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Activities: 103
All Chemicals: 53
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Chemical Low PPM High PPM StdDev *Reference
(-)-BICYCLOSESQUIPHELLANDRENE Essential Oil-- -- *
(-)-CADINA-1(6),4-DIENE Essential Oil-- -- *
(-)-CADINA-3,5-DIENE Essential Oil-- -- *
(-)-TRANS-CALAMENENE Essential Oil-- -- *
(-)-ZONARENE Essential Oil-- -- *
2'-BETA-DIHYDROXY-3'-METHYL-4',6'-DIMETHOXYCHALCONE Shoot-- -- *
2,5-DIHYDROXY-7-METHOXY-6,8-DIMETHYLFLAVAN-3-ONE Leaf-- -- *
3'-O-METHYL-3-4-METHYLENEDIOXY-ELLAGIC ACID Bark-- -- Lowry, J. B. 1968. The Distribution and Potential Taxonomic Value of Alkylated Ellagic Acids. Phytochemistry 7 10: 1803-1813
3,3',4-TRI-O-METHYL-ELLAGIC-ACID Bark-- -- Lowry, J. B. 1968. The Distribution and Potential Taxonomic Value of Alkylated Ellagic Acids. Phytochemistry 7 10: 1803-1813
Activities (3)
Aldose-Reductase-Inhibitor IC50=0.08 uMTerashima, S., Shimizu, M., Nakayama, H., Ishikura, M., et al. 1990. Studies on Aldose Reductase Inhibitors from Medicinal Plant of 'Sinfito,' Potentilla candicans, and Further Synthesis of Their Related Compounds. Chem. Pharm. Bull 38(10):2733-2736, 1990
Antihemorrhagic Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Cytotoxic ED50(KB)=7.7 ug/ml
3,3'-DI-O-METHYL-ELLAGIC-ACID Bark-- -- Lowry, J. B. 1968. The Distribution and Potential Taxonomic Value of Alkylated Ellagic Acids. Phytochemistry 7 10: 1803-1813
3,4,5-TRIMETHOXYBENZOIC-ACID Hl-- -- *
3,4,5-TRIMETHOXYBENZOIC-ACID-METHYL-ESTER Hl-- -- *
3-BETA-30-DIHYDROXYLUP-20(29)-EN-28-OIC-ACID Shoot-- 1.0 *
3-BETA-O-CIS-P-COUMAROYL-MASLINIC-ACID Leaf-- 14.0 *
3-BETA-O-TRANS-P-COUMAROYL-MASLINIC-ACID Leaf-- 30.0 *
3-O-METHYL-ELLAGIC-ACID Bark-- -- Lowry, J. B. 1968. The Distribution and Potential Taxonomic Value of Alkylated Ellagic Acids. Phytochemistry 7 10: 1803-1813
5,7-DIMETHOXY-6-METHYLFLAVANONE Shoot-- -- *
5,7-DIMETHOXYFLAVANONE Shoot-- -- *
5,7-DIMETHOXYFLAVONE Shoot-- -- *
Activities (1)
Antiinflammatory
5-HYDROXY-7-METHOXY-6,8-DIMETHYLFLAVAN-3-ONE Shoot-- -- *
5-HYDROXY-7-METHOXY-6,8-DIMETHYLFLAVANONE Shoot-- -- *
5-HYDROXY-7-METHOXY-6,8-DIMETHYLFLAVONE Shoot-- -- *
5-HYDROXY-7-METHOXY-6-METHYLFLAVANONE Shoot-- -- *
5-HYDROXY-7-METHOXY-6-METHYLFLAVONE Shoot-- -- *
ALLO-AROMADENDRENE Essential Oil-- -- *
ALPHA-COPAENE Essential Oil-- -- *
ALPHA-CUBEBENE Essential Oil-- -- *
ALPHA-GURJUNENE Essential Oil-- -- *
ALPHA-HUMULENE Essential Oil-- -- *
Activities (2)
Antitumor Zheng, G-Q., Kenney, P.M., and Lam, L.K.T. Sesquiterpenes From Clove (Eugenia caryophyllata) As Potential Anticarcinogenic Agents. Journal of Natural Products 55(7): 999-1003, 1992.
Perfumery Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
ALPHA-SELINENE Essential Oil-- -- *
Activities (3)
Antimalarial IC50=>50 ug/mlRukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
Antiplasmodial IC50=>50 ug/mlRukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry
ALPHA-YLANGENE Essential Oil-- -- *
AROMADENDRENE Essential Oil-- -- *
Activities (3)
Antiseptic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Pesticide
BETA-CARYOPHYLLENE Essential Oil-- -- *
BETA-SELINENE Essential Oil-- -- *
Activities (3)
Antimalarial IC50=>50 ug/mlRukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
Antiplasmodial IC50=>50 ug/mlRukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
Perfumery Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry
BETA-SITOSTEROL Shoot-- -- *
Activities (47)
Androgenic
Angiogenic
Anorexic Martindale's 28th
Antiadenomic Merck 11th Edition
Antiandrogenic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990.
Antibacterial Recently became Internat. J. Crude Drug Res. 28(1,2,3,4):1990, page 155.
Anticancer (Breast) Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103.
Anticancer (Cervix)
Anticancer (Lung)
Antiedemic IC54=320 mg/kg orl
Antiestrogenic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990.
Antifeedant Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.
Antifertility Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990.
Antigonadotrophic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990.
Antihyperlipoproteinaemic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antiinflammatory
Antileukemic
Antilymphomic
Antimutagenic 250 ug/ml
Antiophidic 2.3 mg musEconomic & Medicinal Plant Research, 5: 363.
Antioxidant IC44=10 uM
Antiprogestational Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990.
Antiprostaglandin 30 mg/day/12 wks
Antiprostatadenomic Merck 11th Edition
Antiprostatitic 10-20 mg 3 x/day/orl man
Antipyretic Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
Antitumor (Breast) Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103.
Antitumor (Cervix)
Antitumor (Lung)
Antiviral Abid Ali Khan, M.M., Jain, D.C., Bhakuni, R.S., Zaim, M., and Thakur, R.S. 1991. Occurrence of some antiviral sterols in Artemisia annua. Plant Science, 75: 161-165, 1991.
Apoptotic
Artemicide LC50=110 ppmJung, J.H., Pummangura, S., Chaichantipyuth, c., Patarapanich, C., and McLaughlin, J.L. 1989. Bioactive Constituents of Melodorum fruticosum. Phytochemistry. 29(5): 1667-1670. 1990.
Cancer-Preventive Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
Candidicide Recently became Internat. J. Crude Drug Res. 28(1,2,3,4):1990, page 155.
Caspase-8-Inducer
Estrogenic
Febrifuge Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
Gonadotrophic Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990.
Hepatoprotective
Hypocholesterolemic 2-6 g/man/day/orlMartindale's 30th
Hypocholesterolemic 9-3,330 mg/man/day/orlMartindale's 28th
Hypoglycemic Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989.
Hypolipidemic 2-6 g/day
Pesticide
Spermicide Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990.
Ubiquiot Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Ulcerogenic 500 mg/kg ipr rat
BETULINIC-ACID Bark-- 5000.0 -0.02 *
Activities (22)
Anthelmintic
AntiHIV EC50=2.0 ug/mlKashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095.
AntiHIV IC50=6.5 ug/ml
AntiHIV 14.8 uM
Antibacterial
Anticancer Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Anticarcinomic Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antiedemic
Antiinflammatory Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas*. Planta Medica, 61: 9.
Antileukemic
Antimalarial IC50=19-26 ug/ml
Antimelanomic New York Times, 3/28/95.
Antinociceptive
Antiplasmodial IC50=19-26 ug/ml
Antitumor Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
Antiviral 14.8 uM
Apoptotic
Cytotoxic 50-100 ppmBiosyn. Prod. Cancer Chemotherapy (Petit et al)
Cytotoxic 16.4 uM
Phospholipase-A2-Inhibitor
Prostaglandin-Synthesis-Inhibitor 200 ug/mlDunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497.
Prostaglandin-Synthesis-Inhibitor IC50=101 uMHuang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.
BETULINOL Shoot-- -- *
CADINA-1,4-DIENE Essential Oil-- -- *
CHRYSIN-DIMETHYL-ETHER Shoot-- -- *
COLOSOLIC-ACID Shoot-- 3.2 *
DELTA-AMORPHENE Essential Oil-- -- *
DELTA-CADINENE Essential Oil-- -- *
Activities (9)
Aldose-Reductase-Inhibitor
Antiacne
Antibacterial MIC800 ug/mlMuroi, H. and Kubo, I. 1993. Combination Effects of Antibacterial Compounds in Green Tea Flavor against Streptococcus mutans. J. Agric. Food Chem. 41: 1102-1105.
Anticariogenic MIC800 ug/mlMuroi, H. and Kubo, I. 1993. Combination Effects of Antibacterial Compounds in Green Tea Flavor against Streptococcus mutans. J. Agric. Food Chem. 41: 1102-1105.
Antistreptococcic
Cytochrome-P450-Inducer
P450-Inducer
Pesticide
Testosterone-Inducer
DIMETHYLCRYPTOSTROBIN Shoot-- -- *
ELLAGIC-ACID Bark-- -- Lowry, J. B. 1968. The Distribution and Potential Taxonomic Value of Alkylated Ellagic Acids. Phytochemistry 7 10: 1803-1813
Activities (51)
ACE-Inhibitor IC50=5 mM/l
Abortifacient 1.2 mg/kg ivn mus
Aldose-Reductase-Inhibitor IC50=0.2 uM
Aldose-Reductase-Inhibitor IC50=0.2 ug/ml (strong activity)
AntiGTF ID50=20 ug/ml
AntiHIV IC90=200 ug/mlTan, G.T., Pezzuto, J.M., Kinghorn,* A.D., Hughes, S.H. Evaluation Of Natural Products As Inhibitors Of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase. Journal of Natural Products, 54(1): 143-154, 1991.
Antiaflatoxin
Antianaphylactic
Antibacterial 1,250 ug/ml
Antibacterial ID50=20 ug/ml
Anticancer (Cervix) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY.
Anticancer (Colon) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY.
Anticancer (Esophagus) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY.
Anticancer (Mouth) Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY.
Anticariogenic ID50=20 ug/ml
Anticataract Shimizu, M., Horie, S., Terashima, S., Ueno, H., et al. 1989. Studies on Aldose Reductase Inhibitors from Natural Products.II. Active Components of a Paraguayan Crude Drug 'Para-parai mi,' Phyllanthus niruri. Chem. Pharm. Bull. 37(9): 2531-2532, 1989.
Antigingivitic 1,250 ug/ml
Antihyperthyroid
Antiinflammatory
Antimalarial IC50=0.5 uMRukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
Antimutagenic
Antioxidant >50 x tocopherolOsawa, T. Phenolic Antioxidants in Dietary Plants as Antimutagens.Phenolic Compounds in Food and Their Effects on Health, Ch.11 p.142.
Antioxidant IC98=30 ppm
Antioxidant 2/3 quercetin
Antiperiodontic 1,250 ug/ml
Antiperoxidant IC50=29 uMPlanta Medica, 57: A54, 1991.
Antiplaque 1,250 ug/ml
Antiplasmodial IC50=0.5 uMRukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
Antiseptic 1,250 ug/ml
Antistreptococcic ID50=20 ug/ml
Antithyroid Jim Duke's personal files.
Antitumor
Antiviral Economic & Medicinal Plant Research, 5: 224.
Antiyeast IC50=10.5 uM
Apoptotic Joseph, J., Nadeau, D. and Underwood, A. 2001. The Color Code. Hyperion, NY.
Astringent Martindale's 29th
Cancer-Preventive 3 ppm
Candida-SAP-Inhibitor IC50=8.4 uM
Cytotoxic 4.6 ug/mlAdvance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 359.
Deiodinase-Inhibitor Jim Duke's personal files.
Detoxicant
Glucosyl-Transferase-Inhibitor ID50=20 ug/ml
HIV-RT-Inhibitor Economic & Medicinal Plant Research, 5: 224.
Hemostatic Merck 11th Edition
Hepatoprotective IC55=30 ug/mlMayumi Ito (nee Someya), et al. 1990. Hepatoprotective Compounds from Canarium album and Euphorbia nematocypha. Chem. Pharm. Bull. 38(8): 2201-2203, 1990.
Juvabional Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.
Pesticide
Quinone-Reductase-Inducer 0.4 g/kg ratAhn, D., Putt, D., Kresty, L., Stoner, G. D., Fromm, D., Hollenberg, P. F. 1996. The Effects of Dietary Ellagic Acid on Rat Hepatic and Esophageal Mucosal Cytochromes P450 and Phase II Enzymes. Carcinogenesis, 17(4): 821-828.
Sunscreen 0.50%Jim Duke's personal files.
Topoisomerase-I-Antagonist Journal of Medicinal Food 2: 167.1999.
Xanthine-Oxidase-Inhibitor IC50=3.1 uMHatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
FLAVANONE-5,7-DIMETHOXY-6-METHYLFLAVONE Shoot-- -- *
JACOUMARIC-ACID Leaf-- 40.0 *
PINOSTROBIN Shoot-- -- *
Activities (6)
Antiinflammatory
Aromatase-Inhibitor IC52=1 uM/lJournal of Medicinal Food 2: 235.1999.
COX-1-Inhibitor IC36=100 ug/ml
COX-2-Inhibitor IC7=100 ug/ml
Fungicide 2.5 mMGeibel, M. 1994. Sensitivity of the Fungus Cytospora persoonii to the Flavonoids of Prunus cerasus. Phytochemistry. 38(3): 599-601. 1995.
Pesticide
PLATANIC-ACID Shoot-- 0.6 *
STROBOCHRYSIN-DIMETHYL-ETHER Shoot-- -- *
STROBOPININ Shoot-- -- *
STROBOPININ-7-METHYL-ETHER Shoot-- -- *
SYRINGIC-ACID-METHYL-ESTER Hl-- -- *
UVAOL Shoot-- -- *
Activities (6)
Antioxidant IC47=10 uM
Antiproliferative IC50=30->30 uM
Antitumor (Breast) IC50=30->30 uM
Antitumor (Stomach) IC50=30->30 uM
Cytotoxic 100-200 ppm
Lipoxygenase-Inhibitor
*Unless otherwise noted all references are to Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.