Alphitonia excelsa | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Medicinal

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Activities: 23

Chemicals w/Activities: 5

All Chemicals: 5

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
13	BETULIN	Bark	--	45.0	-0.40	Jim Duke's personal files.
Anticarcinomic * Antifeedant * Antiflu * AntiHIV 6.1 uM * Antiinflammatory Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas. Planta Medica, 61: 9. Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral 6.1 uM Aphidifuge Lugemwa, F.N., Huang, F-Y., Bentley, M.D., Mendel, M.J., and Alford, A.R. 1990. A Heliothis zea Antifeedant from the Abundant Birchbark Triterpene Betulin. J. Agric. Food Chem. 38(2): 493-494. Cytotoxic 600 ppm * Cytotoxic 8.6 uM * Hypolipemic * Prostaglandin-Synthesis-Inhibitor IC50=119 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626. Topoisomerase-II-Inhibitor IC50=38.6 uM *
13	BETULIN	Wood	--	--	--	Jim Duke's personal files.
Anticarcinomic * Antifeedant * Antiflu * AntiHIV 6.1 uM * Antiinflammatory Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas. Planta Medica, 61: 9. Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral 6.1 uM Aphidifuge Lugemwa, F.N., Huang, F-Y., Bentley, M.D., Mendel, M.J., and Alford, A.R. 1990. A Heliothis zea Antifeedant from the Abundant Birchbark Triterpene Betulin. J. Agric. Food Chem. 38(2): 493-494. Cytotoxic 600 ppm * Cytotoxic 8.6 uM * Hypolipemic * Prostaglandin-Synthesis-Inhibitor IC50=119 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626. Topoisomerase-II-Inhibitor IC50=38.6 uM *
22	BETULINIC-ACID	Leaf	--	8700.0	1.14	Jim Duke's personal files.
Anthelmintic * Antibacterial * Anticancer Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Anticarcinomic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiedemic * AntiHIV EC50=2.0 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. AntiHIV 14.8 uM * AntiHIV IC50=6.5 ug/ml * Antiinflammatory Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas. Planta Medica, 61: 9. Antileukemic Antimalarial IC50=19-26 ug/ml * Antimelanomic New York Times, 3/28/95. Antinociceptive * Antiplasmodial IC50=19-26 ug/ml * Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral 14.8 uM * Apoptotic * Cytotoxic 50-100 ppm Biosyn. Prod. Cancer Chemotherapy (Petit et al) Cytotoxic 16.4 uM * Phospholipase-A2-Inhibitor * Prostaglandin-Synthesis-Inhibitor 200 ug/ml Dunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497. Prostaglandin-Synthesis-Inhibitor IC50=101 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.
22	BETULINIC-ACID	Wood	--	500.0	-0.21	Jim Duke's personal files.
Anthelmintic * Antibacterial * Anticancer Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Anticarcinomic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiedemic * AntiHIV EC50=2.0 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. AntiHIV 14.8 uM * AntiHIV IC50=6.5 ug/ml * Antiinflammatory Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas. Planta Medica, 61: 9. Antileukemic Antimalarial IC50=19-26 ug/ml * Antimelanomic New York Times, 3/28/95. Antinociceptive * Antiplasmodial IC50=19-26 ug/ml * Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral 14.8 uM * Apoptotic * Cytotoxic 50-100 ppm Biosyn. Prod. Cancer Chemotherapy (Petit et al) Cytotoxic 16.4 uM * Phospholipase-A2-Inhibitor * Prostaglandin-Synthesis-Inhibitor 200 ug/ml Dunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497. Prostaglandin-Synthesis-Inhibitor IC50=101 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.
22	BETULINIC-ACID	Bark	--	8400.0	0.44	Jim Duke's personal files.
Anthelmintic * Antibacterial * Anticancer Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Anticarcinomic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiedemic * AntiHIV EC50=2.0 ug/ml Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095. AntiHIV 14.8 uM * AntiHIV IC50=6.5 ug/ml * Antiinflammatory Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas. Planta Medica, 61: 9. Antileukemic Antimalarial IC50=19-26 ug/ml * Antimelanomic New York Times, 3/28/95. Antinociceptive * Antiplasmodial IC50=19-26 ug/ml * Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiviral 14.8 uM * Apoptotic * Cytotoxic 50-100 ppm Biosyn. Prod. Cancer Chemotherapy (Petit et al) Cytotoxic 16.4 uM * Phospholipase-A2-Inhibitor * Prostaglandin-Synthesis-Inhibitor 200 ug/ml Dunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497. Prostaglandin-Synthesis-Inhibitor IC50=101 uM Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.

^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Alphitonia excelsa (Rhamnaceae)

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