Agastache foeniculum | Plant | Dr. Duke's Phytochemical and Ethnobotanical Databases

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Common name(s)

Giant Hyssop

How used

Medicinal

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Activities: 130

Chemicals w/Activities: 22

All Chemicals: 36

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# Activity	Chemical Name	Part Filter by plant part	Low PPM	High PPM	StdDev	^*Reference
0	(Z)-BETA-OCIMENE	Plant	3.0	120.0	1.41	*
2	3-OCTANOL	Plant	3.0	35.0	-0.58	*
FLavor FEMA Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry
0	3-OCTANONE	Plant	--	30.0	-0.40	Mazza, G. and Kiehn, F.A. 1992. Essential Oil of Agastache foeniculum, A Potential Source of Methyl Chavicol. J. Ess. Oil Res., 4: 295-299.
0	4-CADENEN-OL	Plant	--	5.0	--	Mazza, G. and Kiehn, F.A. 1992. Essential Oil of Agastache foeniculum, A Potential Source of Methyl Chavicol. J. Ess. Oil Res., 4: 295-299.
16	ACACETIN	Inflorescence	--	--	--	Jim Duke's personal files.
Aldose-Reductase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Allergenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiaflatoxin IC50=7.25 uM * Antiaflatoxin IC50=2.06 ppm * Antiallergic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antihistaminic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antimalarial IC50=4.2-12.6 ug/ml * Antimutagenic Economic & Medicinal Plant Research, 6: 235. Aromatase-Inhibitor IC12=1 uM/l Journal of Medicinal Food 2: 235.1999. Hepatoprotective IC50=2.06 ppm * Hepatoprotective IC50=7.25 uM * Iodothyronine-Deiodinase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Mutagenic * Plasmodicide IC50=4.2-12.6 ug/ml * Protisticide IC50=4.2-12.6 ug/ml * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
16	ACACETIN	Leaf	--	--	--	Jim Duke's personal files.
Aldose-Reductase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Allergenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antiaflatoxin IC50=7.25 uM * Antiaflatoxin IC50=2.06 ppm * Antiallergic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf). Antihistaminic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antimalarial IC50=4.2-12.6 ug/ml * Antimutagenic Economic & Medicinal Plant Research, 6: 235. Aromatase-Inhibitor IC12=1 uM/l Journal of Medicinal Food 2: 235.1999. Hepatoprotective IC50=2.06 ppm * Hepatoprotective IC50=7.25 uM * Iodothyronine-Deiodinase-Inhibitor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Mutagenic * Plasmodicide IC50=4.2-12.6 ug/ml * Protisticide IC50=4.2-12.6 ug/ml * Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
28	ALPHA-PINENE	Plant	1.0	35.0	-0.46	*
Allelochemic * Allergenic * Antiacne * Antibacterial * Antifeedant * Antiflu Economic & Medicinal Plant Research, 5: 195. Antiinflammatory 500 mg/kg * Antipneumonic * Antiseptic * Antispasmodic * Antistaphylococcic * Antiviral Economic & Medicinal Plant Research, 5: 195. Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp. Coleoptophile * Expectorant Michael Castleman 1991. The Healing Herbs. Rodale Press, Emmaus, PA 436 pp. FLavor FEMA 15-150 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Herbicide IC50=30 uM Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Insecticide 0.82 uM/fly * Insectifuge 50 ppm * Insectiphile J. Stored. Prod. Res., 22:141, 1986. Irritant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. P450-2B1-Inhibitor IC50=0.087 uM * Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Pesticide * Sedative Lawrence Review of Natural Products, Jun-90. Spasmogenic * Tranquilizer Lawrence Review of Natural Products, Jun-90. Transdermal *
7	ANISALDEHYDE	Plant	--	1.0	--	Mazza, G. and Kiehn, F.A. 1992. Essential Oil of Agastache foeniculum, A Potential Source of Methyl Chavicol. J. Ess. Oil Res., 4: 295-299.
Antimutagenic Economic & Medicinal Plant Research, 6: 235. Fungicide * Insecticide Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Pesticide * Tyrosinase-Inhibitor ID50=320 uM * Tyrosinase-Inhibitor ID50=0.32 mM * Tyrosinase-Inhibitor ID50=380-970 uM *
24	BENZALDEHYDE	Plant	1.0	135.0	0.05	Mazza, G. and Kiehn, F.A. 1992. Essential Oil of Agastache foeniculum, A Potential Source of Methyl Chavicol. J. Ess. Oil Res., 4: 295-299.
Allergenic * Anesthetic * Antibacterial * Anticancer * Antimutagenic * Antipeptic * Antiseptic * Antispasmodic * Antitumor * Candidicide * FLavor FEMA 150-800 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Immunostimulant * Insecticide Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Insectifuge 50 ppm J. Stored. Prod. Res., 22:141, 1986. Motor-Depressant Buchbauer et al, e.g.Buchbauer et al,1993.Therapeutic properties of essential oils and fragrances. Chap.12 in Teranishi,R, Buttery,R.G and Sugisawa,H. Eds. Bioactive Volatile Compounds from Plants. ACS Symposium Series 525. Amer. Chem. Soc., Washington DC Narcotic Merck 11th Edition Nematicide MLC=1 mg/ml Shoyakugaku Zasshi, 44: 183. Pesticide * Sedative Buchbauer et al, e.g.Buchbauer et al,1993.Therapeutic properties of essential oils and fragrances. Chap.12 in Teranishi,R, Buttery,R.G and Sugisawa,H. Eds. Bioactive Volatile Compounds from Plants. ACS Symposium Series 525. Amer. Chem. Soc., Washington DC Termiticide LD100=5 mg/g * Tyrosinase-Inhibitor ID50=820 uM * Tyrosinase-Inhibitor ID50=87 ug/ml * Tyrosinase-Inhibitor ID50=0.82 mM * Tyrosinase-Inhibitor ID50=830 uM *
13	BETA-PINENE	Plant	2.0	25.0	-0.41	*
Allergenic * Antiinflammatory * Antiseptic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Antispasmodic * Candidicide * FLavor FEMA 15-600 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Herbicide Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Irritant Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253. Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Pesticide * Spasmogenic Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. Transdermal *
0	BETA-SABININE	Plant	1.0	125.0	--	*
9	CAMPHENE	Plant	1.0	35.0	-0.55	*
Allelopathic Wright,C.W.(Ed)2002.Medicinal&Aromatic Plants-Industrial Profiles.Artemisia.344pp.Maffei,M.(Ed)2002.Vetiveria.The Genus Vetiveria.Taylor&Francis.NY,NY.191pp.Southwell,I.,Lowe,R.(Eds)1999.Tea Tree.The Genus Melaleuca.Harwood Acad.Pub.Amsterdam,Netherlands. Antilithic? Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Antioxidant Jim Duke's personal files. Expectorant Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin. FLavor FEMA 15-175 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Hypocholesterolemic? Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Pesticide * Spasmogenic Fitoterapia No.59-1984.
31	CARYOPHYLLENE	Plant	8.0	100.0	-0.44	*
Aldose-Reductase-Inhibitor * Allergenic * Analgesic Taylor, Leslie. 2005. The Healing Power of Rainforest Herbs. SquareOne Publisher, Garden City Park, NY. 519 pp. Antiacne * Antiasthmatic Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. Antibacterial * Anticariogenic MIC=>1,600 ug/ml Muroi, H. and Kubo, I. 1993. Combination Effects of Antibacterial Compounds in Green Tea Flavor against Streptococcus mutans. J. Agric. Food Chem. 41: 1102-1105. Antidermatitic * Antiedemic Shimizu,M., et al. 1990. Anti-inflammatory Constituents of Topically Applied Crude Drugs. IV.1) Constituents and Anti-inflammatory Effect of Paraguayan Crude Drug 'Alhucema' (Lavandula latifolia Vill.)2). Chem. Pharm. Bull. 38(8): 2283-2284, 1990. Antifeedant 500 ppm Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp. Antiinflammatory IC50=100 uM Shimizu,M., et al. 1990. Anti-inflammatory Constituents of Topically Applied Crude Drugs. IV.1) Constituents and Anti-inflammatory Effect of Paraguayan Crude Drug 'Alhucema' (Lavandula latifolia Vill.)2). Chem. Pharm. Bull. 38(8): 2283-2284, 1990. Antileishmanic * Antionychyotic Taylor, Leslie. 2005. The Healing Power of Rainforest Herbs. SquareOne Publisher, Garden City Park, NY. 519 pp. Antiproliferant * Antispasmodic * Antistaphylococcic * Antistreptococcic * Antitumor Zheng, G-Q., Kenney, P.M., and Lam, L.K.T. Sesquiterpenes From Clove (Eugenia caryophyllata) As Potential Anticarcinogenic Agents. Journal of Natural Products 55(7): 999-1003, 1992. Antiulcer Taylor, Leslie. 2005. The Healing Power of Rainforest Herbs. SquareOne Publisher, Garden City Park, NY. 519 pp. Candidicide * FLavor FEMA 20-200 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Fungicide * Gastroprotective Taylor, Leslie. 2005. The Healing Power of Rainforest Herbs. SquareOne Publisher, Garden City Park, NY. 519 pp. Insectifuge * Irritant Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253. Larvicide * Mosquitocide * Perfumery Merck 11th Edition Pesticide * Sedative * Termitifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.
3	CIS-OCIMENE	Plant	3.0	35.0	-0.39	*
Antibacterial Wright,C.W.(Ed)2002.Medicinal&Aromatic Plants-Industrial Profiles.Artemisia.344pp.Maffei,M.(Ed)2002.Vetiveria.The Genus Vetiveria.Taylor&Francis.NY,NY.191pp.Southwell,I.,Lowe,R.(Eds)1999.Tea Tree.The Genus Melaleuca.Harwood Acad.Pub.Amsterdam,Netherlands. Antistaphylococcic Wright,C.W.(Ed)2002.Medicinal&Aromatic Plants-Industrial Profiles.Artemisia.344pp.Maffei,M.(Ed)2002.Vetiveria.The Genus Vetiveria.Taylor&Francis.NY,NY.191pp.Southwell,I.,Lowe,R.(Eds)1999.Tea Tree.The Genus Melaleuca.Harwood Acad.Pub.Amsterdam,Netherlands. Fungicide Wright,C.W.(Ed)2002.Medicinal&Aromatic Plants-Industrial Profiles.Artemisia.344pp.Maffei,M.(Ed)2002.Vetiveria.The Genus Vetiveria.Taylor&Francis.NY,NY.191pp.Southwell,I.,Lowe,R.(Eds)1999.Tea Tree.The Genus Melaleuca.Harwood Acad.Pub.Amsterdam,Netherlands.
4	COSMOSIIN	Inflorescence	--	--	--	Jim Duke's personal files.
Aldose-Reductase-Inhibitor IC40=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888. Aldose-Reductase-Inhibitor IC99=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888. Antibacterial MIC=500 ug/ml Planta Medica, 57: A43, 1991. Candidicide MIC=500 ug/ml Planta Medica, 57: A43, 1991.
4	COSMOSIIN	Leaf	--	--	--	Jim Duke's personal files.
Aldose-Reductase-Inhibitor IC40=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888. Aldose-Reductase-Inhibitor IC99=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888. Antibacterial MIC=500 ug/ml Planta Medica, 57: A43, 1991. Candidicide MIC=500 ug/ml Planta Medica, 57: A43, 1991.
3	CYNAROSIDE	Inflorescence	--	--	--	Jim Duke's personal files.
Aldose-Reductase-Inhibitor IC50=0.99 uM rat (strong activity) Yoshikawa, M., et al. 1999. Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, From the Flowers of Chrysanthemum inducum L. Chem Pharm Bull, 47(3): 340-345. Calcium-Antagonist IC50=1.2 uM rbt * Hypocholesterolemic *
3	CYNAROSIDE	Leaf	--	--	--	Jim Duke's personal files.
Aldose-Reductase-Inhibitor IC50=0.99 uM rat (strong activity) Yoshikawa, M., et al. 1999. Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, From the Flowers of Chrysanthemum inducum L. Chem Pharm Bull, 47(3): 340-345. Calcium-Antagonist IC50=1.2 uM rbt * Hypocholesterolemic *
19	D-LIMONENE	Plant	--	--	--	Jim Duke's personal files.
Antiacetylcholinesterase IC22=1.2 mM * Anticancer (Breast) 8,000 mg/kg * Anticancer (Gastric) * Antimelanomic IC50=450 uM/l * Antitumor (Breast) 8,000 mg/kg * Antitumor (Gastric) * Antitumor-Promoter * Apoptotic 8,000 mg/kg * Cancer-Preventive * Chemopreventive * Differentiator 8,000 mg/kg * FLavor FEMA 30-2,300 Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Hypocholesterolemic * Insecticide * Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990. Litholytic Martindale's 28th Nephrotoxic * P450-2B1-Inhibitor IC50=0.19 uM * Pesticide *
0	DIMETHYL-HEXANAL	Plant	1.0	60.0	--	Mazza, G. and Kiehn, F.A. 1992. Essential Oil of Agastache foeniculum, A Potential Source of Methyl Chavicol. J. Ess. Oil Res., 4: 295-299.

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^*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

Plant Agastache foeniculum (Lamiaceae)

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