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Activities: 161
All Chemicals: 33
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Chemical Low PPM High PPM StdDev *Reference
2-ACETYL-2-DEMETHYLCOLCHICINE Plant-- -- *
2-DEMETHYLCOLCHICINE Tuber-- -- *
Activities (1)
Antitubulin IC50=3.7 uM
2-DESMETHYLDEACETYLCOLCHICINE Tuber-- -- *
2-HYDROXY-6-METHOXYBENZOIC-ACID Tuber-- -- *
3-ACETYL-3-DEMETHYLCOLCHICINE Plant-- -- *
3-DEMETHYL-BETA-LUMICOLCHICINE Tuber-- -- *
3-DEMETHYL-GAMMA-LUMICOLCHICINE Tuber-- -- *
3-DEMETHYLCOLCHICINE Tuber-- -- *
3-DESMETHYLDEMECOLCINE Tuber-- -- *
3-METHYL-COLCHICINE Tuber-- -- *
6-METHOXY-SALICYLIC-ACID Tuber-- -- *
ALPHA-LUMICOLCHICINE Tuber-- -- *
APIGENIN Tuber-- -- *
Activities (101)
11B-HSD-Inhibitor
AntiADD
AntiHIV IC72=200 ug/ml
AntiHIV IC50=143 ug/ml
Antiaflatoxin IC50=9.52 uM
Antiaflatoxin IC50=2.57 ppm
Antiaggregant
Antiaging
Antiallergic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antiangiogenic 4 uM
Antiarrhythmic
Antibacterial Recio, M. C., Rios, J. L., and Villar, A., A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978-1988, Phytotherapy Research, 3(4), 1989, 117-125.
Anticancer (Lung)
Anticomplementary
Antidermatitic Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp.
Antiestrogenic Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
Antiherpetic 20-54 ug/ml
Antihistaminic IC50=10-35 uM
Antiinflammatory #NAME?
Antiinflammatory IC~65=1,000 uM
Antileukemic 20-50 uM
Antimelanomic 1-50 uM
Antimetastatic 1-50 uM
Antimutagenic ID50=10-40 nMPhenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp.
Antimutagenic ID50=0.55 ug/ml
Antioxidant 1.5 x Vit. E
Antioxidant IC28.5=62.5 ug/ml
Antiperistaltic
Antiproliferant 1-50 uM
Antiproliferant IC50=155 uM
Antispasmodic EC50=1-5 uM
Antistress 10 mg/kg
Antithyroid Jim Duke's personal files.
Antitumor 1-50 uM
Antitumor (Breast) 1-50 uM
Antitumor (Lung)
Antitumor (Skin)
Antiviral 20-54 ug/ml
Anxiolytic 10 mg/kg
Apoptotic 12-60 uM
Aromatase-Inhibitor IC65=1 uM/lJournal of Medicinal Food 2: 235.1999.
Beta-Glucuronidase-Inhibitor IC50=~40 uM
CNS-Depressant
COX-1-Inhibitor IC65=1,000 uM
COX-2-Inhibitor IC>65=1,000 uM
COX-2-Inhibitor <40 uM
COX-2-Inhibitor IC50=<15 uM
Calcium-Antagonist? Biochimica & Biophysica Acta, 1115: 69, 1991.
Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Choleretic
Cyclooxygenase-Inhibitor
Cytochrome-P450-1A1-Inhibitor
Cytotoxic IC88=10 ug/mlPlanta Medica, 57: A113, 1991.
Cytotoxic 1-50 uM
Cytotoxic IC50=9.5 uM
DNA-Protective
Deiodinase-Inhibitor Jim Duke's personal files.
Differentiator MIC=30 uM
Differentiator IC40=40 uM
Diuretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Estrogenic EC50=0.1-25 uM/lJournal of Medicinal Food 2: 227.1999.
Estrogenic 16% genistein
Estrogenic EC50=1 uM
HIF-1alpha-Inhibitor
Hyaluronidase-Inhibitor IC50+=50-250 uM
Hypotensive Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
ICAM-1-Inhibitor
IKK-Inhibitor
Inotropic
Interleukin-6-Inhibitor
MAO-Inhibitor
MAPK-Inhibitor
Musculotropic Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp.
Mutagenic
Myorelaxant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
NADH-Oxidase-Inhibitor
NF-kB-Inhibitor
NO-Synthase-Inhibitor 5-50 uM
Nodulation-Signal Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Ornithine-Decarboxylase-Inhibitor
P21-Inducer 10-70 uM
PKC-Inhibitor IC50=10 uM
PTK-Inhibitor 10-100 uM
Pesticide
Polyamine-Synthesis-Inhibitor
Progestational
Protein-Kinase-C-Inhibitor IC50=10-40 uM
Quinone-Reductase-Inducer 20 uMUda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
Radioprotective
Sedative 30-100 mg/kg
Sunscreen
TNF-alpha-Inhibitor IC50=3.27 uM
Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
Topoisomerase-II-Inhibitor 50 ug/mlAzuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318.
Topoisomerase-II-Inhibitor IC28=18 uM
Topoisomerase-II-Inhibitor IC45=180 uM
Uterotrophic EC50=0.1-25 uM/lJournal of Medicinal Food 2: 227.1999.
VEGF-Inhibitor IC50=2-7 uM
Vasodilator
Xanthine-Oxidase-Inhibitor 0.36 uM
iNOS-Inhibitor IC50=<15 uM
AUTUMNALINE Plant-- -- *
BENZOIC-ACID Tuber-- -- *
Activities (20)
Allergenic Martindale's 28th
Anesthetic
Antibacterial 33-1,250 ppm
Antibacterial MBC=800 ug/ml
Antiotitic Martindale's 28th
Antipyretic
Antisalmonella MIC=800 ug/ml
Antiseptic 800 ug/ml
Antiyeast MFC=1,600 ug/ml
Choleretic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Expectorant
FLavor FEMA 250Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry
Fungicide MFC=1,600 ug/ml
Insectifuge Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.
Pesticide
Phytoalexin Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Tyrosinase-Inhibitor ID50=710 uM
Tyrosinase-Inhibitor ID50=640 uM
Uricosuric
Vulnerary
BETA-LUMICOLCHICINE Tuber-- -- *
CHELIDONIC-ACID Plant-- -- *
Activities (2)
Antiwart Mitchell, J. and Rook, A.J. 1923. Botanical Dermatology: plants and plant products injurious to the skin. Vancouver: Greengrass, 1979. xiii, 787 p.: ill.
Irritant Mitchell, J. and Rook, A.J. 1923. Botanical Dermatology: plants and plant products injurious to the skin. Vancouver: Greengrass, 1979. xiii, 787 p.: ill.
COLCHAMINE Tuber-- -- *
Activities (5)
Antiflu
Antiviral Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.
Neoplastic
Pesticide
Teratogenic
COLCHICENE Tuber-- -- *
COLCHICERINE Tuber-- -- *
COLCHICINE Tuber800.0 12300.0 *
Activities (44)
AntiBehcet's Martindale's 28th
AntiHIV EC50=0.01 uM
AntiPaget's 600 ug/3x/day/manMartindale's 29th
Antiamyloidosic Martindale's 29th
Antiarthritic
Antibacterial
Anticirrhotic 1-2 mg/man/dayMartindale's 28th
Antidermatitic Martindale's 29th
Antierythemic Martindale's 29th
Antiherpetic
Antiinflammatory
Antileukemic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Antimalarial 500 ug/10x/day/manMartindale's 28th
Antimelanomic ED50=0.18 ug/mlJ. Ethnopharmacology, 32: 117.
Antimeningitic 500 ug/2x/man/dayMartindale's 28th
Antimitotic 2 mg/kg scu musBorchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.
Antipericarditis 500-1,000 ug/man/day
Antipodagric 3-6mg man/day/Martindale's 28th
Antipolyserositic 500-600 ug/2-3 x day/man/Martindale's 28th
Antipsoriac Martindale's 28th
Antipyretic
Antirheumatic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Antisarcomic ED50=0.047 ug/mlJ. Ethnopharmacology, 32: 117.
Antithrombocytopenic 600 ug/2-4x/man/dayMartindale's 29th
Antitrypanosomic Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.
Antitubulin IC50=2.4 uM
Antitumor (Breast) ED50=0.022 ug/mlJ. Ethnopharmacology, 32: 117.
Antitumor (Colon) ED50=0.0071 ug/mlJ. Ethnopharmacology, 32: 117.
Antitumor (Lung) ED50=0.043 ug/mlJ. Ethnopharmacology, 32: 117.
Antivasculitic 600 ug/2x/man/dayMartindale's 29th
CNS-Paralytic
CNS-Stimulant
Carcinogenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Cardioactive 15 mg/kg scu rbtBorchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.
Cytotoxic IC50=0.018 uM
Emetic Cooper-Driver, G. A., Chemical substances in plants toxic to animals, pp. 213-47 in Rechcigl, M., Jr., ed. CRC Handbook of Naturally Occurring Food Toxicants, CRC Press, Boca Raton, 1983, 339 pp.
Hepatoprotective
Hypertensive
Irritant Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Pesticide
Purgative
Respiradepressant
Sympathomimetic
Uricosuric
COLCHIFOLINE Plant-- -- *
DEMECOLCEINE Plant-- -- *
DEMECOLCINE Plant-- -- *
Activities (7)
Antileukemic
Antimitotic
Antipodagric
Antitubulin IC50=2.4 uM
Antitumor Merck 11th Edition
MDR-Inhibitor ED50=78 ng/mlTang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
Marrow-Suppresant Martindale's 28th
GAMMA-LUMICOLCHICINE Tuber-- -- *
N-ACETYLDEMECOLCINE Plant-- -- *
N-DEACETYL-N-METHYLCOLCHICINE Tuber-- -- *
N-FORMYL-N-DEACETYLCOLCHICINE Tuber-- -- *
N-METHYLDESACETYLCOLCHICINE Tuber-- -- *
O-ACETYLCOLCHICEINE Plant-- -- *
O-DEMETHYL-N-DEACETYLCOLCHICINE Tuber-- -- *
SALICYLIC-ACID Plant-- -- *
Activities (34)
Aldose-Reductase-Inhibitor 724.6 uMToyomizu, M., Sugiyama, S., Jin, R. L., Nakatsu, T. 1993. Alpha-Glucosidase and Aldose Reductase Inhibitors: Constituents of Cashew, Anacardium occidentale, Nut Shell Liquids. Phytotherapy Research, 7(3): 252-254.
Analgesic
Antiarthritic Madaus, G. 1976. Lehrbuch der Biologischen Hilfmittel. Vol,. 1-3. 2862 pp. (+ 144 p. index). Georg Olms Verlag, Hildescheim. Reprint of 1938 Madaus.
Antibacterial Martindale's 28th
Antidandruff A.L.L. Hunting. Encyclopedia of Shampoo Ingredients. Micelle Press, Cranford NJ. 467 pp.
Antidermatotic
Antieczemic
Antiichthyosic Martindale's 29th
Antiinflammatory Pharmazie, 46: 156, 1991.
Antineuralgic Madaus, G. 1976. Lehrbuch der Biologischen Hilfmittel. Vol,. 1-3. 2862 pp. (+ 144 p. index). Georg Olms Verlag, Hildescheim. Reprint of 1938 Madaus.
Antioncychomycotic Martindale's 29th
Antioxidant Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.
Antiperiodic
Antipodagric
Antipsoriac
Antipyretic
Antirheumatic
Antiseborrheic
Antiseptic A.L.L. Hunting. Encyclopedia of Shampoo Ingredients. Micelle Press, Cranford NJ. 467 pp.
Antitumor
Antitympanitic Merck 11th Edition
COX-2-Inhibitor Newmark, T. M. and Schulick, P. 2000. Herbal Cox-2 Inhibition - Nature's Challenge to Arthritis, Cancer & Alzheimer's Disease. Hohm Press, Prescott AZ.
Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Comedolytic Martindale's 29th
Cyclooxygenase-Inhibitor
Dermatitigenic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Fungicide MIC 1,000 ug/ml
Hypoglycemic Economic & Medicinal Plant Research, 6: 158.
Insectifuge Tunon, H., Thorsell, W., and Bohlin, L. 1993. Mosquito Repelling Activity of Compounds Occurring in Achillea millefolium L. (Asteraceae). Economic Botany 48(2): 111-120, 1994.
Keratolytic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Pesticide
Thermogenic 130 ppm
Tineacide Martindale's 29th
Ulcerogenic
STARCH Tuber-- 210000.0 -1.08 *
Activities (5)
Absorbent Martindale's 29th
Antidote (Iodine) Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antinesidioblastosic Martindale's 29th
Emollient Martindale's 29th
Poultice Martindale's 29th
*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.