plant	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
0	HENTRIACONTANE	Plant	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
0	HOMOGENTISIC-ACID-GLUCOSIDE	Plant	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
30	HYPEROSIDE	Plant	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Aldose-Reductase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Analgesic * Antiaging * Antibacterial MIC=250-500 ug/ml Planta Medica, 57: A43, 1991. Anticancer * Anticapillary-Fragility Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Antidermatitic * Antielastase IC50=0.15 ug/ml * Antiflu Leung, A.Y., Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, John Wiley & Sons, New York, 1980. Antihepatotoxic Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Antiinflammatory 1/4 indomethacin Planta Medica, 57: A131, 1991. Antiischemic * Antinociceptive * Antioxidant IC50=4.6 uM * Antiradicular * Antitussive * Antiviral * Antiwrinkle * Calcium-Antagonist * cAMP-Inhibitor IC50=0.14 mg/ml Schussler, M., Fricke, U., Nikolov, N., and Holzl, J. 1991. Comparison of the Flavonoids Occurring in Crataegus species and Inhibition of 3',5'-Cyclic Adenosine Monophosphate Phosphodiesterase. Plant Medica 57: Suppl Issue 2. p.A-133. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Capillarifortificant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Capillarigenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Cyclooxygenase-Activator 100 uM Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Diuretic * Hepatoprotective IC80=30 ug/ml Mayumi Ito (nee Someya), et al. 1990. Hepatoprotective Compounds from Canarium album and Euphorbia nematocypha. Chem. Pharm. Bull. 38(8): 2201-2203, 1990. Hypotensive ivn dog * Pesticide * Tissue-Thromboplastin-Inhibitor IC50=20.8 uM * Xanthine-Oxidase-Inhibitor *
0	ISOHOMOARBUTIN	Plant	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
75	KAEMPFEROL	Plant	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
11B-HSD-Inhibitor * 5-Lipoxygenase-Inhibitor IC50 (uM)=20 * Aldose-Reductase-Inhibitor 100 uM Oliveira, T. T., Nagem, T. J., Miranda, L. C. G., Paula, V. F., Teixeira, M. A. 1997. Inhibitory Action on Aldose Reductase by Soybean Flavonoids. J Braz Chem Soc, 8(3): 211-213. Antiaflatoxin IC50=8.73 uM * Antiaflatoxin IC50=3.28 ppm * Antiaggregant 30 uM * Antiallergic * Antibacterial 20 ug/ml * Anticancer * Antifertility 250 mg/kg/day/60 days/orl rat Kumar, P., Dixit, V.P., and Khanna, P. Antifertility Studies of Kaempferol: Isolation and Identification from Tissue Culture of some Medicinally Important Plant Species. Plantes medicinales et phytotherapie, 23: 193-201, 1989. Antigingivitic 20 ug/ml Antiherpetic 23-92 ug/ml Amoros, M., Simoes, C.M.O., Girre, L., et al. Synergistic Effect Of Flavones And Flavonols Against Herpes Simplex Virus Type 1 In Cell Culture. Comparison With The Antiviral Activity Of Propolis. J. of Natural Products 55(12):1732-1740, 1992. Antihistaminic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antiimplantation * Antiinflammatory 20 mg/kg * Antiinflammatory 200 mg/kg ipr rat * Antileukemic IC50=3.1 ug/ml Life Sciences 55: 1061. Antilymphocytic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antimutagenic ID50=10-40 nM Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp. Antioxidant 3/4 quercetin * Antioxidant IC50=1.2 ug/ml * Antioxidant IC50=40 uM * Antiperiodontic 20 ug/ml * Antiplaque 20 ug/ml * Antiradicular 7 x quercetin * Antiseptic 20 ug/ml * Antiserotonin 200 mg/kg ipr rat * Antispasmodic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989. Antistaphylococcic * Antitumor * Antitumor-Promoter Yasukawa, K., Takido, M., Takeuchi, M., Sato, Y., Nitta, K., and Nakagawa, S. 1989. Inhibitory Effects of Flavonol Glycosides on 12-O-Tetradecanoylphorbol-13-acetate-Induced Tumor Promotion. Chem. Pharm. Bull. 38(3): 774-776, 1990. Antiulcer 50-200 mg/kg ipr rat * Antiviral 23-92 ug/ml * Apoptotic 60 uM * Aromatase-Inhibitor IC12=1 uM/l Journal of Medicinal Food 2: 235.1999. cAMP-Phosphodiesterase-Inhibitor * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Carcinogenic Hutchings, A, Scott, AH, Lewis, G, and Cunningham, A. 1996. Zulu Medicinal Plants. An inventory. University of Natal Press, Pietermaritzburg. 450 pp. Choleretic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Copper-Chelator * COX-2-Inhibitor * Cyclooxygenase-Inhibitor IC50 (uM) =20 * Cytotoxic * Diaphoretic? Lawrence Review of Natural Products, Dec-90. Diuretic * Estrogenic EC50=0.56 uM * Estrogenic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Fungicide 20 ug/ml Father Nature's Farmacy: The aggregate of all these three-letter citations. Hepatoprotective IC50=5.46 uM * Hepatoprotective IC50=1.30 ppm * HIV-RT-Inhibitor IC50=50-150 ug/ml Garcia, J., Morin,* C., Nyasse, B., Sondengam, B-L., Tchouankeu, J-C., and Tsamo, E. Complete Structural Assignments Of An Ergosterol Derivative From Entandrophragma utile. Journal of Natural Products, 54(1): 136-142, 1991. Hypotensive * ICAM-1-Inhibitor * iNOS-Inhibitor IC50=<15 uM * iNOS-Inhibitor IC50=13.9 uM * Inotropic * Iodothyronine-Deiodinase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. JNK-Inhibitor * Lipoxygenase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. MAO-Inhibitor * Mutagenic * Natriuretic * Neuroprotective * NO-Inhibitor IC50=13.9 uM * PAF-Inhibitor * Pesticide * Protisticide Meckes, M., Calzada, F., Tapia-Contreras, A., Cedillo-Rivera, R. 1999. Antiprotozoal Properties of Helianthemum glomeratum. Phytotherapy Research, 13(2): 102-105. Quinone-Reductase-Inducer 3 uM * Teratologic * TNF-alpha-Inhibitor IC50=3.99 uM * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237. Topoisomerase-II-Inhibitor IC50=8.1 ug/ml Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225. Tyrosinase-Inhibitor ID50=230 uM * Uterotrophic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999. Vasodilator *
21	METHYL-SALICYLATE	Plant	--	--	--	Leung, A.Y., Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, John Wiley & Sons, New York, 1980.
Allergenic Martindale's 28th Analgesic * Anaphrodisiac * Antiinflammatory Planta Medica, 56(6): 660, 1990. Antioxidant * Antipyretic * Antiradicular O'Connell, M.J., Webster, N.R. 1989. Hyperoxia and salicylate metabolism in rats. J. Pharm. Pharmacol. 42: 205-206, 1990. Antirheumatalgic Martindale's 28th Antiseptic * Antitartar * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Carminative * Counterirritant Merck 11th Edition Dentifrice Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry FLavor FEMA 70-8,000 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Fungicide * Herpetifuge * Insectifuge Hardie, J., Isaacs, R., Pickett,* J.A., Wadhams, L.J., and Woodcock, C.M. 1994. Methyl Salicylate and (-)-(1R,5S)-Myrtenal are Plant-Derived Repellents for Black Bean Aphid, Aphis Fabae Scop. (Homoptera: Aphididae). J. of Chemical Ecology, 20(11):2847. Insectiphile * Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Pesticide *
2	NONACOSANE	Plant	--	--	--	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Antimutagenic 250 ug/ml * Antiviral Abid Ali Khan, M.M., Jain, D.C., Bhakuni, R.S., Zaim, M., and Thakur, R.S. 1991. Occurrence of some antiviral sterols in Artemisia annua. Plant Science, 75: 161-165, 1991.
64	OLEANOLIC-ACID	Shoot	--	--	--	*
Abortifacient * Antiallergic * Antiarrhythmic 40 mg/kg * Antiatherosclerotic * Antibacterial MIC=625-1,250 ug/ml * Anticarcinomic Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Anticariogenic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Anticomplement IC40-50 0.01 mM/l gpg Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Anticomplement IC80-90 0.05 mM/l gpg Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. Antiedemic IC36=40 mg/kg ipr rat * Antifertility * Antigingivitic MIC=625-1,250 ug/ml * Antihepatotoxic * AntiHIV IC50=21.8 ug/ml * AntiHIV EC50=1.7 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. Antihyperlipidemic * Antiinflammatory 40 mg/kg ipr Aquino, R., De Feo, V., De Simone, F., Pizza, C., and Cirino, G. Plant Metabolites. New Compounds And Anti-Inflammatory Activity Of Uncaria tomentosa. Journal of Natural Products, 54(2): 453-459, 1991. Antiischemic 40 mg/kg Antileukemic Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antileukotriene IC50=17 uM * Antimalarial IC50=70-89 ug/ml * Antinephritic IC50=19-24 uM * Antioxidant Balanehru, S. and Nagarajan, B. 1992. Intervention of Adriamycin Induced Free Radical Damage. Biochemistry International 28(4): 735-744, 1992. Antioxidant IC46=10 uM * Antiperiodontic MIC=625-1,250 ug/ml * Antiperoxidant IC30=200 ug/ml * AntiPGE2 IC50=24 uM * Antiplaque MIC=625-1,250 ug/ml * Antiplasmodial IC50=70-89 ug/ml * Antisarcomic * Antiseptic MIC=625-1,250 ug/ml * AntiTGF-beta IC50=19-24 uM * Antitumor * Antitumor (Breast) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Colon) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Kidney) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Lung) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antitumor (Pancreas) Chiang, L. C., Chiang, W., Chang, M. Y., Ng, L. T., Lin, C. C. 2003. Antileukemic activity of selected natural products in Taiwan. Am J Chin Med, 31(1):37-46. Antiulcer >carbenoxolone * Antiviral EC50=1.7 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. Antiviral IC50=21.8 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. Aromatase-Inhibitor * Beta-Blocker * Beta-Glucuronidase-Inhibitor ~100 mg/kg * Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Cardioprotective 40 mg/kg * Cardiotonic * COX-2-Inhibitor IC50=295 uM/ * COX-2-Inhibitor Ringbom, T., Seguar, L., Noreen, Y., Perera, P., Bohlin, L. 1998. Ursolic Acid from Plantago major, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis. J. Nat. Prod., 61(10): 1212-1215. Cyclooxygenase-Inhibitor * Diuretic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Elastase-Inhibitor IC50=~15 uM * Hepatoprotective Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 211. Hypolipemic * Hypotensive * Immunomodulator * Leucocytogenic * NF-kB-Inhibitor * Phagocytotic * Piscicide ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes. Prostaglandin-Synthesis-Inhibitor igs mus * Sedative * Uterotonic * Vasopressor *
0	RENIFOLIN	Plant	--	--	--	*

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Chimaphila umbellata (Ericaceae)

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